Oxigran Plus Tablet 10 is used to prevent and treat migraine attacks, reducing their frequency and intensity. It combines flunarizine (a calcium channel blocker that improves blood flow) and propranolol (a beta-blocker that stabilizes serotonin). This dual action prevents migraines by regulating blood flow and pressure, stabilizing overall vascular health.
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Oxigran Plus Tablet 10
Strip of 10 Units
Old MRP ₹95
MRP ₹89.06
₹71.25
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CompositionAbout Oxigran Plus Tablet 10
Uses of Oxigran Plus Tablet 10
Oxigran Plus Tablet 10 used to treat and prevent migraine attacks by modulating activity in the brain. This combination medicine utilizes Propranolol and Flunarizine to regulate nerve excitability and improve cerebral blood flow. By acting on these pathways, it successfully lowers the frequency and intensity of migraine episodes, helping to alleviate symptoms like throbbing pain, nausea, and sensitivity to light or sound.
Directions for Use of Oxigran Plus Tablet 10
- Swallow the tablet whole with a glass of water.
- Do not crush or chew the tablet.
- It is advised to take this medication regularly, preferably at bedtime, as your doctor prescribes.
- Remember not to stop taking this medicine without consulting your doctor first.
Route of Administration
Oxigran Plus Tablet 10 is taken orally.
Side Effects of Oxigran Plus Tablet 10
Oxigran Plus Tablet 10 may cause side effects like drowsiness, fatigue, weight gain, increased appetite, nausea, constipation, stomach discomfort, or slow heartbeat. If these side effects persist or worsen, consult your doctor.
Managing the Side Effects:
Most side effects are temporary and generally harmless, which resolve upon discontinuing Oxigran Plus Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some guidelines for managing common side effects:
- Nausea or stomach discomfort: To lessen the effect of nausea or stomach discomfort, try taking the tablet with food or after meals.
- Drowsiness: If this medicine causes you to feel tired or drowsy during the day, consider taking it at bedtime.
How Oxigran Plus Tablet 10 Works?
Oxigran Plus Tablet 10 contains two active ingredients that work together to prevent migraine headaches:
- Flunarizine (10 mg): This component helps maintain the flow of blood vessels in your head by blocking calcium channels and binding to a protein called calmodulin. This prevents the dilation of blood vessels, which is often a cause of migraine headaches.
- Propranolol (40 mg): It reduces heart rate, blood pressure, and strain on the heart by blocking beta-adrenergic receptors. By diminishing cardiac output and inhibiting the release of a hormone called renin, propranolol lowers blood pressure, which may contribute to its preventive effect on migraines.
Safety Measures & Warnings
Pregnancy
Caution is advised while taking Oxigran Plus Tablet 10 if you are pregnant. It is best to consult your doctor before taking this medicine.
Breastfeeding
Consult your doctor before using this medicine if you are currently breastfeeding.
Alcohol
While there's no known interaction between Oxigran Plus Tablet 10 and alcohol, it's always a good idea to reduce or avoid alcohol consumption while taking any medicine.
Liver
Oxigran Plus Tablet 10 should be used with caution in cases of mild to moderate liver impairment and is not recommended for severe hepatic diseases. If you have liver issues, consult your doctor before starting this medication.
Kidney
If you have a history of kidney problems, it is advisable to consult your doctor before starting Oxigran Plus Tablet 10.
Using Machines & Driving
Oxigran Plus Tablet 10 may cause drowsiness or dizziness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Allergy
This medicine is contraindicated for patients with known hypersensitivity to flunarizine, propranolol, or any of its components. If you have a history of allergies, discuss this with your doctor before starting Oxigran Plus Tablet 10.
Children
Oxigran Plus Tablet 10 is meant for adult use. It should not be given to children under 18 without medical supervision. Consult your doctor before giving any medicine to your child.
Older Patients
Older patients should take this tablet under medical supervision, as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.
Interactions of Oxigran Plus Tablet 10
Drug-Drug Interactions
Oxigran Plus Tablet 10 interacts with the following medicines:
- CYP2D6 inhibitors: Medicines like quinidine and fluoxetine may raise propranolol levels in your body, making side effects more likely.
- CYP1A2 inhibitors: Medications such as cimetidine and ciprofloxacin can increase propranolol levels in your body.
- Calcium channel blockers: Medicines like verapamil and diltiazem can cause slower heart rate and lower blood pressure when taken with Oxigran Plus Tablet 10.
- Antidiabetic agents: Medications like Oxigran Plus Tablet 10 can hide low blood sugar symptoms caused by antidiabetic medications.
- NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): Medicines like ibuprofen can reduce the blood pressure-lowering effect of propranolol in this medication.
