Darbitop Injection 0.42ml is used in adults for the management of anaemia associated with chronic kidney disease (CKD) and anaemia caused by chemotherapy in certain cancer patients. It belongs to the class of medicines called erythropoiesis-stimulating agents (ESAs).
It helps to reduce the need for blood transfusions in patients with anaemia by stimulating the bone marrow to produce more red blood cells. This medicine is not suitable for immediate correction of severe anaemia and must be used under close medical supervision.
Before starting this injection, it is necessary to consult your doctor. The dosage and frequency will be decided based on your haemoglobin levels, kidney function, and overall health. If you experience any unusual symptoms or suspected side effects during therapy, seek medical advice immediately.
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Darbitop Injection 0.42ml
Pre-filled syringe of 0.42 ML
Old MRP ₹2050
MRP ₹1921.87
₹1537.5
₹4575.88/ML
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Prescription required for this medicine
Store in refrigerator or (2o - 8o C) Do Not Freeze
CompositionAbout Darbitop Injection 0.42ml
Uses of Darbitop Injection 0.42ml
Darbitop Injection 0.42ml is used for:
- Treatment of anaemia associated with chronic kidney disease (CKD), both in patients on dialysis and those not on dialysis.
- Treatment of anaemia in cancer patients receiving chemotherapy to reduce the need for blood transfusions.
Directions for Use of Darbitop Injection 0.42ml
- Darbitop Injection 0.42ml is given as an injection under the skin (subcutaneous) or into a vein (intravenous) as directed by your doctor.
- The injection should be administered by a healthcare professional. Do not attempt self-injection.
Route of Administration
Darbitop Injection 0.42ml is meant for subcutaneous or intravenous injection use only.
Side Effects of Darbitop Injection 0.42ml
Darbitop Injection 0.42ml may cause the following common side effects:
- High blood pressure
- Swelling of hands, feet, or legs
- Headache
- Diarrhoea
- Fatigue
Management Of Side Effects:
Most side effects are temporary and resolve after discontinuing or adjusting the dose of Darbitop Injection 0.42ml. However, seek medical advice if side effects worsen.
- High blood pressure: Monitor blood pressure regularly and follow dietary restrictions on salt intake as advised.
- Swelling: Reduce excess salt intake and elevate your legs while resting.
- Headache: Ensure adequate hydration, take rest, and use mild pain relievers if recommended by your doctor.
How Darbitop Injection 0.42ml Works?
Darbitop Injection 0.42ml contains the following active component:
- Darbepoetin Alfa (25 Mg): Darbepoetin Alfa is a synthetic erythropoiesis-stimulating agent that mimics the action of erythropoietin, a natural hormone. It binds to erythropoietin receptors on bone marrow cells and promotes the maturation and production of red blood cells. This leads to improved oxygen delivery in the body and relief of anaemia-related symptoms.
Safety Measures & Warnings
Pregnancy
Darbitop Injection 0.42ml has limited safety data in pregnancy. It should only be used if the potential benefit outweighs the risks to the unborn baby. Consult your doctor if you are pregnant or planning to conceive.
Breastfeeding
Caution should be exercised when administering Darbitop Injection 0.42ml to breastfeeding women. Breastfeeding women should use this medicine only under medical advice.
Alcohol
Alcohol does not directly interact with Darbitop Injection 0.42ml, but excessive alcohol use can worsen anaemia, impair kidney function, and increase blood pressure. Limiting alcohol intake is recommended.
Liver
Patients with liver disease should use Darbitop Injection 0.42ml cautiously, as the metabolism and clearance of the medicine may be altered. Inform your doctor about any history of liver problems.
Kidney
Darbitop Injection 0.42ml is mainly used in kidney-related anaemia. Patients with advanced kidney disease require regular monitoring of haemoglobin, blood pressure, and iron levels during therapy.
