Pegihep 100 Injection 1 is used in adults for the treatment of chronic hepatitis C in patients with compensated liver disease who have not been previously treated with interferon alpha. It may be used alone or in combination with ribavirin, as prescribed by the doctor. It belongs to the class of medicines known as immune-modulating agents.
This medicine stimulates the body’s natural defence mechanisms against viruses and abnormal cell growth. By mimicking the actions of natural interferons produced by the immune system, it helps the body fight viral infections and improves long-term liver health.
The dosage and duration of therapy will be determined based on your clinical condition, viral load, liver function, and overall health status. Close monitoring during treatment is necessary, and medical advice should be sought immediately if unusual symptoms or suspected side effects occur.
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Pegihep 100 Injection 1
Zydus Lifesciences Limited
Vial of 1 Units
Old MRP ₹7556.5
MRP ₹7084.22
₹5667.38
₹7084.22/Units
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Safe packing and storage
Non returnable productView policy
Prescription required for this medicine
Store in refrigerator or (2o - 8o C) Do Not Freeze
CompositionAbout Pegihep 100 Injection 1
Uses of Pegihep 100 Injection 1
Pegihep 100 Injection 1 is used for:
- Treatment of chronic hepatitis C infection in adults with compensated liver disease.
- Reducing viral replication and improving liver enzyme levels.
Directions for Use of Pegihep 100 Injection 1
- Pegihep 100 Injection 1 is administered as a subcutaneous injection.
- Ensure hands are clean before preparing the injection.
- The injection should be administered under the skin of the thigh, abdomen, or upper arm as instructed by your healthcare provider.
- Rotate injection sites to avoid irritation.
- Do not inject into inflamed, bruised, or scarred areas of skin.
- Always follow the dosing schedule given by your doctor.
Route of Administration
Pegihep 100 Injection 1 is meant for subcutaneous injection only.
Side Effects of Pegihep 100 Injection 1
Pegihep 100 Injection 1 may cause the following common side effects:
- Bruise, itchiness, irritation at injection site
- Flu-like symptoms (fever, chills, fatigue)
- Muscle pain, joint pain
- Nausea
- Indigestion
- Anorexia
- Hair thinning or hair loss
- Depression or mood changes
- Weight loss
Managing the Side Effects:
Most side effects are temporary and resolve with continued treatment. If they persist or worsen, consult your doctor.
- Hair thinning: Use mild shampoos, avoid harsh hair treatments, and maintain a protein-rich diet.
- Depression or mood changes: Seek medical support and inform your doctor promptly.
- Nausea or indigestion: Eat smaller, frequent meals and avoid heavy or greasy foods.
How Pegihep 100 Injection 1 Works?
Pegihep 100 Injection 1 contains the following active component:
- Pegylated Interferon Alpha 2b (0.1 mg): Pegylated interferon alpha 2b is a synthetic version of interferons naturally produced by the immune system. The pegylation process prolongs its duration of action, allowing for once-weekly dosing. It helps regulate immune response, reduces viral replication, and slows disease progression in chronic hepatitis C.
Safety Measures & Warnings
Pregnancy
Pegihep 100 Injection 1 is not recommended during pregnancy due to risk of harm to the unborn baby. If used in combination with ribavirin, pregnancy is strictly contraindicated. Women of childbearing potential must use effective contraception during treatment.
Breastfeeding
Breastfeeding is not recommended while using Pegihep 100 Injection 1.
Alcohol
Alcohol consumption can worsen liver disease and reduce treatment effectiveness. It is strongly advised to avoid alcohol during therapy.
Liver
Patients with decompensated liver disease should not use Pegihep 100 Injection 1. It is indicated only for those with compensated liver disease. Regular liver function tests are essential during therapy.
Kidney
Caution is advised in patients with kidney impairment. Dose adjustments may be required based on kidney function.
Using Machines & Driving
Pegihep 100 Injection 1 may cause dizziness, fatigue, or confusion. Avoid driving or operating machinery until you know how this medicine affects you.
