Adival 500 MG Tablet Er 10

Lotus Lifesciences Private Limited

Pack of 10 Units

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MRP ~~₹118~~

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Composition

Divalproex (500 Mg)

Strength:

500 MG 250 MG

Adival 500 MG Tablet Er 10 is used to manage epilepsy, bipolar disorder, and to prevent migraine headaches. It contains divalproex (500 mg), which increases levels of gamma-aminobutyric acid (GABA) in the brain, helping to control seizures and stabilise mood. This medicine is an anticonvulsant and mood-stabilising medication.

The tablet is also used for managing bipolar disorder by stabilising mood swings. It helps alleviate symptoms such as agitation and impulsivity. Additionally, it aids in preventing migraine headaches, reducing their frequency and intensity.

It's crucial to take this medication as directed by your doctor. Before starting this medicine, do let your doctor know about any existing health conditions or other ongoing medicines you're taking. Should any side effects arise while on this medication, inform your doctor immediately. Remember to continue taking this medicine for the entire duration prescribed by your doctor for optimal results.

Adival 500 MG Tablet Er 10 is used for these health conditions:

Management of various types of seizures, including complex partial seizures and simple and complex absence seizures
Stabilising mood swings and reducing symptoms during manic episodes associated with bipolar disorder
Prevention of migraine headaches, reducing their frequency and intensity

Directions for Use of Adival 500 MG Tablet Er 10

Swallow the tablet whole with a glass of water.
Do not crush, chew, or break the tablet.
This medicine can be taken with or without food as prescribed by the doctor.
Always follow your doctor's instructions about when and how to take this medicine.

Adival 500 MG Tablet Er 10 is taken orally.

Side Effects of Adival 500 MG Tablet Er 10

Adival 500 MG Tablet Er 10 may cause the following common side effects:

Diarrhoea
Constipation
Dizziness
Drowsiness
Hair loss
Weight gain
Tremors: This refers to uncontrollable shaking of a part of your body.
Blurred vision: This could lead to difficulty in seeing clearly.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Adival 500 MG Tablet Er 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: You can try taking Adival 500 MG Tablet Er 10 with food to help manage these side effects.
Dizziness: If you feel light-headed or sleepy after taking this medication, it might be helpful to take it at bedtime.

Adival 500 MG Tablet Er 10 contains divalproex (500 mg) and works in the body through the following mechanisms:

Increases GABA levels: Divalproex increases levels of gamma-aminobutyric acid (GABA) in your brain. GABA is a neurotransmitter that helps regulate brain activity.
Controls seizures: By enhancing GABA activity, divalproex effectively controls seizures by inhibiting excessive neuron firing.
Stabilises mood: The enhancement of GABA activity also helps in mood stabilisation, thereby managing symptoms associated with bipolar disorder.
Prevents migraines: Through its effect on GABA activity, divalproex reduces the frequency and intensity of migraine headaches.

Pregnancy

Adival 500 MG Tablet Er 10 is not advisable during pregnancy. If you're pregnant or planning to conceive, consult your doctor before taking this medicine.

Breastfeeding

Breastfeeding mothers should refrain from using Adival 500 MG Tablet Er 10. It's always wise to discuss with your doctor the potential risks and benefits.

Alcohol

While on this medicine, it's best to limit or avoid alcohol as it may intensify side effects such as dizziness and drowsiness.

Liver

As Adival 500 MG Tablet Er 10 can affect liver function, caution is advised if you have mild-to-moderate liver impairment. The medicine isn't recommended for severe liver diseases. Discuss your liver health with your doctor before starting this medicine.

Kidney

If you have a history of kidney problems, use Adival 500 MG Tablet Er 10 with caution. Consult your doctor before taking this medicine.

Using Machines & Driving

Adival 500 MG Tablet Er 10 can cause dizziness and drowsiness, affecting your ability to operate machinery or drive. Do not engage in such activities until you know how the medicine affects you.

Allergy

Do not take Adival 500 MG Tablet Er 10 if you are allergic to divalproex or any of its inactive ingredients. Always check with your doctor if you've had previous allergic reactions to similar medicines.

Children

Adival 500 MG Tablet Er 10 should be given to children below 18 years of age only under medical supervision. Always consult your doctor first.

Older Patients

Older patients may be more susceptible to side effects of Adival 500 MG Tablet Er 10 and might also have liver and kidney concerns. They should use this medicine under medical supervision. Your doctor will guide you based on your health status.

Interactions of Adival 500 MG Tablet Er 10

Drug-Drug Interactions

Adival 500 MG Tablet Er 10 interacts with the following medicines:

Salicylates: Aspirin and other salicylates may interfere with Adival 500 MG Tablet Er 10, altering its effectiveness.
Carbapenem antibiotics: Medications like meropenem and ertapenem can reduce the efficacy of Adival 500 MG Tablet Er 10.
Anticonvulsants: Anticonvulsant medications such as phenytoin and phenobarbital could increase the risk of side effects when taken with Adival 500 MG Tablet Er 10.
Blood thinners: Blood-thinning medicines like warfarin can lead to increased bleeding risk when used alongside this medication.
Benzodiazepines: When used with benzodiazepines such as diazepam or lorazepam, Adival 500 MG Tablet Er 10 may enhance their sedative effects.
Antidepressants: Antidepressant medicines like fluoxetine and sertraline could interact negatively with this medicine.

