Zyvana M2 Forte Tablet 15

Converge Biotech Pvt Ltd

Strip of 15 Units

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Composition

Glimepiride (2 Mg) + Metformin (1000 Mg)

Zyvana M2 Forte Tablet 15 is used to manage type 2 diabetes in adults when diet, exercise, and single-agent therapies do not effectively control blood sugar levels. By combining two active ingredients, this medication helps improve glycemic control by reducing both fasting and post-meal glucose levels. It is most effective when part of a comprehensive diabetes care plan, which includes a balanced diet, regular physical activity, and weight management.

Before starting this medication, it is important to consult your doctor for the correct dosage based on your health condition. Be sure to inform your healthcare provider about any pre-existing conditions or medications you are currently taking. If any side effects occur while using this medicine, notify your doctor immediately. Continue taking the medicine as prescribed to achieve optimal results.

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Zyvana M2 Forte Tablet 15 is prescribed for the management of type 2 diabetes. This medication helps lower blood sugar by stimulating insulin secretion and improving insulin sensitivity, assisting in better control of blood glucose levels and reducing the risk of diabetes-related complications.

Swallow the tablet whole with water during breakfast or your first main meal of the day.
Do not crush, chew, or split the tablet, as this can affect its extended-release properties.
Always follow your doctor's recommendations regarding the dose and duration of use.

Zyvana M2 Forte Tablet 15 is taken orally.

Zyvana M2 Forte Tablet 15 may have the following common side effects:

Hypoglycaemia: This is a condition where your blood glucose levels may drop too low.
Gastrointestinal disturbances: You might experience nausea, vomiting, diarrhoea or abdominal pain.
Headache
Taste disturbances

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Zyvana M2 Forte Tablet 15. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypoglycaemia: Ensure you have regular meals to maintain stable blood glucose levels.
Gastrointestinal disturbances: Take Zyvana M2 Forte Tablet 15 with meals to help manage these symptoms.

Zyvana M2 Forte Tablet 15 comprises two active ingredients that work together to control blood glucose levels:

Glimepiride (2 mg): Glimepiride belongs to a class of medications known as sulfonylureas. It stimulates the pancreatic beta cells, which are responsible for producing insulin. This process increases the release of insulin into your body, helping lower blood sugar levels. Additionally, it enhances insulin sensitivity in peripheral tissues.
Metformin (1000 mg): Metformin is a biguanide that reduces glucose production in the liver and decreases glucose absorption in the intestine. It also improves insulin sensitivity by aiding peripheral glucose uptake and utilisation, which helps your body use up the sugar in your blood more effectively.

The combined action of these two ingredients provides effective and prolonged control of blood glucose levels.

Pregnancy

Caution is advised while taking Zyvana M2 Forte Tablet 15 if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

If you're breastfeeding, the components of Zyvana M2 Forte Tablet 15 can pass into your milk. Discuss the potential benefits and risks with your doctor.

Alcohol

Since alcohol can enhance the risk of lactic acidosis, it's advisable to avoid excessive alcohol intake while using Zyvana M2 Forte Tablet 15.

Liver

Elderly patients or those with liver health issues should take this medicine cautiously. It's best to discuss any liver-related concerns with your doctor before starting treatment.

Kidney

This medicine is not recommended if you have severe kidney problems. For those with mild to moderate kidney health issues, it's best to consult your doctor before starting this medication.

Using Machines & Driving

Zyvana M2 Forte Tablet 15 has no known impact on your ability to operate machinery or drive. However, be mindful of how you react to the medication before undertaking such tasks.

Allergy

Zyvana M2 Forte Tablet 15 is not suitable for individuals allergic to glimepiride, metformin, or any other ingredients in this medicine. If you have known allergies, discuss them with your doctor before starting this medication.

Children

The safety and effectiveness of Zyvana M2 Forte Tablet 15 for children have not been well-established. Therefore, caution is advised when giving this medicine to anyone under 18 years of age.

Older Patients

Older patients should take Zyvana M2 Forte Tablet 15 under medical supervision as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Zyvana M2 Forte Tablet 15 interacts with the following medicines:

Other anti-diabetic agents: Medicines like insulin and gliclazide, when taken with Zyvana M2 Forte Tablet 15, may increase the risk of low blood sugar or hypoglycaemia.
Thiazide diuretics: Medications such as hydrochlorothiazide and indapamide can increase blood sugar levels, affecting the effectiveness of Zyvana M2 Forte Tablet 15.
Corticosteroids: Medicines like hydrocortisone may increase blood glucose levels, potentially reducing the effectiveness of this medication.
Oral contraceptives and estrogens: These can cause a rise in blood glucose levels, which might reduce the efficacy of this tablet.

