Sugar Substitutes for People with Diabetes: Weighing the Pros and Cons

Managing sugar intake is essential for people with diabetes to maintain healthy blood glucose levels. Fortunately, you don’t have to give up sweetness entirely. Natural and artificial sugar substitutes can offer the taste you love, without the rapid blood glucose spike.

Let’s learn about the safest and most effective sugar alternatives for people with diabetes, including high-intensity sweeteners like stevia, monk fruit, erythritol, and more. Discover how each option affects blood sugar levels, which ones to approach with caution, and how to select the best sweetener for your specific needs.

7 Sugar Substitutes for People Living with Diabetes

For individuals with diabetes, managing sugar intake is crucial, and selecting the right sugar substitutes can help maintain healthy blood glucose levels without compromising sweetness. These alternatives, often low or zero-calorie, are typically categorised as nutritive (e.g., sugar alcohols) or non-nutritive/high-intensity (e.g., sucralose, stevia) [1].

1. High-Intensity Artificial Sweeteners (Sucralose, Aspartame, & More)

Artificial sweeteners, which include non-nutritive sweeteners such as saccharin, aspartame (e.g., Equal), and sucralose (e.g., Splenda), are typically zero-calorie and do not directly raise blood sugar levels because they are many times sweeter than sugar and used in tiny amounts [2]. However, their long-term benefits for diabetes management are debated. Some observational studies suggest an association between high intake of artificial sweeteners and a small increased risk of Type 2 diabetes, though a cause-and-effect relationship has not been established [1]. Consumption in moderation, as part of a balanced diet, is generally recommended [3].

2. Stevia: A Natural, Zero-Calorie Sweetener

Stevia is a natural, zero-calorie sweetener derived from the Stevia rebaudiana plant. High-purity steviol glycoside extracts are approved by the Food and Drug Administration (FDA) as Generally Recognized as Safe (GRAS) and do not affect blood glucose levels [4], making it a popular choice for individuals with diabetes. It is considered a non-nutritive sweetener.

3. Monk Fruit (Luo Han Guo): Another Natural Option

Monk fruit extract is a non-nutritive sweetener derived from the Siraitia grosvenorii fruit. It is intensely sweet, zero-calorie, and has a negligible impact on blood glucose levels. The active sweet components are mogrosides, which are generally well-tolerated and approved for use as a sugar alternative [4].

4. Erythritol: A Common Sugar Alcohol

Erythritol is a sugar alcohol that is a low-calorie sweetener often used in sugar-free products. It provides fewer calories than table sugar (about 0.2 calories per gram vs. 4 calories per gram) and does not significantly affect blood sugar levels, making it suitable for individuals with diabetes [5]. Like other sugar alcohols, consuming large amounts can cause gastrointestinal side effects such as bloating or diarrhoea [5].

5. Tagatose: A Rare Sugar

Tagatose is a natural monosaccharide (rare sugar) found in small amounts in some dairy products and fruits. It is about 92% as sweet as sugar but contains fewer calories (1.5 calories per gram) [6]. Due to its low glycemic index, it has potential benefits for managing blood sugar and insulin response, but current human research is limited and more clinical trials are needed to confirm its long-term efficacy in diabetes management [6].

6. Coconut Palm Sugar: Not a Low-Glycemic Substitute

Coconut palm sugar is a natural sweetener derived from the sap of the coconut palm flower. It contains some minerals and has a slightly lower glycemic index compared to table sugar (sucrose) [7]. However, it is not a low-calorie or non-glycemic substitute; it contains a similar amount of carbohydrates and calories as regular sugar (sucrose). Therefore, it should be used in moderation and counted as part of the total carbohydrate intake for people with diabetes.

7. Other Sweeteners to Note: Yacon Syrup and Advantame

• Yacon Syrup: Derived from the yacon plant, this syrup contains fructooligosaccharides (FOS), which act as prebiotics and are not digested, thus not raising blood sugar immediately. However, it still contains natural sugars and is high in calories (about 20 calories per tablespoon) [8]. Moderation is recommended for individuals with diabetes.
• Advantame: An intense, non-nutritive artificial sweetener, Advantame is approximately 20,000 times sweeter than sugar. It is approved for use by the FDA [4], but there is a lack of extensive independent research specifically on its long-term effects on glycaemic control in people with diabetes.

Choosing the Best Sweetener for Diabetes Management

Do you know that not all sugar substitutes are created equal?

