Epotrust 4000 Injection 1ml is a medicine used to treat severe anaemia associated with chronic kidney disease, chemotherapy, or HIV therapy. It works by mimicking a natural hormone that signals the bone marrow to produce more red blood cells.
It contains epoetin, an erythropoiesis-stimulating agent. This injection is administered under medical supervision as part of your treatment plan. Regular blood monitoring is essential to maintain safe haemoglobin levels and adjust the dose if needed.
Maintaining good nutrition with adequate iron, vitamin B12, and folate helps support red blood cell production. Following your doctor's advice about dialysis, if needed, and attending all scheduled appointments are important.
Before using this medicine, tell your doctor about any blood clots, uncontrolled high blood pressure, or other conditions. This medicine must be given only by a healthcare professional. Serious blood clots can occasionally occur, so report any signs of chest pain, leg swelling, or difficulty breathing immediately.
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Epotrust 4000 Injection 1Ml
Pre-filled syringe of 1 ML
Old MRP ₹1400
MRP ₹1312.5
₹1050
₹1312.5/ML
100% genuine medicines
Safe & secure payments
Safe packing and storage
Non returnable productView policy
Prescription required for this medicine
Store in refrigerator or (2° - 8° C) Do Not Freeze
CompositionAbout Epotrust 4000 Injection 1Ml
Uses of Epotrust 4000 Injection 1Ml
Epotrust 4000 Injection 1ml is used to treat severe anaemia caused by chronic kidney disease, chemotherapy, or HIV therapy by stimulating red blood cell production.
Uses of Epotrust 4000 Injection 1ml are:
- Chronic Kidney Disease Anaemia: Treats anaemia in people with kidney disease by boosting red blood cell production.
- Chemotherapy-related Anaemia: Manages anaemia caused by cancer treatments.
- Blood Transfusion Reduction: Helps reduce the need for blood transfusions in anaemic patients.
Directions for Use of Epotrust 4000 Injection 1Ml
Follow these instructions when Epotrust 4000 Injection 1ml is administered:
This medicine must be administered by a trained medical professional.
The solution should be inspected before use for any particles or discolouration.
Do not shake the injection vigorously.
The medicine should be at room temperature before administration.
Route of Administration
Epotrust 4000 Injection 1ml is administered intravenously or subcutaneously.
Side Effects of Epotrust 4000 Injection 1Ml
Epotrust 4000 Injection 1ml may cause some side effects during or after treatment; these are usually mild and managed by your care team.
A few common side effects of Epotrust 4000 Injection 1ml:
- Cardiovascular: High blood pressure and increased risk of blood clots.
- Neurological: Headache.
- Musculoskeletal: Joint pain and muscle pain.
- General: Feeling sick (nausea), vomiting, and fever or flu-like symptoms.
If side effects do not improve or become serious, speak to the healthcare team right away.
Management Of Side Effects:
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Epotrust 4000 Injection 1ml. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some general guidelines for managing common side effects:
Nausea: Receiving this medicine after meals may help reduce feelings of sickness.
Flu-like symptoms: Administering this injection in the evening may help you sleep through some of these symptoms.
How Epotrust 4000 Injection 1Ml Works?
Epotrust 4000 Injection 1ml contains erythropoietin (4000 IU), which works in your body through several mechanisms:
Stimulates erythropoiesis: Erythropoietin mimics your body's natural hormone that triggers the production of red blood cells in the bone marrow, a process called erythropoiesis.
Binds to receptors: It attaches to specific receptors on red blood cell precursors in your bone marrow, activating them to develop into mature cells.
Promotes cell differentiation: Erythropoietin encourages immature blood cells to develop and mature into functional red blood cells that can carry oxygen throughout your body.
Increases haemoglobin levels: By boosting red blood cell production, this medicine helps raise haemoglobin levels in your blood, improving oxygen delivery to tissues and organs.
Reduces transfusion needs: Through its action on blood cell production, it decreases the need for blood transfusions in patients with certain types of anaemia.
Safety Measures & Warnings
Pregnancy
Caution is advised while receiving Epotrust 4000 Injection 1ml if you are pregnant. It is best to consult your doctor before starting treatment with this medicine.
Breastfeeding
Caution is advised while receiving Epotrust 4000 Injection 1ml if you are breastfeeding. It is best to consult your doctor before starting treatment with this medicine.
Alcohol
Avoid consuming alcohol while under treatment with Epotrust 4000 Injection 1ml. Alcohol might interfere with your response to this medicine or increase the risk of side effects.
Liver
Caution is advised before receiving treatment with Epotrust 4000 Injection 1ml if you have any liver problems. Your doctor may need to monitor your liver function during treatment, especially if you have pre-existing liver conditions.
Kidney
Epotrust 4000 Injection 1ml is often used to manage anaemia in people with kidney problems. Your doctor will adjust your dose based on your kidney function and monitor your response regularly.
Use In Driving And Operating Machinery
You may feel dizzy or tired after receiving Epotrust 4000 Injection 1ml. If you experience these effects, avoid driving or operating heavy machinery until you feel better.
Allergy
If you have any known allergies to erythropoietin or any component of this medicine, inform your doctor before starting treatment.
