Migrest Insta 20/500 MG Tablet 10

Tidal Laboratories Pvt Ltd

Pack of 10 Units

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Composition

Domperidone (20 Mg) + Paracetamol/acetaminophen (500 Mg)

Migrest Insta 20/500 MG Tablet 10 is used for symptomatic relief during migraine episodes. It combines Domperidone (to manage nausea and vomiting) and Paracetamol (to alleviate fever and pain). This combination is highly effective for migraine episodes, which are often characterized by neurological distress and sensitivity to stimuli.

Use this medication under the guidance of a healthcare professional. Follow the prescribed dosage and frequency to ensure effective management and avoid potential side effects.

Migrest Insta 20/500 MG Tablet 10 is primarily used for the symptomatic treatment of migraine headaches with associated nausea, vomiting, and pain. The combination contains domperidone effectively prevents nausea and vomiting while improving gastric motility. Paracetamol relieves pain and fever associated with migraine attacks.
It is important to note that the Migrest Insta 20/500 MG Tablet 10 is not a preventative medication for migraine headaches. It is used to treat the symptoms of an active migraine attack. If you experience frequent or severe migraine headaches, you should speak with your doctor about preventative treatment options.

It is essential to follow your doctor's prescribed dose and duration when taking Migrest Insta 20/500 MG Tablet 10s.
Swallow the tablet whole without chewing, crushing, or breaking it.
It is recommended to take Migrest Insta 20/500 MG Tablet 10s on an empty stomach.

The Migrest Insta 20/500 MG Tablet 10 is administered orally, and it is crucial to adhere to the instructions provided by your healthcare provider or as specified in the package insert.
If you have any doubts regarding the suitable dosage or how to take medicine, it is advisable to consult your physician or pharmacist for guidance.

Typical Migrest Insta 20/500 MG Tablet 10s side effects include

Dry mouth
Diarrhoea
Sleepiness
Tiredness
Skin rash

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing Migrest Insta 20/500 MG Tablet 10s. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

The Migrest Insta 20/500 MG Tablet 10 composition includes two active ingredients, Domperidone and Paracetamol, which work in different ways to alleviate symptoms of migraine, nausea/vomiting, and fever/pain.
Domperidone is a dopamine antagonist that acts on the brain's chemoreceptor trigger zone (CTZ), blocking the dopamine receptors. The CTZ is responsible for regulating nausea and vomiting, and Domperidone prevents activation of the CTZ by blocking dopamine receptors in this area, thus reducing the feeling of nausea and preventing vomiting.
On the other hand, Paracetamol is a pain reliever and fever reducer that works by inhibiting the production of prostaglandins, which are involved in the inflammation process and cause pain and fever. Paracetamol works primarily in the central nervous system (CNS), where it inhibits the action of cyclooxygenase (COX), an enzyme responsible for producing prostaglandins. By inhibiting COX, Paracetamol reduces the production of prostaglandins, thus reducing pain and fever.
The combination of Domperidone and Paracetamol in the Migrest Insta 20/500 MG Tablet 10 works together to provide symptomatic relief of migraine, nausea/vomiting, and fever/pain. Domperidone helps reduce nausea and vomiting, while Paracetamol reduces fever and pain. The precise mechanism of action of the combination of these two drugs is not fully understood, but their synergistic action enhances their personal effects, providing more significant relief of symptoms.
The Migrest Insta 20/500 MG Tablet 10 targets two different mechanisms involved in the development of migraine, nausea/vomiting and fever/pain. Domperidone acts on the CTZ to reduce nausea and vomiting, while Paracetamol inhibits the production of prostaglandins, reducing pain and fever. The combination of these two drugs provides effective relief of the symptoms associated with various medical conditions.

Pregnancy

It is advisable to consult a doctor before taking the Migrest Insta 20/500 MG Tablet 10 during pregnancy. The medication's safety during pregnancy is unclear and not recommended during the first trimester.

Breastfeeding

Consult a doctor before taking the Migrest Insta 20/500 MG Tablet 10 during breastfeeding. The medication's safety during lactation is unclear and not recommended unless deemed necessary by a healthcare professional.

Alcohol

It is advisable to avoid consuming alcohol while taking the Migrest Insta 20/500 MG Tablet 10. Alcohol may increase the risk of side effects such as drowsiness and dizziness.

Liver

Patients with liver disease should exercise caution while taking the Migrest Insta 20/500 MG Tablet 10. Dose adjustment may be necessary in such cases, and regular monitoring of liver function may also be required.

Kidney

The Migrest Insta 20/500 MG Tablet 10 should be used cautiously in patients with kidney disease. It may be necessary to adjust the dosage in such cases, and regular monitoring of kidney function may also be required.

Use In Driving And Operating Machinery

The Migrest Insta 20/500 MG Tablet 10 may cause drowsiness, dizziness, and blurred vision, impairing the ability to operate machinery or drive. It is advisable to exercise caution while performing such activities.

Allergy

Individuals with a history of an allergic reaction to any of the components of the Migrest Insta 20/500 MG Tablet 10 should avoid taking the medication.

Children

The safety and effectiveness of the Migrest Insta 20/500 MG Tablet 10 in children below 12 years of age have not been established. It is advisable to consult a doctor before administering the medication to children.

Older Patients

Older patients may be more susceptible to the side effects of the Migrest Insta 20/500 MG Tablet 10. Dose adjustment may be necessary in such cases, and regular kidney and liver function monitoring may also be required.

