Domperidone + Rabeprazole

Dosage Forms Available for Domperidone + Rabeprazole

• This combination is available for use via the oral route (delayed-release tablets and capsules).

Age And Dosage Restrictions for Domperidone + Rabeprazole

• This combination is meant for adults.

Contraindications of Domperidone + Rabeprazole

• Domperidone + Rabeprazole is contraindicated in patients with known allergies to domperidone or rabeprazole, and in patients who have prolactinoma and severe liver issues.

Medications To Avoid With Domperidone + Rabeprazole

• Some medicines may need to be avoided when taken with Domperidone + Rabeprazole. These include medicines that may prolong the QT interval or potent CYP3A4 inhibitors, which can increase domperidone levels and the risk of serious heart rhythm problems. These may include certain antifungal medicines (such as ketoconazole, fluconazole, and voriconazole), certain antibiotics (such as clarithromycin and erythromycin), and some heart medicines such as amiodarone. Rabeprazole may also affect the absorption of certain medicines that depend on stomach acidity for absorption. Consult your doctor or pharmacist before starting any prescription, over-the-counter, or other medicine while taking Domperidone + Rabeprazole.

Overdose and Missed Dose

• An overdose of this combination may cause agitation, altered consciousness, convulsions, disorientation, excessive drowsiness, and movement-related symptoms (extrapyramidal reactions). If an overdose is suspected, seek immediate medical attention.
• If you forget to take this combination, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Use In Driving And Operating Machinery

• This combination may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy after taking this combination.

Use in Pregnancy and Lactation

• This combination should be used during pregnancy and breastfeeding only under a doctor's advice.

Special Dietary & Lifestyle Recommendation

• Avoid alcohol when you are taking Domperidone + Rabeprazole.
• Individuals with gastroesophageal reflux disease should contemplate lifestyle adjustments, incorporating dietary modifications such as adopting a GERD-friendly diet characterised by an emphasis on low-acid foods, avoidance of spicy and fatty meals, and reduction of portion sizes, all in conjunction with the administration of Domperidone + Rabeprazole.
• It is best to take this combination before meals.

Disease/Condition Glossary

• Acidity: The stomach is naturally lined with a protective mucous layer that shields it from its own acid. However, when this layer is damaged or when excessive acid is produced, it can lead to several complications such as Gastroesophageal reflux disease (GERD), heartburn, gastric ulcers, and Zollinger-Ellison syndrome. GERD happens when stomach acid repeatedly flows back into the oesophagus, causing irritation and symptoms like heartburn, a sour or bitter taste, and trouble swallowing. Gastric ulcers are painful sores on the stomach or intestinal lining, presenting symptoms such as nausea, indigestion, appetite changes, blood in stool, and weight loss. Zollinger-Ellison syndrome involves tumour growth in the upper small intestine, leading to high acid levels and symptoms like bloating, nausea, vomiting, and appetite loss.