Gluconil Mf 5/500mg Tablet 10

Acron Pharmaceuticals

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Composition

Glipizide (5 Mg) + Metformin (500 Mg)

Gluconil Mf 5/500mg Tablet 10 is used to manage blood sugar levels in individuals with type 2 diabetes. It combines two active ingredients that work together to improve insulin sensitivity, reduce glucose production in the liver, and help regulate blood sugar levels after meals. This medicine belongs to the class of anti-diabetic medicines.

In addition to controlling blood sugar levels, this medicine also works to enhance the efficacy of insulin in the body, improving the overall management of diabetes.

Before starting with this medicine, it's recommended to consult your doctor to determine the appropriate dosage and frequency as per your health condition. Be sure to inform your doctor if you have any pre-existing diseases or if you're currently taking any other medications. If you notice any side effects while using this medicine, notify your doctor immediately. It's important to continue taking the medicine for the duration prescribed by your doctor for optimal results.

Gluconil Mf 5/500mg Tablet 10 is used for managing type 2 diabetes in adults

To use Gluconil Mf 5/500mg Tablet 10, follow these steps:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Gluconil Mf 5/500mg Tablet 10 is taken orally.

Gluconil Mf 5/500mg Tablet 10 may cause the following common side effects:

Hypoglycaemia: This is when your blood sugar drops too low, and you might feel shaky, sweaty, or hungry.
Diarrhoea
Nausea/vomiting
Abdominal pain
Headache
Dyspepsia: This is a fancy term for indigestion, which may make you feel bloated or uncomfortable.
Flatulence: You might experience more gas than usual.
Dizziness
Asthenia: This means you may feel weak or tired.
Anorexia: A decrease in your appetite.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve by discontinuing the use of Gluconil Mf 5/500mg Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips for managing common side effects:

Hypoglycaemia: If you feel shaky or hungry between meals, it might be due to low blood sugar. Try having a small snack or fruit juice to balance it out.
Dyspepsia: If you have indigestion, take this medicine after light meals to lessen this effect.

Gluconil Mf 5/500mg Tablet 10 is a combination medicine consisting of two active ingredients:

Glipizide (5 mg): As part of the sulfonylurea class of anti-diabetic medicines, glipizide works by stimulating the pancreas to secrete more insulin. This action helps to reduce blood sugar levels. Glipizide also increases the sensitivity of peripheral tissues to insulin, promoting better glucose uptake and utilisation.
Metformin (500 mg): Belonging to the biguanide class of medications, metformin works in three ways. It lowers hepatic glucose production, decreases the intestinal absorption of glucose, and improves insulin sensitivity by boosting peripheral glucose uptake and utilisation. Unlike sulfonylureas, metformin doesn't cause hypoglycaemia in patients with type 2 diabetes or in healthy individuals.

Pregnancy

Gluconil Mf 5/500mg Tablet 10 should not be used during pregnancy unless clearly necessary. It's best to consult your doctor before taking this medicine if you are pregnant or planning to conceive.

Breastfeeding

If you are breastfeeding, caution is advised. Consult your doctor before using this medicine.

Alcohol

Excessive alcohol intake can increase the risk of lactic acidosis, a serious complication associated with metformin, one of the components of Gluconil Mf 5/500mg Tablet 10. Consult your doctor for advice on alcohol consumption while taking this medicine.

Liver

Severe liver impairment is a contraindication for Gluconil Mf 5/500mg Tablet 10. If you have liver problems, it's important to discuss them with your doctor before starting this medicine.

Kidney

Gluconil Mf 5/500mg Tablet 10 is contraindicated in patients with renal disease or dysfunction. If you have a history of kidney problems, please consult your doctor before starting treatment.

Using Machines & Driving

There are no specific precautions regarding the use of machines or driving when taking Gluconil Mf 5/500mg Tablet 10. However, if you experience side effects like dizziness or low blood sugar, avoid driving or operating machinery until you feel well enough.

Allergy

If you have known hypersensitivity to glipizide, metformin, or any excipients in Gluconil Mf 5/500mg Tablet 10, avoid taking this medicine. Discuss any known allergies with your doctor before starting treatment.

Children

Caution is advised when considering this medication for individuals under 18 years of age.

Older Patients

Older patients should take Gluconil Mf 5/500mg Tablet 10 under medical supervision as they may be more susceptible to its side effects. If you are above 65 years of age, your doctor will guide you based on your health status. Regular assessment of renal function is necessary in this population.

Drug-Drug Interactions

Gluconil Mf 5/500mg Tablet 10 interacts with the following medicines:

NSAIDs: Medicines like ibuprofen and naproxen may increase the risk of hypoglycemia when taken with Gluconil Mf 5/500mg Tablet 10 due to the displacement of Glipizide from serum proteins.
Cationic medicines: Medicines such as amiloride, digoxin, and quinine might interact with Metformin in Gluconil Mf 5/500mg Tablet 10. Cationic drugs carry a positive charge (cation) at physiological pH, which can influence their absorption, distribution, and excretion within the body. These medicines compete for common renal tubular transport systems, potentially altering the effectiveness or enhancing side effects of the medication.