Drug-Food Interactions
There are no known food interactions with Oxigran Plus Tablet 10. However, consult your doctor before making any dietary changes when starting a new medication.
Drug-Disease Interactions
Oxigran Plus Tablet 10 interacts with the following diseases:
- Severe heart conditions: The propranolol in Oxigran Plus Tablet 10 can worsen conditions like severe bradycardia, heart block, or cardiogenic shock.
- Severe liver disease: Propranolol is extensively metabolised in the liver. Hence, its use should be avoided in severe hepatic impairment.
- Parkinson's disease: Usage of Oxigran Plus Tablet 10 is not advised if you have Parkinson's disease or a family history of it.
- Depression: If you have depression or a history of depression, consult your doctor before starting this medicine.
Dosage of Oxigran Plus Tablet 10
Daily Dose
The daily dose of Oxigran Plus Tablet 10 should be as your doctor prescribes. This dosage may vary based on factors such as the severity of your condition and how you respond to the medication. Always adhere to the prescribed dosage and avoid exceeding it without consulting your doctor.
Over Dose
Exceeding the recommended Oxigran Plus Tablet 10 dose might result in common side effects like drowsiness, fatigue, or dizziness becoming more pronounced. If you suspect an overdose, inform your doctor.
Missed Dose
If you forget to take a dose of Oxigran Plus Tablet 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosing schedule. Never increase your dosage without consulting your doctor.
Storage
- Keep your Oxigran Plus Tablet 10 in a tight, light-resistant container.
- Store at room temperature, not exceeding 30°C.
- Protect from moisture and direct sunlight.
- Always store this medicine out of reach of children.
- Ensure you use the medicine before its expiry date.
Diet & Lifestyle
- Regular fluid intake can help manage migraines, as dehydration is often a trigger. Sip water throughout the day to maintain hydration levels.
- While small amounts of caffeine can help some migraine sufferers, excessive consumption might exacerbate symptoms. So, limit your consumption of coffee, tea, and other caffeinated drinks.
Fact Box
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Migraine Prophylaxis |
| Drug Category | Calcium Channel Blocker, Beta-adrenergic Blocker |
| Therapeutic Category | Antimigraine |
Frequently Asked Questions (FAQs)
What is Oxigran Plus Tablet 10 used for?
Oxigran Plus Tablet 10 is primarily used for the prevention of migraine, a type of recurring, throbbing headache often accompanied by nausea and sensitivity to light and sound.
How does Oxigran Plus Tablet 10 work?
This medication contains two active ingredients that work together to prevent migraine headaches by maintaining blood vessel tone and reducing heart strain.
Can I take Oxigran Plus Tablet 10 if I am pregnant or breastfeeding?
Consult your doctor before taking this medicine if you are pregnant or breastfeeding.
What should I do if I miss a dose of Oxigran Plus Tablet 10?
If you miss a dose, take it as soon as you remember. But if it's almost time for the next one, skip the missed dose and continue with your regular schedule.
How should I store Oxigran Plus Tablet 10?
Store Oxigran Plus Tablet 10 at room temperature not exceeding 30°C, in a light-resistant container, away from moisture, and out of reach of children.
Can Oxigran Plus Tablet 10 cause side effects?
Yes, common side effects can include drowsiness, weight gain, stomach discomfort, cold extremities, and sleep disturbances. Consult your doctor if these persist or worsen.
Can I drive or operate machinery after taking Oxigran Plus Tablet 10?
Oxigran Plus Tablet 10 may cause drowsiness or dizziness. Avoid driving or operating machinery until you know how the medication affects you.
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Manufacturer details
B 306 Crystal Plaza, New Link Road, Andheri(W), Mumbai, Maharashtra 400053
Country of origin: INDIA
Country of origin: INDIA
Expiry on or after: April 2026
In case of any issues, contact us:
support@truemeds.in|09240250346
Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071
References
- Great Ormond Street Hospital for Children. (n.d.). Flunarizine to prevent migraine. Retrieved April 1, 2024, from https://www.gosh.nhs.uk/conditions-and-treatments/medicines-information/flunarizine-prevent-mig.raine/
- NHS UK. (n.d.). Propranolol. Retrieved April 1, 2024, from https://www.nhs.uk/medicines/propranolol/
- DrugBank Online. (n.d.). Apo-Flunarizine Capsules. Retrieved April 1, 2024, from https://go.drugbank.com/unearth/q?query=Apo-flunarizine%2520capsules&searcher=drugs
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 941361, Flunarizine. Retrieved June 15, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Flunarizine.
- National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 4946, Propranolol. Retrieved June 15, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Propranolol.
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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.
CIN: U62099MH2019PTC320566
Telephone:09240250346
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