Allergy
Patients allergic to interferons or any component of Pegihep 100 Injection 1 should not use this medicine. Severe allergic reactions may include rash, swelling, or difficulty breathing. Immediate medical attention is required.
Children
Pegihep 100 Injection 1 is generally not recommended in children and adolescents. Use may be considered only under strict medical guidance.
Older Patients
Elderly patients may be more sensitive to the side effects such as fatigue, depression, or appetite loss. Careful monitoring is necessary.
Interactions of Pegihep 100 Injection 1
Drug-Drug Interactions
#sku_name# may interact with medications such as:
- Xanthines (theophylline, aminophylline): The concomitant use may increase their levels and toxicity.
- Nucleoside reverse transcriptase inhibitors (zidovudine, lamivudine): The concomitant use may increase risk of anaemia or liver toxicity.
- Anticoagulants (warfarin, heparin): The concomitant use may increase risk of bleeding.
- Anticonvulsants (phenytoin, phenobarbital): The concomitant use may alter medication levels and seizure control.
Drug-Disease Interactions
Pegihep 100 Injection 1 may interact with following conditions:
- Autoimmune hepatitis: Use of Pegihep 100 Injection 1 may worsen underlying autoimmune inflammation of the liver, leading to disease progression.
- Decompensated liver disease: Pegihep 100 Injection 1 is contraindicated as it can further impair liver function and precipitate hepatic failure.
- Severe psychiatric disorders (e.g., depression, psychosis): Pegihep 100 Injection 1 may aggravate psychiatric symptoms and increase the risk of suicidal thoughts or behaviours.
- Blood disorders (e.g., anaemia, neutropenia): Pegihep 100 Injection 1 can worsen existing cytopenias, raising the risk of infections or bleeding.
- Thyroid dysfunction: Pegihep 100 Injection 1 may trigger or exacerbate hypo- or hyperthyroidism, requiring close monitoring of thyroid function.
Dosage of Pegihep 100 Injection 1
Daily Dose
The recommended dose of Pegihep 100 Injection 1 is determined by your doctor, depending on body weight, liver function, and treatment plan (alone or in combination with ribavirin).
Over Dose
An overdose is highly unlikely for this medication as it is administered by a healthcare professional.
Missed Dose
If you forget to take a dose of Pegihep 100 Injection 1 as scheduled, consult your doctor for advice.
Storage
- Store at 2°C to 8°C (in a refrigerator).
- Do not freeze.
- Keep out of reach of children.
- Do not use after the expiry date printed on the pack.
Diet & Lifestyle
- Avoid alcohol completely during therapy.
- Eat a balanced diet rich in fruits, vegetables, and lean proteins to support liver health.
- Stay hydrated to help manage flu-like side effects.
- Exercise moderately as tolerated to reduce fatigue and support mental well-being.
- Adopt stress management techniques such as yoga or meditation to improve quality of life.
Fact Box
| Available Dosage Types | Injection |
| Habit Forming | No |
| Ailment | Chronic hepatitis C with compensated liver disease |
| Drug Category | Immune-modulating agent |
| Therapeutic Category | Antiviral treatment for hepatitis C |
Frequently Asked Questions (FAQs)
What is Pegihep 100 Injection 1 used for?
Can Pegihep 100 Injection 1 be used in combination with ribavirin?
Does Pegihep 100 Injection 1 cure hepatitis C?
Can children use Pegihep 100 Injection 1?
Does Pegihep 100 Injection 1 affect driving?
Can I consume alcohol during treatment with Pegihep 100 Injection 1?
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Manufacturer details
Country of origin: INDIA
References
- PEG-Intron (Peginterferon alfa-2b) Package Insert. (n.d.). Fda.Gov. Retrieved September 18, 2025, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2001/pegsche080701lb.htm#ind
- PEG-Intron. (n.d.). Europa.Eu. Retrieved September 18, 2025, from https://ec.europa.eu/health/documents/community-register/2016/20160629135304/anx_135304_en.pdf
- Peginterferon alfa-2b. (n.d.). Retrieved September 18, 2025, from https://go.drugbank.com/drugs/DB00022
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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