Domperidone + Omeprazole
Antiemetic/AntacidUses of Domperidone + Omeprazole
- Domperidone + Omeprazole is used in the treatment of Gastroesophageal Reflux Disease (GERD) when patients are not responding to omeprazole alone.
- It is also used in treating duodenal ulcers and gastric ulcers.
Side effects of Domperidone + Omeprazole
- Headache
- Diarrhoea
- Abdominal pain
- Flatulence
- Dry mouth
How Domperidone + Omeprazole works
- Domperidone, a dopamine antagonist with antiemetic properties, exhibits limited permeability through the blood-brain barrier. While extrapyramidal side effects are exceedingly rare in adult users, domperidone stimulates prolactin release from the pituitary. Its antiemetic efficacy may result from a blend of peripheral (gastrokinetic) actions and antagonism of dopamine receptors in the chemoreceptor trigger zone, situated beyond the blood-brain barrier in the area postrema.
- Omeprazole, a racemic blend of two enantiomers, diminishes gastric acid secretion via a precise mechanism. It is a inhibitor of the acid pump within the parietal cell. Rapid in onset, it ensures control through reversible inhibition of gastric acid secretion.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- This combination is available for use via the oral route (delayed-release tablets and suspension).
Age and Dose Restrictions
- The combination is meant for adults and children above 12 years of age.
Contraindications
- Domperidone + Omeprazole is contraindicated in patients with known allergies to domperidone or omeprazole, who have prolactinoma and severe liver issues.
Other Medications To Avoid With This Medicine
- It is advised against concurrent use of painkillers (aspirin), antibiotics (ciprofloxacin), statins (atorvastatin), anti-HIV medications (atazanavir), blood-thinning medications (clopidogrel, warfarin, cilostazol), levothyroxine for hypothyroidism, anti-fungal medications (ketoconazole, itraconazole, voriconazole), anti-cancer medications (erlotinib, methotrexate), anti-depressants (citalopram, escitalopram, duloxetine), anti-anxiety medications (alprazolam), vitamins (cyanocobalamin), anti-convulsants (phenytoin), gastroprokinetic medications (cisapride), cardiac glycosides (digoxin), immunosuppressants (tacrolimus), and anti-tuberculosis medications (rifampicin) along with Domperidone + Omeprazole. Prior consultation with your doctor is essential before initiating any prescription or over-the-counter medications.
Overdose and Missed Dose
- Overdose of this combination can cause confusion, drowsiness, blurred vision, tachycardia, nausea, vomiting, diaphoresis, flushing, headache, and dry mouth. Inform your doctor regarding these effects and follow the advice accordingly.
- If you forget to take this combination, take it as soon as you remember, but avoid repeating the dose.
Use In Driving And Operating Machinery
- This combination may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy after taking this combination.
Use in Pregnancy and Lactation
- This combination is not recommended during pregnancy or breastfeeding.
Special Dietary & Lifestyle Recommendation
- Avoid alcohol when you are taking Domperidone + Omeprazole.
- Individuals with a history of GERD should consider lifestyle modifications, including dietary changes such as adopting a GERD-friendly diet, emphasising low-acid foods, avoiding spicy and fatty meals, and reducing portion sizes in conjunction with this combination.
- It is best to take this combination before meals.
Frequently asked questions
1. How much time does Domperidone + Omeprazole take to work?
This combination starts showing its effect within a few hours after consumption.
2. What warnings and precautions should I take while taking Domperidone + Omeprazole?
Avoid taking this combination if you experience hypersensitivity or allergic reactions to any of its components. Promptly seek medical advice in such cases.
3. Can I stop taking Domperidone + Omeprazole if I feel healthy?
Do not stop taking this combination without consulting your doctor, even if you feel healthy.
4. Is it safe for patients with kidney or liver issues?
Consult your doctor before taking this combination if you have kidney or liver issues to ensure its safety and proper dosage.
Domperidone + Omeprazole in other salts
Subscribe
Claim your complimentary health and fitness tips subscription and stay updated on our newest promotions.
Download Truemeds
Manage your health with ease Download Truemeds today!Get easy access to medicine refills, health information, and more. With our app, you'll never have to wait in line again. Download now and start taking control of your health.
Contact Us
Our customer representative team is available 7 days a week from 9 am - 9 pm.
v2.5.2
2024 - Truemeds | All rights reservedOur Payment Partners
