Lefumib 20 Mg Tablet 10

Johnlee Pharmaceuticals Pvt Ltd

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Composition

Leflunomide (20 Mg)

Lefumib 20 Mg Tablet 10 is used to manage rheumatoid arthritis. It is a single-ingredient disease-modifying antirheumatic medicine containing leflunomide.

This medicine reduces signs and symptoms such as joint pain, stiffness and swelling. It also helps slow structural damage in adults with active rheumatoid arthritis. It also improves physical function and day-to-day mobility. It also helps manage symptoms of active psoriatic arthritis.

Before starting, tell your doctor about your medical conditions and allergies. Tell the doctor about all other medicines, supplements or herbal products you take. Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding. Report persistent or serious side effects to your doctor. Do not stop taking or using the medicine unless your doctor advises you to do so.

Lefumib 20 Mg Tablet 10 is used to manage rheumatoid arthritis.

Uses of Lefumib 20 Mg Tablet 10 are:

Rheumatoid Arthritis: Reduces signs and symptoms such as joint pain, stiffness and swelling.
Slowing Joint Damage: Helps slow structural damage in adults with active rheumatoid arthritis.
Physical Function: Improves physical function and day-to-day mobility.
Psoriatic Arthritis: Helps manage symptoms of active psoriatic arthritis.

Follow these instructions while taking Lefumib 20 Mg Tablet 10:

Swallow the tablet whole with a glass of water.
Avoid crushing, breaking, or chewing the tablet.
Do not alter the dosage or stop taking the medicine without consulting your doctor first.

Lefumib 20 Mg Tablet 10 is taken orally.

Lefumib 20 Mg Tablet 10 may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Lefumib 20 Mg Tablet 10:

Digestive: diarrhoea, nausea, abdominal pain.
Other: oral ulcers.
Skin and application site: hair loss, rash.
Nervous system: headache, dizziness.

If any side effect does not improve or becomes serious, speak to your doctor. Do not stop taking the medicine unless your doctor advises you to do so.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Lefumib 20 Mg Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Try taking Lefumib 20 Mg Tablet 10 with food.
Nausea: Consider taking this medicine after meals to lessen this effect.

Lefumib 20 Mg Tablet 10 contains leflunomide (20 mg). The medicine acts on the body through the following mechanisms:

Inhibition of Pyrimidine Synthesis: Leflunomide blocks the production of pyrimidine, a crucial compound needed for the rapid multiplication of cells. This action targets overactive immune cells responsible for inflammation in arthritis.
Immune System Suppression: By inhibiting pyrimidine synthesis, leflunomide reduces immune system activity, thereby alleviating inflammation, pain, and joint damage while slowing the progression of rheumatoid and psoriatic arthritis.

Pregnancy

Lefumib 20 Mg Tablet 10 is strictly contraindicated during pregnancy as it can cause harm to the developing fetus. If you are pregnant or planning to conceive, discuss this with your doctor before starting the medication.

Breastfeeding

Breastfeeding is not recommended while taking Lefumib 20 Mg Tablet 10, as the medicine may pass into breast milk and harm the nursing infant. Consult your doctor to understand the risks and explore alternative treatment options.

Alcohol

Avoid consuming alcohol while on Lefumib 20 Mg Tablet 10 as it can increase the risk of liver damage. Discuss alcohol use with your doctor, especially if you have a history of liver problems.

Liver

Caution is advised when using Lefumib 20 Mg Tablet 10 in patients with mild to moderate liver impairment. It is contraindicated in cases of severe liver disease. This medicine may affect liver function, so routine liver function tests may be required. If you have any liver conditions, inform your doctor before starting treatment.

Kidney

Patients with a history of kidney problems should use Lefumib 20 Mg Tablet 10 cautiously. Kidney function should be monitored, and your doctor will decide whether this medication is suitable for you.

Use In Driving And Operating Machinery

Lefumib 20 Mg Tablet 10 does not typically impair your ability to drive or operate machinery. However, if you experience side effects like dizziness, fatigue, or weakness, it is best to avoid such activities and consult your doctor.

Allergy

Do not take Lefumib 20 Mg Tablet 10 if you are allergic to leflunomide or any of its ingredients. Always check the composition of the medicine and consult your doctor if you have a history of allergies.

Children

Lefumib 20 Mg Tablet 10 is not recommended for children under 18 years of age. Always consult a pediatrician or healthcare provider before giving this medication to children.

Older Patients

Older patients (above 70 years) should take Lefumib 20 Mg Tablet 10 under strict medical supervision, as they may be more susceptible to side effects such as liver or kidney complications. Your doctor may adjust the dosage and closely monitor your health during treatment.

