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Esomeprazole + Naproxen

Uses of Esomeprazole + Naproxen

Esomeprazole + Naproxen is used to relieve pain and inflammation in conditions such as osteoarthritis and rheumatoid arthritis, while reducing the risk of stomach ulcers that can occur with long-term anti-inflammatory use. Naproxen is an NSAID that relieves pain and inflammation, and Esomeprazole is a proton pump inhibitor that reduces stomach acid.

This combination is commonly used for:

• Osteoarthritis: Relieves joint pain, stiffness, and inflammation caused by wear-and-tear arthritis.
• Rheumatoid arthritis: Eases pain, swelling, and inflammation associated with this autoimmune joint condition.
• Ankylosing spondylitis: Reduces pain and stiffness in the spine and joints caused by this inflammatory condition.
• Prevention of NSAID-related stomach ulcers: Reduces the risk of stomach ulcers in people who need long-term anti-inflammatory treatment.

Side effects of Esomeprazole + Naproxen

  • Gastritis

  • Nausea

  • Diarrhoea

  • Constipation

  • Abdominal pain

How Esomeprazole + Naproxen works

Esomeprazole + Naproxen works through two separate actions that together relieve pain while protecting the stomach.

Naproxen is an NSAID. It works by blocking enzymes called cyclooxygenase (COX-1 and COX-2), which the body uses to produce prostaglandins. Prostaglandins cause pain, swelling, and inflammation, so blocking their production reduces these symptoms. However, NSAIDs can also reduce the protective lining of the stomach, increasing the risk of ulcers.

Esomeprazole is a proton pump inhibitor. It works by blocking the enzyme responsible for producing stomach acid, which reduces the amount of acid in the stomach and helps protect against NSAID-related stomach ulcers.

Together, Naproxen relieves the underlying joint pain and inflammation while Esomeprazole helps protect the stomach from the risk of NSAID-related stomach ulcers that can occur with long-term NSAID use.

Certified content

Written By

docImg
Dr Nikita LoboMedical Content Reviewer| 9 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi RoshaMedical Content Writer| 10 years

BAMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Esomeprazole + Naproxen can be taken orally (tablet).

Age and Dose Restrictions

  • This medicine is meant for adults only.

Contraindications

  • Esomeprazole + Naproxen is contraindicated in patients with known hypersensitivity to any component of the formulation, aspirin, or other NSAIDs.

  • It is also contraindicated in patients with a history of ulcer disease or gastrointestinal bleeding.

Other Medications to Avoid

  • This combination may interact with several medications, including other nonsteroidal anti-inflammatory agents (NSAIDs) (such as ibuprofen), anticoagulants (like warfarin), and medications that affect stomach acidity (such as antacids or H2 blockers like ranitidine).

Overdose and Missed Dose

  • Taking more than the prescribed dose of Esomeprazole + Naproxen may cause symptoms such as stomach pain, nausea, vomiting, drowsiness, or, in severe cases, gastrointestinal bleeding, seizures, difficulty breathing, or loss of consciousness. If you suspect an overdose, seek medical attention immediately.
  • If you miss a dose of Esomeprazole + Naproxen, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Adjusting the timing of the medication may help reduce side effects like stomach upset.

  • Drinking plenty of water can help alleviate some gastrointestinal side effects such as constipation or dry mouth.

Use in Driving and Operating Machinery

  • Esomeprazole + Naproxen may cause dizziness or drowsiness. You are advised to avoid driving or operating heavy machinery if you experience these side effects.

Use in Pregnancy and Lactation

  • Esomeprazole + Naproxen should not be used during pregnancy and lactation unless specifically advised by your doctor due to potential risks to the developing fetus or nursing infant.

Caution in Other Conditions

  • Patients with severe renal or hepatic impairment should exercise caution when taking Esomeprazole + Naproxen.

  • Patients with moderate or severe renal insufficiency should not use the medicine.

Special Dietary and Lifestyle Recommendations

  • Maintain a balanced diet rich in fruits, vegetables, and whole grains which can help manage inflammation associated with conditions like rheumatoid arthritis.

  • Limit consumption of sugary and high-fat foods to help manage weight and reduce potential strain on joints affected by osteoarthritis.

  • Engage in regular physical activity adapted to your condition to enhance joint flexibility and reduce stiffness.

  • Avoid smoking and limit alcohol consumption as these can aggravate inflammation and interfere with the effectiveness of your medication.

Frequently asked questions

No, Esomeprazole + Naproxen is not a steroid. It is a combination of two different medicines: Esomeprazole, which is a proton pump inhibitor, and Naproxen, which is a nonsteroidal anti-inflammatory medicine. It helps in managing pain and inflammation while protecting the stomach from ulcers.

Esomeprazole + Naproxen does not directly affect the menstrual cycle. However, if you experience any changes in your menstrual cycle while taking this medicine, it is advised to consult your doctor.

The suitability of Esomeprazole + Naproxen for vegans or vegetarians depends on the ingredients used in the specific brand of the medicine. It is recommended to check the packaging or consult your pharmacist for this information.

This medication should be used with caution in people with asthma as it may cause bronchospasm (tightening of muscles that line the airways). If you have asthma, discuss this with your doctor before starting this medication.

Alcohol can increase the risk of stomach ulcers and bleeding, a potential side effect of Naproxen. Therefore, it is advisable to avoid or limit alcohol consumption while taking this medication.

One of the possible side effects of Esomeprazole + Naproxen is drowsiness. If you feel excessively drowsy after taking this medication, consult your doctor.

Esomeprazole + Naproxen can cause side effects like dizziness and drowsiness which may impair your ability to drive or operate machinery. It is advised not to drive or operate machinery until you know how this medication affects you.

Terms & Conditions


List of medicines for Esomeprazole + Naproxen

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