Children
Caution is advised while administering Epotrust 4000 Injection 1ml to children. Always consult your doctor before giving any medicine to a child.
Older Patients
Older patients should receive Epotrust 4000 Injection 1ml under close medical supervision. Your doctor will monitor you carefully and adjust the dose as needed based on your overall health status.
Interactions of Epotrust 4000 Injection 1Ml
Drug-Drug Interactions
Epotrust 4000 Injection 1ml interacts with the following medicines:
Antihypertensive medicines: Medicines like enalapril, lisinopril, or amlodipine may require dosage adjustments, as Epotrust 4000 Injection 1ml can worsen existing high blood pressure.
Blood-thinning medicines: Warfarin, heparin, or clopidogrel require careful monitoring when used with Epotrust 4000 Injection 1ml, as there may be an increased risk of blood clots.
Drug-Disease Interactions
Epotrust 4000 Injection 1ml interacts with the following diseases:
Uncontrolled hypertension: This medicine can worsen high blood pressure and should not be used until blood pressure is properly controlled.
Pure red cell aplasia: Patients who developed this rare condition after previous erythropoietin therapy should not use this medicine.
Heart disease: Epotrust 4000 Injection 1ml requires careful monitoring in patients with heart problems due to the increased risk of cardiovascular complications.
Seizure disorders: This medicine may lower the seizure threshold in patients with a history of epilepsy or seizures.
Dosage of Epotrust 4000 Injection 1Ml
Daily Dose
The daily dose of Epotrust 4000 Injection 1ml should be administered as prescribed by your doctor. The dosage may change based on your condition, weight, and response to treatment.
Over Dose
An overdose of Epotrust 4000 Injection 1ml is unlikely as a healthcare professional administers it. However, in case of accidental overdose, erythropoietin may cause high blood pressure, headaches, joint pain, and flu-like symptoms. You might experience dizziness, confusion, and skin rashes. If you notice these symptoms, contact your doctor for advice.
Missed Dose
If you forget your scheduled dose, contact your doctor to receive it as soon as you remember. As this medicine is only administered in a medical setting, any dose adjustments will be decided by your doctor, so please contact them promptly.
Storage
Store Epotrust 4000 Injection 1ml in a refrigerator between 2 and 8°C.
Do not freeze or shake the solution vigorously.
Protect from light exposure.
Keep out of children's reach.
Do not use beyond the expiry date printed on the package.
Special Dietary And Lifestyle Recommendation
Maintain adequate iron intake through iron-rich foods (like leafy greens, beans, and red meat), as this helps your body respond better to erythropoietin treatment and supports red blood cell production.
Stay well-hydrated and follow a balanced diet with sufficient protein to support your kidney function and help manage anaemia associated with chronic kidney disease.
Fact Box
| Dosage Forms Available | Injection |
| Habit Forming | No |
| Ailment | Chronic kidney disease anaemia, chemotherapy-induced anaemia, HIV-related anaemia |
| Drug Category | Erythropoiesis-stimulating agent |
| Therapeutic Category | Anti-anaemia medicine |
Frequently Asked Questions (FAQs)
How does Epotrust 4000 Injection 1ml work in the body?
It mimics your body's natural erythropoietin hormone, stimulating bone marrow to produce more red blood cells to help manage anaemia.
What conditions is this medicine commonly used for?
This medicine helps manage anaemia related to chronic kidney disease, chemotherapy, and HIV treatment with zidovudine and can reduce the need for blood transfusions before surgery.
How is Epotrust 4000 Injection 1ml administered?
A trained medical professional administers it either under your skin (subcutaneous) or into a vein (intravenous), depending on your specific condition.
Why might I need iron supplements with this medicine?
Iron is essential for making red blood cells. Without enough iron, your body cannot respond properly to erythropoietin, reducing the medicine's effectiveness.
What are the common side effects I should know about?
Common side effects include high blood pressure, headache, joint pain, nausea, fever and flu-like symptoms, especially when starting treatment.
How often will my blood need testing during treatment?
Your doctor will regularly monitor your haemoglobin levels, iron status, and blood pressure to ensure the medicine is working properly and safely.
Can I receive this medicine if I have high blood pressure?
Your high blood pressure must be controlled before starting this medicine, as erythropoietin can worsen existing hypertension and require careful monitoring.
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Manufacturer details
Country of origin: INDIA
References
Lundby, C., Thomsen, J. J., Boushel, R., Koskolou, M., Warberg, J., Calbet, J. a. L., & Robach, P. (2006). Erythropoietin treatment elevates haemoglobin concentration by increasing red cell volume and depressing plasma volume. The Journal of Physiology, 578(1), 309–314. https://doi.org/10.1113/jphysiol.2006.122689
MedLinePlus. (n.d.). Epoetin Alfa, Injection. https://medlineplus.gov/druginfo/meds/a692034.html
DrugBank. (n.d.). Erythropoietin. https://go.drugbank.com/drugs/DB00016
Schoener, B., & Borger, J. (2024, July 14). Erythropoietin stimulating agents. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK536997/
Bunn, H. F. (2013). Erythropoietin. Cold Spring Harbor Perspectives in Medicine, 3(3), a011619. https://doi.org/10.1101/cshperspect.a011619
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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