Drug-Food Interactions

Foods rich in fibre could potentially reduce the absorption of Metformin, decreasing its effectiveness in managing blood glucose levels.

Drug-Disease Interactions

Gluconil Mf 5/500mg Tablet 10 interacts with the following diseases:

Renal disease: Patients with kidney problems should avoid Gluconil Mf 5/500mg Tablet 10 as Metformin is primarily excreted by the kidneys and can exacerbate renal dysfunction.
Liver disease: Those with liver conditions should be cautious as Glipizide can cause adverse effects in patients with liver impairment.
Metabolic acidosis: People with metabolic acidosis, including diabetic ketoacidosis, should avoid Gluconil Mf 5/500mg Tablet 10 as Metformin usage may increase lactic acid levels in the blood.
Hypoglycaemia: Gluconil Mf 5/500mg Tablet 10 may increase hypoglycemic risks, particularly in elderly patients or those suffering from malnutrition or adrenal insufficiency.

Daily Dose

Your doctor will prescribe the exact daily dose of Gluconil Mf 5/500mg Tablet 10 for you. This depends on factors like your condition's severity and your response to the medicine. It's crucial to stick to this prescribed dosage and not to increase it without consulting your doctor.

Over Dose

If you accidentally take more Gluconil Mf 5/500mg Tablet 10 than prescribed, you might experience symptoms like low blood sugar (hypoglycemia). If this happens, consume oral glucose immediately. However, if you continue to feel unwell, inform your doctor.

Missed Dose

If you forget a dose of Gluconil Mf 5/500mg Tablet 10, take it as soon as you remember. But if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without consulting your doctor.

Keep Gluconil Mf 5/500mg Tablet 10 at room temperature.
Store in a place protected from light and moisture.
Never expose this medicine to direct sunlight or damp conditions.
Make sure to place Gluconil Mf 5/500mg Tablet 10 out of the reach of children.
Always check the expiry date before using.

Regular physical activity can help manage your blood sugar levels. Try to aim for at least 30 minutes of moderate activity every day, like brisk walking or cycling.
A balanced diet is crucial when managing type 2 diabetes. Opt for foods low in sugar and high in fibre, such as whole grains, fruits, vegetables, and lean proteins. Don't forget to consult your doctor for more personalised advice.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	Anti-Diabetic
Therapeutic Category	Blood Glucose Regulator

What Is the Purpose of Gluconil Mf 5/500mg Tablet 10?

Gluconil Mf 5/500mg Tablet 10 is an oral medication used to manage blood sugar levels in adults with type 2 diabetes mellitus.

How Does Gluconil Mf 5/500mg Tablet 10 Work?

Gluconil Mf 5/500mg Tablet 10 combines two active ingredients, glipizide and metformin, which work together to reduce blood sugar levels effectively.

Can Gluconil Mf 5/500mg Tablet 10 Cause Hypoglycaemia?

Yes, one of the active ingredients, glipizide, can cause hypoglycaemia or low blood sugar, especially in elderly or malnourished patients.

Is Gluconil Mf 5/500mg Tablet 10 Suitable for Pregnant Women?

Pregnant women should avoid taking Gluconil Mf 5/500mg Tablet 10 unless clearly necessary and recommended by a doctor.

What Should I Do If I Overdose on Gluconil Mf 5/500mg Tablet 10?

Overdosing can lead to serious complications like hypoglycaemia or lactic acidosis. Seek immediate medical attention if you suspect an overdose.

Can I Split or Crush Gluconil Mf 5/500mg Tablet 10?

No, tablets should be swallowed whole. They should not be crushed, cut or chewed.

How Should I Store My Gluconil Mf 5/500mg Tablet 10?

Store your tablets at room temperature and protect them from light and moisture. Always keep out of the reach of children.

Last Updated On 22 Aug. 2025 | 12:08PM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

23 MADHUMILAN ESTATE OPPMADHUR MASALA MAIN ROAD GIDC ESTATE NARODA AHMEDABAD GJ 383330 IN

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Pfizer, Inc. (2021). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/020329Orig1s035lbl.pdf
DailyMed - GLIPIZIDE ER- glipizide tablet, film coated, extended release. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a430577c-f233-40a7-bfd8-3d2bc6f98aa2
Glipizide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01067
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
DailyMed - METFORMIN ER 500 MG tablet METFORMIN ER 750 MG tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b857eccf-b9ff-45ba-8241-f47f5caada2a

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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CIN: U62099MH2019PTC320566

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