Drug-Drug Interactions

Migrest Insta 20/500 MG Tablet 10 may interact with the following medicines:

Amiodarone
Dronedarone
Quinidine
Sotalol
Diltiazem
Verapamil
Erythromycin
Clarithromycin
Moxifloxacin
Cisapride
Dolasetron
Warfarin
Metoclopramide
Cholestyramine

Drug-Disease Interactions

ku_name# can interact with conditions/diseases, including

Liver disease
History of gastrointestinal bleeding
Any problem involving the bowels

Daily Dose

The physician determines the dosage and administration schedule of the Migrest Insta 20/500 MG Tablet 10, considering the patient's age, body weight, health condition, and treatment response.
Healthcare professionals usually recommend taking a single daily dose.
It is crucial to follow the prescribed regimen strictly as directed by the doctor.

Over Dose

It is crucial to exercise caution to ensure your well-being and prevent any unfavourable effects of consuming a higher than the prescribed amount of Migrest Insta 20/500 MG Tablet 10.
Going beyond the recommended dose can result in symptoms such as stomach pain, loss of appetite, nausea, vomiting, agitation, unconsciousness, confusion, fits, sleepiness, and pale skin.

Missed Dose

If you forget to take a dose of the Migrest Insta 20/500 MG Tablet 10, take it as soon as you recall. However, if it is almost time for your next scheduled dose, skip the missed dose and stick to your regular dosing regimen.
Taking a double dose to compensate for a missed one is not recommended.

Store Migrest Insta 20/500 MG Tablet 10 in a cool, dry place.
Keep the tablets in their original packaging until you are ready to use them.
Do not expose the tablets to direct sunlight or heat sources, such as radiators or stoves.
Keep them away from moisture and humidity, as they may become less effective.
Store the tablets in a place that is out of the reach of children and pets to prevent accidental ingestion or damage.
Check the expiration date on the packaging before using the tablets, and do not use them if they are expired.

Establish regular meal times and try to stick to them every day. Skipping meals or having irregular eating patterns can trigger migraines in some individuals. Aim for a balanced diet that includes a mix of whole grains, lean proteins, fruits, and vegetables to provide stable energy levels throughout the day.
Keep a food diary to track what you eat and when migraines occur. Identify potential trigger foods, which can vary among individuals but may include items like chocolate, caffeine, aged cheeses, processed meats, and certain additives. Once identified, try to eliminate or limit these triggers from your diet.
Dehydration is a common trigger for migraines, so it's important to stay well-hydrated. Drink an adequate amount of water throughout the day. Avoid excessive consumption of caffeinated and sugary beverages, as they can contribute to dehydration and may act as migraine triggers for some people.
Consistent and sufficient sleep is crucial for migraine management. Aim for 7-9 hours of quality sleep per night. Establish a regular sleep routine by going to bed and waking up at the same time each day. Create a comfortable sleep environment, minimizing noise and light, to improve the quality of your sleep.
Stress is a common trigger for migraines, so it's important to find effective stress management techniques. Consider incorporating activities such as meditation, deep breathing exercises, yoga, or regular physical activity into your routine. These practices can help reduce stress levels and may contribute to a decrease in the frequency and severity of migraines.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Migraine headache
Drug Category	Dopamine antagonist
Therapeutic Category	Anti-emetic, analgesic

Does the Migrest Insta 20/500 MG Tablet 10 make you sleepy?

Yes, one of the common side effects of the Migrest Insta 20/500 MG Tablet 10 is sleepiness.

Can we take the Migrest Insta 20/500 MG Tablet 10 daily?

A doctor should determine the frequency of taking the Migrest Insta 20/500 MG Tablet 10, which should only be taken as prescribed.

What is the age limit for the Migrest Insta 20/500 MG Tablet 10?

The age limit for taking a Migrest Insta 20/500 MG Tablet 10 may vary based on individual circumstances, and it should only be taken under the guidance of a doctor.

Is the Migrest Insta 20/500 MG Tablet 10 addictive?

The Migrest Insta 20/500 MG Tablet 10 is not known to be habit-forming.

What is Migrest Insta 20/500 MG Tablet 10 used for?

Migrest Insta 20/500 MG Tablet 10 is used to treat migraine, nausea, and associated headaches. It combines pain relief with anti-nausea properties for better relief. The medicine helps reduce migraine intensity and discomfort.

Last Updated On 30 Mar. 2026 | 5:52PM (IST)

Certified Content

Written by

Dr. Nikhil Ambatkar

Medical Content Reviewer | 8 years

PhD (Biotechnology)

Reviewed by

Dr. Sachin Singh

Medical Team Lead & Reviewer | 7 years

MBBS

Check out Editorial Policy

Manufacturer details

Unit Number A-101, Ghatkopar Industrial Estate, Off. Lal Bahadur Shastri Marg, Ghatkopar, Amrut Nagar, Ghatkopar West, Mumbai, Maharashtra 400086

Country of origin: INDIA

Expiry on or after: August 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Domperidone. (2016, January 1). Elsevier eBooks. https://doi.org/10.1016/b978-0-444-53717-1.00654-5
Paracetamol Uses, Dosage, Side Effects, Warnings. (n.d.). Drugs.com. https://www.drugs.com/paracetamol.html
MacGregor, E. A., Wilkinson, M., & Bancroft, K. (1993). Domperidone plus paracetamol in the treatment of migraine. Cephalalgia: an international journal of headache, 13(2), 124–127. https://doi.org/10.1046/j.1468-2982.1993.1302124.x
U.S. Food and Drug Administration. (n.d.). Information about domperidone. Retrieved August 14, 2025, from https://www.fda.gov/drugs/information-drug-class/information-about-domperidone

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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