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Glimestar M2 Tablet 10

Mankind Pharma Limited

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Composition

Glimepiride (2 Mg) + Metformin (500 Mg)

Glimestar M2 500 Tablet is a medicine used to help control blood sugar in adults with type 2 diabetes when a single medicine is not enough. Good blood sugar control helps reduce the long-term risk of complications such as kidney, nerve and eye damage.

It combines glimepiride, a sulfonylurea that stimulates the pancreas to release more insulin, with metformin, which improves the body's response to insulin. Take it with food as prescribed. Continue taking it regularly to help maintain steady blood sugar control.

A balanced diet with regular meals at set times, regular physical activity and routine blood sugar monitoring can help support better control alongside this medicine.

Before starting this medicine, tell your doctor about any kidney or liver problems, or other medicines you take. Learn the signs of low blood sugar and how to treat them, and report frequent episodes to your doctor.

Glimestar M2 500 Tablet is used to help control blood sugar in adults with type 2 diabetes when a single medicine is not enough, combining glimepiride and metformin for better blood sugar control.
Uses of Glimestar M2 500 Tablet are:
• Type 2 Diabetes: Helps control blood sugar when a single medicine is not enough.
• Complication Risk: Better control helps reduce the risk of diabetes-related complications.

To use Glimestar M2 Tablet, adhere to these guidelines:

Swallow the tablet whole with water.
Avoid crushing or chewing the tablet.
The tablet should be consumed with food, at the same time each day for optimal results.
Continue taking this medicine even if you feel well and your blood sugar is under control.
Always consult your doctor before altering your dose.

Glimestar M2 Tablet is taken orally.

Glimestar M2 500 Tablet may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Glimestar M2 500 Tablet:

Low Blood Sugar: Hypoglycaemia can cause shakiness and sweating.
Digestive: Feeling sick (nausea), loose motions (diarrhoea), stomach pain and taste changes.
Respiratory: Upper respiratory tract infections.
Neurological: Dizziness and headache.
General: Mild weakness or tiredness.

If side effects do not improve or become serious, speak to your doctor right away.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Glimestar M2 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some ways to manage common side effects:

Nausea: Try taking Glimestar M2 Tablet with or after meals to lessen this effect.
Hypoglycemia: Have regular meals and always carry a fast-acting glucose source with you to prevent low blood sugar levels.

Glimestar M2 Tablet consists of two active ingredients:

Glimepiride (2 mg): As a sulfonylurea, glimepiride stimulates the pancreas to secrete more insulin. This action helps lower blood glucose. In addition, it also increases the sensitivity of peripheral tissues to insulin.
Metformin (500 mg): Classified as a biguanide, metformin reduces glucose production in the liver and decreases intestinal absorption of glucose. Furthermore, it improves insulin sensitivity.

Together, these components work to maintain blood sugar control throughout the day due to their prolonged-release formulation.

Pregnancy

Is it safe to take Glimestar M2 Tablet during pregnancy?

If you are pregnant, caution is advised while taking Glimestar M2 Tablet. It is best to consult your doctor before taking this medicine.

Breastfeeding

Is it safe to take Glimestar M2 Tablet during breastfeeding?

Please consult your doctor before proceeding with this medication if you are nursing.

Alcohol

Is it safe to drink alcohol while taking the Glimestar M2 Tablet?

Avoid excessive consumption of alcohol when taking Glimestar M2 Tablet, as it can increase the risk of low blood sugar (hypoglycaemia) and lactic acidosis.

Liver

Is it advisable to take Glimestar M2 Tablet when experiencing liver problems?

If you have mild to moderate liver disease, be cautious when starting Glimestar M2 Tablet, and begin at a lower dose. This medicine is not recommended if you have severe liver disease; consult your doctor for advice.

Kidney

Is it advisable to take Glimestar M2 Tablet when experiencing kidney problems?

As this medicine may affect kidney function, caution is advised if you have a history of kidney problems. Always consult your doctor before taking this medicine.

Use In Driving And Operating Machinery

Is it safe to operate heavy machinery or drive when taking Glimestar M2 Tablet?

Glimestar M2 Tablet may cause side effects that could affect your ability to drive or operate machinery. If you experience symptoms such as dizziness or vision problems, avoid these activities until you feel well again.

Allergy

Are there any specific conditions that should be considered before taking Glimestar M2 Tablet?

This medicine should not be taken if you have known allergies to either glimepiride or metformin or any other ingredients in Glimestar M2 Tablet.

Children

Is Glimestar M2 Tablet suitable for infants or children?

Glimestar M2 Tablet is not recommended for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Is Glimestar M2 Tablet suitable for older patients?

