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Naproxen + Domperidone

Migraine Drugs

Uses of Naproxen + Domperidone

Naproxen + Domperidone is a combination medicine used for acute migraine attacks accompanied by nausea or vomiting.

This combination is commonly used for:

• Migraine headache: Relieves pain during an acute migraine attack.
• Migraine-associated nausea: Reduces nausea that commonly occurs with migraine.
• Migraine-associated vomiting: Helps control vomiting and may improve retention of the pain medicine.
• Migraine with delayed stomach emptying: Domperidone may improve gastric emptying and support absorption of Naproxen during an attack.

Side effects of Naproxen + Domperidone

  • Swelling on ankle/feet
  • Unusual tiredness
  • Mood changes
  • Hot flashes 
  • Confusion
  • Headache
  • Ringing in the ears 
  • Changes in sight

How Naproxen + Domperidone works

  • Naproxen + Domperidone combines an anti-inflammatory pain reliever with an anti-nausea medicine for acute migraine.
  • Naproxen is an NSAID that reduces prostaglandin production, helping relieve migraine pain and associated inflammation.
  • Domperidone blocks dopamine receptors involved in nausea and vomiting and increases movement of the upper digestive tract. This can reduce migraine-associated nausea and improve gastric emptying, which may support absorption of Naproxen.
  • The combination is intended for migraine with nausea or vomiting, not as a general treatment for all musculoskeletal or menstrual pain.

Certified content

Written By

docImg
Dr. Sachin SinghMedical Team Lead & Reviewer| 7 years

MBBS

Reviewed By

Dr. Mandeep Chadha
Dr. Mandeep ChadhaLead Medical Content Reviewer| 12 years

MBBS, DNB (OBGY)

Expert Advice

Dosage Forms Available

  • Naproxen + Domperidone can be taken orally (tablet).

Age And Dose Restrictions

  • It can be used by adults and children over 12 years of age.

Contraindications 

  • It is contraindicated in patients with a history of hypersensitivity to naproxen or domperidone, patients with kidney disease, heart disease, liver disease or asthma.

Medications To Avoid With This Drug 

  • Avoid taking anticoagulants (warfarin), NSAIDs (ketorolac), ACE inhibitors (ramipril), corticosteroids (prednisone), aminoglycoside antibiotics (amikacin), and antiarrhythmic medications (quinidine). These medications may alter the safety and effectiveness of this combination.

Overdose And Missed Dose

  • Taking more than the prescribed amount may cause symptoms such as extreme tiredness, stomach pain, heartburn, nausea, vomiting, drowsiness, and uncontrolled eye movements. In severe cases, confusion or difficulty breathing may occur. If you suspect an overdose, stop taking the medicine and seek immediate medical attention. Do not attempt to manage the overdose at home.
  • If you miss a dose of Naproxen + Domperidone, take it as soon as you remember. If it is nearly time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for the missed one.

Management Of Side Effects

  • The side effects are temporary and resolve when this combination is discontinued. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

  • This medicine can cause confusion. It is not recommended to drive, operate machinery, or do other activities that require mental alertness or coordination after taking this medicine. 

Use In Pregnancy And Lactation

  • Caution is advised in pregnant women. Its use in breastfeeding women should be done only if prescribed by a doctor.

Caution In Other Conditions

  • Caution should be taken in the elderly, especially in liver, kidney, and heart disease patients.

Special Dietary And Lifestyle Recommendation

  • Avoid skipping meals, as irregular eating patterns contribute to migraines.
  • Practice stress-relief techniques like meditation, yoga, deep breathing, and mindfulness to reduce migraine triggers.
  • Try sleeping in a dark room during the migraine episode.
  • Maintain a consistent sleep schedule and ensure you get restorative sleep each night.
  • Engage in regular physical activity but avoid excessive exertion during the migraine attack.
  • Apply a cold compress to your forehead for 15 minutes to ease the pain.
  • Apply gentle pressure to specific painful points on your head, neck, and shoulder to relieve the migraine headache. 

Disease/Condition Glossary

  • Migraine-Associated Vomiting or Nausea: Migraine-associated nausea or vomiting is a related sign of migraine. Extreme nausea or vomiting can lead to dehydration, difficulty eating, and reduced medication absorption. Treatment for such symptoms involves lifestyle changes, anti-nausea medication, and successful migraine management to reduce the frequency and severity of attacks.
  • Headache: Headache is a prevalent condition characterised by pain or discomfort in the head, scalp, or neck. If headaches are frequent or severe, they can be signs of underlying conditions such as migraines, tension-type headaches, or more serious neurological diseases. Effective management includes identifying triggers, using appropriate medications, and incorporating stress-reduction techniques and proper sleep hygiene.
  • Musculoskeletal Pain: Musculoskeletal pain is the pain in muscles, bones, ligaments, tendons, or nerves. It can be due to injury, overuse, improper body mechanics, arthritis or fibromyalgia disease. Treatment includes pain relief with medications, physical therapy, and addressing underlying causes to restore normal function.

Frequently asked questions

This combination is not recommended for use during pregnancy. Please consult your doctor before using this medicine and advice. 

This combination is not recommended for use while breastfeeding. Please consult your doctor before using this medicine and advice. 

The safety and efficacy of this combination have not been established in children under twelve years of age. Please consult your child’s doctor before using it in such children. 

Be cautious about using this combination in elderly people with liver, kidney, and cardiac diseases. Dosage adjustments may be required. Your doctor will check your history of illnesses, health and current body status and prescribe it accordingly.

Drowsiness and sleepiness may occur up to the intake of this combination. It is best to avoid using machines and driving until you feel normal again. 

No, this tablet is not a steroid. It belongs to the NSAIDs and anti-emetic group of medicines that are used for the treatment and prevention of migraine headaches. 

Naproxen + Domperidone is used to relieve migraine symptoms like headache, nausea, and vomiting. It also helps relieve pain associated with conditions like arthritis, gout, menstrual cramps, back pain, and sprains. Domperidone helps control nausea, making pain relief more effective.

Terms & Conditions


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