Drug-Food Interactions

No known specific food interactions with Adival 500 MG Tablet Er 10 have been reported.

Drug-Disease Interactions

Adival 500 MG Tablet Er 10 interacts with the following diseases:

Liver disease: This medicine should be taken with caution by individuals suffering from liver disease, as it could exacerbate their condition.
Pancreatic disorders: Individuals with pancreatic disorders should use this medicine cautiously, as it may worsen their symptoms.
Urea cycle disorders: Patients with urea cycle disorders might experience increased symptoms when taking this medicine.

Daily Dose

The daily dose of Adival 500 MG Tablet Er 10 should be taken exactly as prescribed by your doctor. The dosage may vary depending on personal factors, such as the severity of your condition and your response to the medicine. It’s crucial that you follow this prescribed dosage and don't exceed it without consulting your doctor.

Over Dose

If you happen to take an excess amount of Adival 500 MG Tablet Er 10, you might experience common symptoms like nausea, dizziness, or drowsiness. If these symptoms persist or become severe, inform your doctor right away.

Missed Dose

If you've missed a dose of Adival 500 MG Tablet Er 10, take it as soon as you recall. But if it's nearly time for the next dose, skip the missed one and continue with your regular dosage schedule. Please don't increase your dosage without consulting your doctor.

Store Adival 500 MG Tablet Er 10 at a temperature below 30°C.
Keep the medicine away from light and moisture to maintain its effectiveness.
Ensure the medicine is kept out of reach of children and pets for safety.
Always check the expiry date before use.

As Adival 500 MG Tablet Er 10 is used to manage epilepsy, try to maintain a balanced diet. Certain foods may affect your seizures, so consult your doctor about any dietary restrictions.
If you're managing bipolar disorder with this medicine, regular exercise can help boost your mood. Activities like walking or yoga can make a big difference, but consult your doctor before starting any new fitness regimen.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Epilepsy, Bipolar Disorder, Migraine Prevention
Drug Category	Mood Stabiliser
Therapeutic Category	Anticonvulsant

Can I take Adival 500 MG Tablet Er 10 without food?

You can take Adival 500 MG Tablet Er 10 with or without food. Always follow your doctor's instructions on how to take this medicine.

What if I miss a dose of Adival 500 MG Tablet Er 10?

If you miss a dose, try to take it as soon as you remember. However, if it's close to your next dose, skip the missed dose and continue your regular schedule.

Can I drink alcohol while using Adival 500 MG Tablet Er 10?

Avoid alcohol while using this medicine, as it might increase side effects and potentially harm your liver.

How fast does Adival 500 MG Tablet Er 10 start working?

The time it takes for this medicine to work varies depending on what you take it for. It could take weeks for epilepsy and bipolar disorder and possibly up to three months for preventing migraines.

Can I suddenly stop taking Adival 500 MG Tablet Er 10?

No, don't stop taking this medicine suddenly. Always consult your doctor for guidance on gradually reducing your dosage to avoid withdrawal symptoms.

Should I take Adival 500 MG Tablet Er 10 if I'm pregnant?

If you're pregnant, avoid taking Adival 500 MG Tablet Er 10, as it may cause birth defects or developmental problems in the fetus. Always consult your doctor before starting any medication.

Does Adival 500 MG Tablet Er 10 interact with other medicines?

Yes, Adival 500 MG Tablet Er 10 can interact with certain medicines, such as aspirin, antibiotics, anticonvulsants, blood thinners, and others. Let your doctor know about all the other medicines you are currently taking.

Last Updated On 13 May. 2025 | 11:19AM (IST)

Certified Content

Written by

Dr. Divya Chauhan

Medical Content Writer & Reviewer | 7 years

BAMS, APG, PG

Reviewed by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Check out Editorial Policy

Manufacturer details

ALMAR APARTMENT, SHOP NO. 4 FR. JUSTIN D'SOUZA ROAD, ORLEM, MALAD (W) MUMBAI Mumbai City MH 400064 IN

Expiry on or after: September 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

U.S. Food and Drug Administration. (n.d.). NDA 20-592/S-019. https://www.fda.gov/media/71427/download. Accessed 1 April 2024.
Stoner SC, Dahmen MM. Extended-release divalproex in bipolar and other psychiatric disorders: A comprehensive review. Neuropsychiatr Dis Treat. 2007 Dec;3(6):839-46. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656326/
Schwartz TL, Massa JL, Gupta S, Al-Samarrai S, Devitt P, Masand PS. Divalproex Sodium Versus Valproic Acid in Hospital Treatment of Psychotic Disorders. Prim Care Companion J Clin Psychiatry. 2000 Apr;2(2):45-48. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC181204/
Valproic acid: MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a682412.html

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