Predicort 40 MG Tablet 10

Macmillon Pharmaceuticals

Pack of 10 Units

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MRP ~~₹24.92~~

₹19.94

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Composition

Prednisolone (40 Mg)

Strength:

5 MG 40 MG 10 MG

Predicort 40 MG Tablet 10 is used to manage severe allergic reactions and chronic inflammatory conditions in the body. It belongs to a class of medicines called glucocorticoids, which are synthetic corticosteroid hormones with powerful anti-inflammatory and immunosuppressive effects.

In addition to its primary uses, this medicine can also help with respiratory conditions such as chronic obstructive pulmonary disease (COPD) and asthma, endocrine disorders like congenital adrenal hyperplasia, blood disorders including leukaemia and haemolytic anaemia, and certain neoplastic diseases. It may also be prescribed to prevent organ transplant rejection.

This medicine should be taken orally exactly as directed by your doctor, preferably in the morning with food. Inform your doctor about any pre-existing conditions or ongoing medications before beginning treatment. If you notice any side effects while taking this medicine, notify your doctor immediately. Continue taking the tablet for the duration prescribed by your doctor for optimal results.

Predicort 40 MG Tablet 10 is used for the following:

Severe allergic reactions
Rheumatoid arthritis and other inflammatory joint diseases
Inflammatory bowel conditions like Crohn's disease
Asthma and chronic obstructive pulmonary disease
Skin disorders such as psoriasis
Autoimmune conditions like lupus
Blood disorders, including haemolytic anaemia
Endocrine disorders like adrenal gland problems
Prevention of organ transplant rejection
Certain types of cancers and leukaemia
Kidney inflammation and nephrotic syndrome
Eye inflammation and certain eye disorders

Follow these instructions while taking Predicort 40 MG Tablet 10:

Swallow the tablet whole with a full glass of water.
Do not crush, break, or chew the tablet.
Take your medicine at the same time each day, preferably in the morning.
Never stop taking this medicine suddenly without talking to your doctor.
Consult your doctor for specific advice about your treatment.

Predicort 40 MG Tablet 10 is taken orally.

Predicort 40 MG Tablet 10 may have the following common side effects:

Weight gain
Sleep disturbances
Muscle weakness
Impaired wound healing: The medicine may slow down how quickly your cuts and injuries heal.
Gastritis: This refers to inflammation of the stomach lining which can cause discomfort or pain.
Hyperglycemia: This means high blood sugar levels, which can make you feel thirstier and need to urinate more frequently.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Predicort 40 MG Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Gastritis: Try taking Predicort 40 MG Tablet 10 with food or milk to reduce stomach irritation.
Weight gain: Taking this medicine in the morning rather than evening may help reduce increased appetite throughout the day.

Predicort 40 MG Tablet 10 contains prednisolone (40 mg), which works on the body as follows:

Glucocorticoid Receptor Binding: Prednisolone enters cells and binds to specific receptors called glucocorticoid receptors, which are found throughout your body.
Gene Regulation: After binding to these receptors, prednisolone influences how certain genes are expressed, particularly those involved in producing inflammatory substances.
Anti-inflammatory Action: The medicine reduces inflammation by decreasing the production of substances that cause redness, swelling, and pain in affected tissues.
Immune System Suppression: Prednisolone decreases the activity of your immune system, which helps manage autoimmune conditions where your body mistakenly attacks its own tissues.
Metabolic Effects: The medicine also influences how your body processes fats, proteins, and carbohydrates, which explains some of its effects on energy levels and body composition.

Pregnancy

Predicort 40 MG Tablet 10 should be used during pregnancy only if the potential benefits to you outweigh the risks to your baby. Prednisolone can cross the placenta and may affect your developing baby. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Predicort 40 MG Tablet 10 is not recommended during breastfeeding. Prednisolone passes into breast milk and could affect your nursing baby. If treatment with this medicine is necessary while you are breastfeeding, your doctor may advise you to stop breastfeeding temporarily or monitor your baby for any unusual symptoms.

Alcohol

Caution is advised when consuming alcohol while taking Predicort 40 MG Tablet 10. Both alcohol and prednisolone can irritate your stomach lining, potentially increasing the risk of gastric ulcers and bleeding when combined. It is best to avoid alcohol during your treatment with this medicine.

Liver

Caution is advised while taking Predicort 40 MG Tablet 10 if you have any liver problems. This medicine is processed by your liver and may cause additional stress on this organ. Your doctor may need to adjust your dose if you have liver impairment, so discuss any liver conditions with them before starting treatment.

Kidney

Caution is advised before using Predicort 40 MG Tablet 10 if you have a history of any kidney problems. While the liver primarily processes prednisolone, your kidneys help eliminate it from your body. It is a good idea to consult your doctor before taking this medicine if you have kidney issues.

Using Machines & Driving

Predicort 40 MG Tablet 10 may cause side effects like dizziness, vision changes, or mood alterations in some people. If you experience these effects, avoid driving, operating heavy machinery, or performing activities that require alertness until you know how this medicine affects you.

Allergy

Do not take Predicort 40 MG Tablet 10 if you are allergic to prednisolone or any other ingredients in the tablet. Allergic reactions can be serious and may include rash, itching, swelling of the face/tongue/throat, or breathing difficulties. Tell your doctor about any allergies you have before starting this medicine.