Drug-Drug Interactions

Lefumib 20 Mg Tablet 10 interacts with the following medicines:

Hepatotoxic medicines: Medicines like methotrexate can interact with Lefumib 20 Mg Tablet 10, potentially increasing the risk of serious liver injury.
Anticoagulants: Medicines like warfarin may interact with Lefumib 20 Mg Tablet 10, potentially increasing the anticoagulant effect.
Immunosuppressants: Combined use with other immune-suppressing medicines such as azathioprine or cyclosporine may increase the risk of infections.

Drug-Disease Interactions

Lefumib 20 Mg Tablet 10 interacts with the following diseases:

Severe Liver Disease: This medication is contraindicated in patients with severe liver impairment as it may worsen liver function.
Severe Infections: Patients with active severe infections should avoid starting Lefumib 20 Mg Tablet 10 until the infection is fully treated, as the medication suppresses the immune system.
Immune Deficiency: Due to its immunosuppressive effects, Lefumib 20 Mg Tablet 10 is not recommended for individuals with severe immune deficiencies.
Bone Marrow Disorders: This medicine can affect blood cell production, including white blood cells, red blood cells, and platelets, and is not suitable for patients with impaired bone marrow function.

Daily Dose

The daily dose of Lefumib 20 Mg Tablet 10 should be taken as directed by your doctor. The prescribed dosage may vary based on individual circumstances such as the severity of your condition and how you respond to the medicine. It's crucial to adhere to your doctor's instructions and not exceed the recommended dose without seeking medical advice.

Over Dose

If you accidentally take more than the recommended dose, you might experience side effects such as nausea, abdominal discomfort, or dizziness. Should these symptoms persist, inform your doctor. Always stick to the prescribed dosage to avoid such instances.

Missed Dose

If you forget to take your Lefumib 20 Mg Tablet 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and carry on with your normal schedule. Never double up your dosage without consulting your doctor.

Always keep Lefumib 20 Mg Tablet 10 in its original packaging.
Store it at room temperature, ideally below 25°C.
Keep it away from direct light and moisture to maintain its efficacy.
Make sure the medicine is kept out of the reach of children.
Remember to check the expiry date on the packet before using the medicine.

If you're taking Lefumib 20 Mg Tablet 10 for rheumatoid or psoriatic arthritis, aim to maintain a balanced diet rich in Omega-3 fatty acids (found in fish, walnuts, flaxseeds) which may help reduce inflammation.
Regular low-impact exercises like swimming or cycling can help keep your joints flexible and strong without causing pressure or pain. Always consult your doctor before starting any new exercise routine.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Rheumatoid Arthritis, Psoriatic Arthritis
Drug Category	Pyrimidine Synthesis Inhibitor
Therapeutic Category	DMARD (Disease-Modifying Antirheumatic Medicines)

What is Lefumib 20 Mg Tablet 10 used for?

Lefumib 20 Mg Tablet 10 is used to manage symptoms and slow down the progression of rheumatoid and psoriatic arthritis in adults.

How does Lefumib 20 Mg Tablet 10 work?

Lefumib 20 Mg Tablet 10 works by inhibiting the production of a substance needed for rapidly dividing cells, thus reducing inflammation and slowing arthritis progression.

Can Lefumib 20 Mg Tablet 10 be taken with food?

You must take the medicine as directed by your doctor.

What are the common side effects of Lefumib 20 Mg Tablet 10?

Side effects can include diarrhoea, nausea, abdominal pain, oral ulcers, hair loss, rash, headache, and dizziness. Consult your doctor if these persist or worsen.

Is Lefumib 20 Mg Tablet 10 safe during pregnancy?

No, Lefumib 20 Mg Tablet 10 may cause birth defects and should not be taken during pregnancy. Women must use reliable contraception during and after treatment.

What precautions should I take while using Lefumib 20 Mg Tablet 10?

Inform your doctor about all your health conditions especially liver disease, immunodeficiency, bone marrow problems, diabetes, and any active or chronic infections before starting this medication.

Can Lefumib 20 Mg Tablet 10 interact with other medicines?

Yes, it may interact with several medications such as hepatotoxic medicines and anticoagulants like warfarin. Always inform your doctor about all medicines you're currently taking.

Last Updated On 09 Sep. 2026 | 1:06PM (IST)

Certified Content

Written by

Dr. Divya Mandial

Medical Content Writer | 10 years

PhD in Chemistry

Reviewed by

Pragati Bhosale

Medical Content Reviewer | 5 years

M. Pharmacy

Check out Editorial Policy

Manufacturer details

42/44, Babu Genu Road, Shop No. 06, 2nd Floor, Om Shanti Co-op Housing Society, Kalbadevi Road, Mumbai-400002. (India)

Country of origin: INDIA

Expiry on or after: January 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

ARAVA. (n.d.). ARAVA Tablets (leflunomide) 10 mg, 20 mg, 100 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
Padda, I. S., & Goyal, A. (2023, June 3). Leflunomide. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557799/
Leflunomide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01097
Leflunomide: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a600032.html

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

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