Drug-Food Interactions

There are no specific known food interactions with Zyvana M2 Forte Tablet 15.

Drug-Disease Interactions

Zyvana M2 Forte Tablet 15 interacts with the following diseases:

Type 1 diabetes: As it is designed to manage type 2 diabetes mellitus, patients with type 1 diabetes should not use this medicine.
Diabetic ketoacidosis: This medicine is contraindicated in patients with this condition as it could worsen their health status.
Severe renal impairment: The use of this medicine could exacerbate conditions related to kidney function.
Metabolic acidosis: Patients with metabolic acidosis should avoid this medication due to the risk of lactic acidosis.

Daily Dose

Take your daily dose of Zyvana M2 Forte Tablet 15 as prescribed by your doctor. The dose may vary depending on individual factors, such as the severity of your condition and your response to the medicine. Always adhere to the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

Taking more than the recommended dosage of Zyvana M2 Forte Tablet 15 could lead to common symptoms such as nausea, vomiting, and abdominal pain. If you suspect an overdose, inform your doctor promptly.

Missed Dose

If you forget to take a dose of Zyvana M2 Forte Tablet 15, take it as soon as you remember. If it's nearly time for your next dose, skip the missed one and go back to your regular dosage schedule. Don't increase your dosage without consulting your doctor.

Store Zyvana M2 Forte Tablet 15 at room temperature.
Protect the medicine from exposure to direct sunlight and moisture.
Keep this medication in a secure place, out of the reach of children.

Regular physical activity: Incorporating moderate exercise into your daily routine can help manage blood sugar levels. This could include brisk walking, cycling or swimming.
Balanced diet: A diet low in refined sugars and high in fibre can help control type 2 diabetes. This includes eating more whole grains, fruits, vegetables, and lean proteins while limiting sugary drinks and snacks.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 diabetes
Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Antidiabetic

What is Zyvana M2 Forte Tablet 15 used for?

Zyvana M2 Forte Tablet 15 is used to manage type 2 diabetes mellitus in adults, along with a proper diet and regular exercise.

How does Zyvana M2 Forte Tablet 15 work?

It contains two active ingredients that lower blood glucose levels in different ways: glimepiride stimulates insulin production, and metformin reduces glucose production in the liver.

Can I stop taking Zyvana M2 Forte Tablet 15 if my sugar levels are under control?

You should not stop taking this medicine without consulting your doctor. Stopping abruptly might cause your sugar levels to rise again.

What happens if I miss a dose of Zyvana M2 Forte Tablet 15?

Take the missed dose as soon as you remember, but if it's almost time for your next dose, skip the missed one. Never take two doses at once.

Can I take Zyvana M2 Forte Tablet 15 with other medicines?

Yes, but inform your doctor about all the medicines you're currently taking because some can interact with Zyvana M2 Forte Tablet 15.

What are the side effects of Zyvana M2 Forte Tablet 15?

Common side effects include hypoglycemia (low blood glucose), abdominal pain, nausea, vomiting and taste disturbances. If you experience any side effects, consult your doctor immediately.

How should I store the Zyvana M2 Forte Tablet 15?

Store this medicine at room temperature away from light and moisture. Keep it out of reach of children.

Last Updated On 14 Nov. 2025 | 9:37AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Divya Chauhan

Medical Content Writer & Reviewer | 7 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

7-2-1813/5/a1 UNo 1 ,2nd floor, Classic Arcade Rd, Czech Colony, Sanath Nagar IE, Sanath Nagar, Hyderabad, Telangana 500018

Country of origin: INDIA

Expiry on or after: March 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

DailyMed METFORMIN HYDROCHLORIDE tablet, extended release. (n.d.). https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1200ea71-8a9e-4e49-bb77-7d9fe0d84ae7
Unknown. (n.d.). GLUMETZA: Metformin Hydrochloride Extended Release Tablets Description, Clinical Pharmacology, Pharmacokinetics, Special Populations. https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021748s002lbl.pdf
Langtry, H. D., & Balfour, J. A. (1998). Glimepiride. Drugs, 55(4), 563–584. https://doi.org/10.2165/00003495-199855040-00007
HIGHLIGHTS OF PRESCRIBING INFORMATION. (2023). [Prescribing information]. In FARXIGA (Vols. 5–10, pp. 1–2). https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/202293s030lbl.pdf
Glimepiride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00222
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

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