The primary goal of choosing a substitute is to satisfy a sweet craving without negatively impacting blood glucose control. Non-nutritive sweeteners, both natural (Stevia, Monk Fruit) and artificial (Sucralose, Aspartame), achieve this because they don’t contain significant calories or carbohydrates [1]. However, emerging research suggests other factors may be at play:

• Gut Microbiota: Some studies suggest certain artificial sweeteners may alter the gut microbiota, which could indirectly affect glucose metabolism [3].
• Insulin Response: While not causing a direct blood sugar rise, some high-intensity sweeteners have been hypothesised to potentially trigger cephalic phase insulin release, though clinical data on this remains mixed and inconclusive [1].
• Appetite Regulation: Concerns exist that the intense sweetness without corresponding calories may disrupt the body’s natural satiety cues, though evidence is inconsistent.

Tips to Choose a Sweetener Wisely

When selecting a sweetener, it is essential to carefully consider your overall diet and potential individual impacts. Here are some key points to keep in mind:

• Prioritise Zero or Low-Calorie Options: Non-nutritive high-intensity sweeteners (Stevia, Monk Fruit, Aspartame, Sucralose) are the most effective for blood sugar control as they have negligible caloric or carbohydrate content.
• Evaluate Glycemic Effects: Choose substitutes with a minimal impact on blood glucose. Avoid options like honey, maple syrup, or coconut sugar, which still contribute significant carbohydrates.
• Consider Natural vs. Artificial: While natural options like stevia and monk fruit are often preferred and generally well-tolerated, approved artificial sweeteners are safe when consumed within the Acceptable Daily Intake (ADI) [4]. The best choice is often a personal one based on taste preference and tolerance.
• Read Labels Carefully: Be aware of ‘blended’ products, which may combine a non-nutritive sweetener with dextrose or maltodextrin, thus adding carbohydrates.

Pros and Cons of Common Sugar Alternatives for People with Diabetes

Here are some advantages and disadvantages of using common sugar substitutes to help you make an informed decision [4], [5].

Selecting the right sugar substitute is an individual aspect of diabetes management. While non-nutritive sweeteners like stevia and monk fruit are excellent, approved options, artificial sweeteners should also be considered safe when consumed within recommended guidelines. Always check the glycemic effects, be mindful of potential side effects, and most importantly, consult your doctor or a registered dietitian before making significant changes to your diet. With the right sweetener, you can enjoy sweetness without compromising your blood sugar control.

Expert Quote

“Not all sugar substitutes are created equal. While non-nutritive sweeteners like stevia and monk fruit have minimal impact on blood glucose levels, the long-term effects of any sweetener, natural or artificial, are subject to ongoing research. People with diabetes should prioritise options that support their overall metabolic health and always check ingredient labels for added carbohydrates.”

-Dr Anubha Karol

Frequently Asked Questions (FAQs)

Are sugar substitutes safe for long-term use?

Research on long-term safety is mixed. Regulatory bodies like the FDA and EFSA affirm that approved sugar substitutes are safe when consumed within the Acceptable Daily Intake (ADI) [4]. Some observational studies suggest potential risks or metabolic changes [1], while others show they can be safe and beneficial for weight control when consumed in moderation. It’s best to consult your doctor or a dietitian before relying on any sugar alternatives for long-term diabetes management.

Should those with diabetes avoid stevia?

High-purity stevia extract is generally safe for people with diabetes and is a well-regarded sugar alternative [4]. However, it should be used in moderation as part of a balanced diet. Consult your doctor to determine the best sugar substitute for your individual needs.

What is the safest sweetener for those with diabetes?

Non-nutritive sweeteners (both natural like stevia and monk fruit, and artificial like sucralose and aspartame) are effective for blood glucose management because they don’t contribute significant calories or carbohydrates [1]. Stevia and monk fruit are often preferred for their natural origins. Individual responses may vary, so consult your doctor for personalised recommendations.

Which is better for those with diabetes, Stevia or Splenda?

Both Stevia and Splenda (Sucralose) are non-nutritive sweeteners that do not raise blood glucose levels. Stevia is a natural extract, while Sucralose is an artificial high-intensity sweetener. Stevia is often considered a healthier alternative due to its antidiabetic properties observed in some studies [9]. However, both are generally safe when used in moderation. Consult your doctor to determine the best sugar substitute for your needs.

What are the side effects of using stevia?

