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Domperidone + Esomeprazole

ANTIEMETIC/ANTACID

Uses of Domperidone + Esomeprazole

  • Domperidone + Esomeprazole are used to treat gastroesophageal reflux disease (acid reflux) and relieve indigestion symptoms such as heartburn, stomach pain, or irritation. 
  • These gastrointestinal agents work together to enhance digestive health and provide effective relief from discomfort associated with excessive stomach acid.

Side effects of Domperidone + Esomeprazole

  • Headache
  • Diarrhoea
  • Nausea 
  • Flatulence
  • Abdominal Pain
  • Constipation
  • Dry Mouth

How Domperidone + Esomeprazole works

  • Domperidone and esomeprazole are gastrointestinal agents.
  • Domperidone is a D2 receptor antagonist. It blocks dopamine receptors in the gastrointestinal tract. Blocking these receptors helps reduce symptoms such as nausea, vomiting, and digestive discomfort associated with gastrointestinal disorders.
  • Esomeprazole is a proton pump inhibitor (PPI). It reduces the production of stomach acid to relieve symptoms of excess stomach acids, such as heartburn, acid reflux, and stomach ulcers.

Certified content

Written By

docImg
Amit SharmaClinical Health & Medical Writer| 3 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • This combination can be taken orally (tablet and capsule).

Age and Dose Restrictions

  • This combination is intended to be used by adults only.

Contraindications

  • This combination is contraindicated in patients with a history of hypersensitivity to domperidone or esomeprazole or any other proton pump inhibitor medicines.

Medications to Avoid with This Drug

  • Avoid taking anticoagulants (clopidogrel and warfarin), immunosuppressants (methotrexate and tacrolimus), antifungals (ketoconazole and voriconazole), antibiotics (erythromycin, clarithromycin, rifampin and telithromycin), antiarrhythmics (amiodarone, dronedarone, and quinidine), antipsychotics (haloperidol, pimozide, and sertindole), antidepressants (citalopram and escitalopram), other gastrointestinal medications (cisapride, dolasetron, and prucalopride). These medications may alter the safety and effectiveness of this combination.

Overdose and Missed Dose

  • Overdose can cause confusion, drowsiness, blurred vision, increased heart rate, nausea, sweating, flushing, headache, dry mouth, and disorientation. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
  • If you miss a dose of this combination, take it as soon as you remember, but if the next dose is near, skip the missed dose and resume the regular dosing regime.

Management of Side Effects

  • Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

  • Taking this combination can make you feel dizzy. It is not recommended to drive, operate machinery, or do other activities requiring mental alertness or coordination after this combination. 

Use in Pregnancy and Lactation

  • Caution is advised while taking this combination during pregnancy. This combination is not recommended during breastfeeding.

Caution in Other Conditions

  • Caution is advised in older adults and patients with heart conditions, bone fractures, hypomagnesemia, gastrointestinal haemorrhage, prolactin-releasing pituitary tumour (prolactinoma) and severe liver impairment.

Special Dietary & Lifestyle Recommendation

  • This combination is typically recommended for short-term use to manage GERD symptoms. The prolonged use of this combination should not be done without consulting a doctor. 
  • Avoid alcohol, as drinking alcohol makes your stomach produce more acid than usual. It can irritate your stomach lining and make your symptoms worse.
  • Long-term use of proton pump inhibitors (PPIs) like esomeprazole may be associated with a risk of decreased calcium absorption. Ensure an adequate intake of calcium and vitamin D, either through diet or supplements, under the guidance of your doctor.
  • Avoid rushing through meals, and take your time to enjoy and properly digest your food.
  • Finish your last meal or snack at least two to three hours before bed. It allows the stomach to empty partially, reducing the likelihood of acid reflux while lying down.
  • Eat smaller, frequent meals instead of large meals. It helps reduce the amount of food in the stomach, decreasing the likelihood of acid reflux.

Frequently asked questions

Yes, this combination is effective for acidity as it helps improve stomach motility and reduces acid production.

This combination typically show their effects within 30 minutes to an hour after ingestion. However, individual responses may vary. 

No, this combination is not habit-forming and is generally safe when used as directed.

No, the use of this combination does not impair female fertility. However, it's best to consult your doctor for any concerns. 

This combination usually requires a prescription and is not available over the counter.

This combination may relieve pain for up to a few hours. However, the duration of effect of this medication can vary with the individual and the severity of the condition being treated.

No, this combination is not used for stomach pain.

It is best to take this combination on an empty stomach, preferably in the morning or at least 1 hour before the meal.

This combination can cause gastrointestinal haemorrhage. Therefore it is not recommended in patients with gastrointestinal haemorrhage or perforation.

This combination can be used to manage nausea associated with GERD.

Terms & Conditions


Available medicines for DOMPERIDONE + ESOMEPRAZOLE
Esomefol Dsr Capsule 10
Esomefol Dsr Capsule 10
Leeford Healthcare
Pack of 10 Units
₹47.41
MRP ₹95.00
50.10% OFF
Es Omepraz Dsr Capsule 10
Es Omepraz Dsr Capsule 10
Alkem Laboratories Ltd.
Pack of 10 Units
₹52.39
MRP ₹105.00
50.10% OFF
Sompraz D 40 Capsule 15
Sompraz D 40 Capsule 15
Sun Pharma Laboratories Ltd.
Pack of 15 Units
₹217.30
MRP ₹265.00
18.00% OFF
Omez D Sr+ Capsule 15
Omez D Sr+ Capsule 15
Dr. Reddys Laboratories Ltd
Pack of 15 Units
₹184.30
MRP ₹224.75
18.00% OFF
Esogress D Capsule 10
Esogress D Capsule 10
La Renon
Pack of 10 Units
₹115.62
MRP ₹141.00
18.00% OFF
Nexpro Rd 40 Capsule 10
Nexpro Rd 40 Capsule 10
Torrent Pharmaceuticals Ltd.
Pack of 10 Units
₹152.11
MRP ₹185.50
18.00% OFF
S Rd Capsule 15
S Rd Capsule 15
Blue Cross Laboratories Ltd
Pack of 15 Units
₹61.50
MRP ₹75.00
18.00% OFF
Esomifor Dsr Capsule 10
Esomifor Dsr Capsule 10
Ajanta Pharma Ltd
Pack of 10 Units
₹71.36
MRP ₹143.00
50.10% OFF

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