Children

Caution is advised while giving Predicort 40 MG Tablet 10 to children under 18 years of age. Long-term use of prednisolone in children may affect their growth and development. Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Predicort 40 MG Tablet 10 under medical supervision, as they may be more susceptible to its side effects. This includes increased risks of osteoporosis, diabetes, high blood pressure, and infections. Your doctor will monitor you closely and may adjust your dose based on your overall health status.

Drug-Drug Interactions

Predicort 40 MG Tablet 10 interacts with the following medicines:

Anticoagulants: Medicines like warfarin may interact with Predicort 40 MG Tablet 10, potentially increasing your risk of bleeding complications.
Antidiabetic medicines: When taken with Predicort 40 MG Tablet 10, medicines like metformin and insulin may have reduced effectiveness, making it harder to control your blood sugar levels.
NSAIDs: Medicines like aspirin and ibuprofen can increase the risk of stomach bleeding and ulceration when taken with Predicort 40 MG Tablet 10.
Antibiotics: Medicines like rifampin and erythromycin can alter how your body processes prednisolone, affecting how well Predicort 40 MG Tablet 10 works.
Anticonvulsants: Medicines like phenytoin and phenobarbital may increase how quickly your body removes prednisolone, potentially reducing Predicort 40 MG Tablet 10's effectiveness.

Drug-Food Interactions

Predicort 40 MG Tablet 10 interacts with the following foods:

Grapefruit and grapefruit juice: Grapefruit and grapefruit juice should be avoided while taking Predicort 40 MG Tablet 10 because it can inhibit the liver enzyme CYP3A4, which is responsible for breaking down prednisolone.

Drug-Disease Interactions

Predicort 40 MG Tablet 10 interacts with the following diseases:

Systemic fungal infections: Predicort 40 MG Tablet 10 can worsen these infections by suppressing your immune system.
Tuberculosis: Prednisolone may reactivate dormant tuberculosis or worsen active infection.
Diabetes: Predicort 40 MG Tablet 10 can raise blood sugar levels, making diabetes harder to control.
Osteoporosis: Long-term use of Predicort 40 MG Tablet 10 may worsen bone thinning and increase fracture risk.
Psychiatric disorders: Predicort 40 MG Tablet 10 may trigger or worsen depression, mood swings, or psychosis.

Daily Dose

The daily dose of Predicort 40 MG Tablet 10 should be taken as prescribed by your doctor. The dosage may change based on the severity of your condition and how well you respond to treatment. Always follow your doctor's instructions about when and how to take this medicine.

Over Dose

Taking too many Predicort 40 MG Tablet 10 may cause nausea, vomiting, stomach discomfort, and imbalances in your body salts. You might also experience mood changes, sleep problems, and increased blood sugar levels. Contact your doctor if you suspect an overdose.

Missed Dose

If you forget to take Predicort 40 MG Tablet 10, take it as soon as you remember. If it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never take a double dose to make up for a missed one.

Store Predicort 40 MG Tablet 10 at room temperature.
Protect from light and moisture.
Do not refrigerate or freeze the medicine.
Keep out of reach of children and pets.
Discard any unused Predicort 40 MG Tablet 10 after the expiry date on the package.

If you're taking Predicort 40 MG Tablet 10 for inflammatory conditions like arthritis, try to include omega-3 rich foods (such as fatty fish, flaxseeds and walnuts) in your diet, as these have natural anti-inflammatory properties.
Regular, gentle exercise appropriate for your condition can help manage symptoms of chronic inflammatory diseases and may improve your response to prednisolone therapy.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Inflammatory conditions, autoimmune disorders, severe allergies
Drug Category	Glucocorticoid hormone
Therapeutic Category	Anti-inflammatory

Can I stop taking Predicort 40 MG Tablet 10 if I feel better?

No. Never stop taking prednisolone suddenly. Your doctor must reduce your dose gradually to prevent withdrawal symptoms and adrenal insufficiency.

How long does it take for Predicort 40 MG Tablet 10 to work?

You may notice some effects within hours, but full benefits often take several days. For chronic conditions, it might take 1-2 weeks for significant improvement.

Can I drink alcohol while taking this medicine?

It's best to avoid alcohol completely. Combining alcohol with prednisolone increases your risk of stomach irritation, ulcers and bleeding.

Will I gain weight with Predicort 40 MG Tablet 10?

Weight gain is common due to increased appetite and fluid retention. Healthy eating and regular exercise may help minimise this side effect.

What should I do if I miss a dose?

Take it as soon as you remember on the same day. If it's nearly time for your next dose, skip the missed dose. Never take a double dose.

Can I take other medicines alongside Predicort 40 MG Tablet 10?

Always tell your doctor about all medicines you're taking. Prednisolone interacts with many medications, including blood thinners and diabetes medicines.

How should I store this medicine?

Keep it at room temperature in its original container, away from moisture and light. Store out of reach of children.

Last Updated On 10 Jun. 2025 | 9:01AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

17/2, Mall Road, Kennedy Avenue, Amritsar, Punjab 143001

Country of origin: INDIA

Expiry on or after: December 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Shionogi Pharma, Inc. (n.d.). Orapred ODT® (prednisolone sodium phosphate orally disintegrating tablets) highlights of prescribing information. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021959s004lbl.pdf
HIGHLIGHTS OF PRESCRIBING INFORMATION. (2012). [Prescribing information]. In RAYOS (p. 1). https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202020s000lbl.pdf
DailyMed - PREDNISONE tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=10fe5a3b-84dc-4600-87c2-b80c97ce18cf
Prednisolone: uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00860

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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