Older patients should take Glimestar M2 Tablet under medical supervision. They may be more susceptible to its side effects, particularly if they have liver or kidney health concerns or are taking other medications. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Glimestar M2 Tablet interacts with the following medicines:

Antidiabetic agents: Other antidiabetic agents like pioglitazone or acarbose may interact with this medicine, potentially leading to increased hypoglycemic effects.
ACE inhibitors: Medicines like ramipril or quinapril may interact with Glimestar M2 Tablet, potentially enhancing its glucose-lowering effect.
Corticosteroids: Long-term use of corticosteroids such as prednisolone and dexamethasone can decrease the effectiveness of this medicine.
Oral contraceptives: Hormonal contraceptives like ethinyl estradiol or levonorgestrel may reduce the hypoglycemic effect of Glimestar M2 Tablet.

Drug-Food Interactions

Glimestar M2 Tablet has known interactions with certain types of food:

High-fat meals: Consuming high-fat meals while taking this medicine may delay the absorption of glimepiride.

Drug-Disease Interactions

Glimestar M2 Tablet interacts with the following diseases:

Liver disease: Patients with mild to moderate liver disease should take this medication cautiously, starting at a lower dose. It's not recommended for those with severe liver disease.
Kidney disease: This medicine is not recommended for individuals with severe kidney disease as it might increase the risk of lactic acidosis.
Heart disease: Patients with heart disease should consult their doctor before starting this medication due to the potential risk of lactic acidosis.
Hypoxia: Conditions that may cause tissue hypoxia, such as acute congestive heart failure, could interact with Glimestar M2 Tablet leading to an increased risk of lactic acidosis.

Daily Dose

The daily dose of Glimestar M2 Tablet should be taken as instructed by your doctor. The dose can vary depending on your individual condition and how your body responds to the medicine. Always follow your doctor's instructions and never change your dosage without consulting them first.

Over Dose

In the event of an overdose, you may experience symptoms such as low blood sugar or lactic acidosis. It's essential that you do not exceed the prescribed dosage of Glimestar M2 Tablet. If you think you have accidentally taken more than your prescribed dose, inform your doctor.

Missed Dose

If you miss a dose of Glimestar M2 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your usual schedule. Never double up on doses to make up for a missed one. Always consult your doctor if you're unsure about what to do after missing a dose.

Store the Glimestar M2 Tablet in a dry place at temperatures not exceeding 30°C.
Protect the medicine from light to maintain its effectiveness.
Keep the tablet out of reach of children for safety reasons.
Make sure to use this medication before its expiration date to ensure its efficacy.

Regular physical activity: Incorporating regular exercise into your routine can aid in managing blood sugar levels. This complements the effects of Glimestar M2 Tablet in controlling type 2 diabetes.
Balanced diet: Consuming a balanced diet with low sugar and high fibre content assists in maintaining stable blood glucose levels, which is crucial when you're taking Glimestar M2 Tablet.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Antidiabetic

What is the Glimestar M2 Tablet used for?

Glimestar-M 2 Tablet is used to control blood sugar in individuals with type 2 diabetes. The combination of Glimepiride and Metformin helps improve insulin sensitivity and decrease glucose production in the liver, effectively managing blood sugar levels.

How does the Glimestar M2 Tablet work?

It contains glimepiride, which stimulates insulin release, and metformin, which reduces glucose production, thereby helping control blood sugar levels.

When should I take Glimestar M2 Tablet?

You should take this medicine daily with food. However, always consult your doctor before starting any medication.

What are the possible side effects of Glimestar M2 Tablet?

Common side effects include hypoglycaemia (low blood glucose), taste changes, nausea, diarrhoea, stomach pain, headaches, and upper respiratory tract infections.

What precautions should I take when using Glimestar M2 Tablet?

Use it with caution if you have mild to moderate liver disease. Inform your doctor about all current medications to avoid potential interactions.

Can I use Glimestar M2 Tablet during pregnancy or while breastfeeding?

It might not be safe to take this medicine during pregnancy and breastfeeding. Please consult your doctor before using.

What should I do if I miss a dose or overdose on Glimestar M2 Tablet?

If you miss a dose, take it as soon as you remember, unless it's close to the next dose. In the event of overdose, seek immediate medical attention.

When is the best time to take Glimestar M2 Tablet?

The best time to take Glimestar M2 Tablet will be decided by your doctor. Taking it with food helps reduce the risk of stomach upset and ensures better absorption of the medication. It should be taken consistently at the same time each day as prescribed by a doctor to maintain stable blood sugar levels.

Last Updated On 30 Sep. 2026 | 7:14AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 10 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 10 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

208, Okhla Industrial Estate-3, New Delhi - 110020

Country of origin: INDIA

Expiry on or after: February 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
Unknown. (n.d.). Metformin hydrochloride Prolonged Release & Glimepiride tablets I.P. [Pharmaceutical Information]. https://www.sanofi.in/dam/jcr:6c1f15ea-d4af-4e93-b38c-91a76293b247/Amaryl%20M%20-%20PI.pdf
Sahay, R. K., Mittal, V., Gopal, G. R., Kota, S., Goyal, G., Abhyankar, M., & Revenkar, S. (2020). Glimepiride and metformin combinations in diabetes comorbidities and complications: Real-World evidence. Curēus. https://doi.org/10.7759/cureus.10700
AMARYL. (n.d.). AMARYL (glimepiride tablets) 1, 2, and 4 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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