Stevia can cause mild digestive issues (bloating, nausea), particularly if used in highly processed forms or in large amounts. The bitter aftertaste is also a common complaint. Consult your doctor before using stevia as a sugar substitute for persons with diabetes to avoid potential side effects.

What is the best substitute for sugar for people with diabetes?

Natural, non-nutritive options like high-purity stevia and monk fruit extract are frequently recommended as excellent alternatives for individuals with diabetes [4]. However, the best sugar substitute for individuals with diabetes varies from person to person based on taste, tolerance, and overall diet, so consult your doctor for personalised recommendations.

Is monk fruit sugar OK for people with diabetes?

Yes, monk fruit extract is safe for consumption in individuals with diabetes due to its zero-calorie content and non-effect on blood sugar levels, making it a suitable non-nutritive sugar substitute [4].

References

[1] Debras, C., Deschasaux-Tanguy, M., Chazelas, E., Sellem, L., Druesne-Pecollo, N., Esseddik, Y., De Edelenyi, F. S., Agaësse, C., De Sa, A., Lutchia, R., Julia, C., Kesse-Guyot, E., Allès, B., Galan, P., Hercberg, S., Huybrechts, I., Cosson, E., Tatulashvili, S., Srour, B., & Touvier, M. (2023). Artificial sweeteners and risk of Type 2 diabetes in the prospective NutriNet-Santé cohort. Diabetes Care, 46(9), 1681–1690. https://doi.org/10.2337/dc23-0206

[2] Arshad, S., Rehman, T., Saif, S., Rajoka, M. S. R., Ranjha, M. M. A. N., Hassoun, A., Cropotova, J., Trif, M., Younas, A., & Aadil, R. M. (2022). Replacement of refined sugar by natural sweeteners: focus on potential health benefits. Heliyon, 8(9), e10711. https://doi.org/10.1016/j.heliyon.2022.e10711

[3] Okoro, F. O., & Markus, V. (2025). Artificial sweeteners and Type 2 Diabetes Mellitus: A review of current developments and future research directions. Journal of Diabetes and Its Complications, 39(2), 108954. https://doi.org/10.1016/j.jdiacomp.2025.108954

[4] Rachmawati, P., & Noviani, L. (2023). EXPLORING NATURAL SUGAR SUBSTITUTES: CAN THEY BE a FRIENDLY DIET FOR TYPE 2 DIABETES MELLITUS? WEIGHING THE PROS AND CONS. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 2458. https://doi.org/10.53555/jptcp.v30i17.2458

[5] Mäkinen, K. K. (2016). Gastrointestinal disturbances associated with the consumption of sugar alcohols with special consideration of Xylitol: Scientific Review and Instructions for Dentists and Other Health-Care Professionals. International Journal of Dentistry, 2016, 5967907. https://doi.org/10.1155/2016/5967907

[6] Pereira, M. F., De Codes Soares, I., Cabral, M. M., De Freitas, P. A., Sousa, G. M. A., Magalhães, S. C., Carioca, A. a. F., De Oliveira, M. R. C., Magalhães, F. E. A., De Oliveira, A. C., Farias-Pereira, R., & De Oliveira, K. A. (2025). Impacts of Yacon Syrup (Smallanthus sonchifolius) on Human Health: A Systematic Review of Scientific Evidence from the Last Decade. Nutrients, 17(5), 888. https://doi.org/10.3390/nu17050888

[7] Molecules. (n.d.). Sugar Substitutes (Special Issue). https://www.mdpi.com/journal/molecules/special_issues/Sugar_Substitutes

[8] Chupeerach, C., Yothakulsiri, C., Chamchan, R., Suttisansanee, U., Sranacharoenpong, K., Tungtrongchitr, A., & On-Nom, N. (2018). The Effect of Coconut Jelly with Stevia as a Natural Sweetener on Blood Glucose, Insulin and C-Peptide Responses in Twelve Healthy Subjects. Recent Patents on Food Nutrition & Agriculture, 9(2), 127–133. https://doi.org/10.2174/2212798410666180717163852

[9] Rachmawati, P., & Noviani, L. (2023). EXPLORING NATURAL SUGAR SUBSTITUTES: CAN THEY BE a FRIENDLY DIET FOR TYPE 2 DIABETES MELLITUS? WEIGHING THE PROS AND CONS. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 2458. https://doi.org/10.53555/jptcp.v30i17.2458