Use In Driving And Operating Machinery
Darbitop Injection 0.42ml may cause dizziness, fatigue, or drowsiness in some patients. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Allergy
Patients with known allergy to Darbepoetin Alfa or any component of the injection should not use Darbitop Injection 0.42ml. Allergic reactions may include rash, itching, swelling, or difficulty in breathing. Immediate medical attention is required.
Children
Darbitop Injection 0.42ml is approved for use in children with chronic kidney disease-associated anaemia and cancer in the children 1 year and above. The dosage must be strictly determined by the treating doctor.
Older Patients
Elderly patients generally tolerate Darbitop Injection 0.42ml well. However, they may be more prone to cardiovascular side effects such as high blood pressure or risk of clots. Close monitoring is advised.
Interactions of Darbitop Injection 0.42ml
Drug-Drug Interactions
Darbitop Injection 0.42ml may interact with the following medicines:
- Anticoagulants (e.g., warfarin, heparin): May alter clotting balance and increase the risk of bleeding.
- Antiplatelet agents (e.g., aspirin, clopidogrel): May increase the risk of bleeding complications when combined.
- Immunosuppressants (e.g., ciclosporin, tacrolimus): May affect kidney function and alter response to treatment.
Drug-Disease Interactions
Darbitop Injection 0.42ml interacts with the following conditions:
- Uncontrolled hypertension: May worsen blood pressure control.
- History of blood clots: May increase risk of thrombosis.
- Seizure disorders: May increase risk of seizures in susceptible patients.
- Cardiovascular disease: May raise risk of heart attack or stroke in some individuals.
Dosage of Darbitop Injection 0.42ml
Daily Dose
The recommended dose of Darbitop Injection 0.42ml is individualised by your doctor based on your haemoglobin levels and treatment response. Regular monitoring is required to adjust the dosage.
Over Dose
Overdose of Darbitop Injection 0.42ml is unlikely as it is administered by a healthcare professional.
Missed Dose
If you miss a scheduled hospital appointment for your injection, contact your doctor or hospital immediately to arrange the next dose. Do not double the dose to make up for the missed one.
Storage
- Store at 2–8°C (refrigerated). Do not freeze.
- Keep the injection in its original packaging to protect from light.
- Keep out of reach and sight of children.
- Do not use after the expiry date printed on the packaging.
Special Dietary And Lifestyle Recommendation
- Balanced diet: Ensure adequate intake of iron, vitamin B12, and folate to support red blood cell production.
- Avoid smoking: Smoking reduces oxygen delivery to tissues and worsens anaemia.
- Monitor blood pressure: Follow a low-salt diet and lifestyle changes recommended by your doctor.
- Regular exercise: Gentle physical activity helps improve energy levels and reduces fatigue.
Fact Box
| Dosage Forms Available | Injection |
| Habit Forming | No |
| Ailment | Anaemia due to chronic kidney disease and chemotherapy |
| Drug Category | Erythropoiesis-stimulating agent |
| Therapeutic Category | Haematology medicine |
Frequently Asked Questions (FAQs)
What is Darbitop Injection 0.42ml used for?
Can Darbitop Injection 0.42ml be used to treat all types of anaemia?
Can I take Darbitop Injection 0.42ml during pregnancy?
Does Darbitop Injection 0.42ml replace the need for blood transfusion completely?
Can children use Darbitop Injection 0.42ml?
Does Darbitop Injection 0.42ml affect driving?
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Manufacturer details
Country of origin: INDIA
References
- Aranesp® (darbepoetin alfa). (N.d.). Fda.Gov. Retrieved September 22, 2025, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103951orig1s5173_103951orig1s5258lbl.pdf
- Darbepoetin alfa. (n.d.). Drugs.Com. Retrieved September 22, 2025, from https://www.drugs.com/mtm/darbepoetin-alfa.html
- Darbepoetin alfa. (n.d.). Retrieved September 22, 2025, from https://go.drugbank.com/drugs/DB00012
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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