Home/Drugs By Ailments /gastroesophageal Reflux Disease (acid Reflux)/ Esomeprazole + Levosulpiride

Esomeprazole + Levosulpiride

Antacid

Uses of Esomeprazole + Levosulpiride

Esomeprazole + Levosulpiride is recommended for managing gastroesophageal reflux disease (GERD) in individuals exhibiting inadequate response to a solitary proton-pump inhibitor (PPI).

Side effects of Esomeprazole + Levosulpiride

  • Headache
  • Diarrhoea
  • Stomach pain 
  • Constipation 
  • Flatulence
  • Nausea
  • Vomiting
  • Benign polyps in the stomach

How Esomeprazole + Levosulpiride works

  • Esomeprazole works as a proton pump inhibitor (PPI), exerting its action on gastric acid (hydrochloric acid - HCl) secretion through specific inhibition of the H+/K+-ATPase enzyme system at the secretory exterior of the gastric parietal cell. As a weak base, esomeprazole undergoes concentration and conversion to its active form (i.e., the achiral sulphenamide) within the highly acidic environment of the secretory canaliculi of the parietal cell. In this locale, it inhibits the enzyme H+K+-ATPase (the acid/proton pump), effectively suppressing both basal and stimulated acid secretion. Through its targeted action on the proton pump, esomeprazole disrupts the final stage of acid production, reducing gastric acidity.
  • Levosulpiride primarily functions as a dopamine D2 antagonist, targeting the muscular D2 receptors activated by dopamine to induce a direct relaxant effect on the gastrointestinal tract. It enhances gut motility by inhibiting D2 receptors in the lower oesophagal sphincter (LES) and stomach. Additionally, levosulpiride serves as an agonist on serotonin 5-HT4 receptors, elevating acetylcholine levels and thereby promoting increased gastrointestinal motility. Its selective antagonist activity on D2 receptors in the central nervous system, particularly in the postrema area of the 4th ventricle, contributes to its antiemetic effects. Acting as a weak inhibitor of 5-HT3 receptors and a moderate agonist at the serotonergic (5-HT4) receptor, levosulpiride exhibits therapeutic efficacy in gastrointestinal disorders, notably reducing nausea and vomiting.

Certified content

Written By

docImg
Amit SharmaClinical Health & Medical Writer| 3 Years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 12 Years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Esomeprazole + Levosulpiride is available for use via the oral route (delayed-release capsules).

Age and Dose Restrictions

  • This combination is meant for adults and children above 14 years of age.

Contraindications

  • Esomeprazole + Levosulpiride is CONTRAINDICATED in patients with known allergies to esomeprazole or levosulpiride and who have Parkinson's disease, severe renal or hepatic insufficiency, epilepsy, porphyrias, breast cancer, or hypokalemia. 

Other Medications To Avoid With This Medicine

  • The concurrent use of medications, including painkillers (aspirin, naproxen), anti-HIV medications (atazanavir), blood-thinning medications (clopidogrel, warfarin, cilostazol), anti-fungal medications (ketoconazole, itraconazole, voriconazole), anti-cancer medications (erlotinib, methotrexate), anti-depressants (citalopram, imipramine, clomipramine, duloxetine), anti-anxiety medications (diazepam), anti-convulsants (phenytoin), gastroprokinetic agents (cisapride), medication for heart problems (digoxin), immunosuppressants (tacrolimus), and anti-tuberculosis medications (rifampicin), alongside Esomeprazole + Levosulpiride is not recommended. Prior consultation with a doctor is essential before considering the use of any prescription or over-the-counter medications to ensure the safety and efficacy of the combined treatment plan.

Overdose and Missed Dose

  • Overdose of this combination can cause confusion, drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache, and dry mouth. Inform your doctor regarding these effects and follow the advice accordingly.
  • If you forget to take a dose of this combination, take it as soon as you remember. However, avoid repeating the dose.

Use In Driving And Operating Machinery

  • This combination may affect your ability to drive or operate heavy machinery. Avoid driving if you feel dizzy after taking this combination.

Use in Pregnancy and Lactation

  • Esomeprazole + Levosulpiride is not recommended during pregnancy and while breastfeeding.

Special Dietary & Lifestyle Recommendation

  • For individuals taking Esomeprazole + Levosulpiride, incorporating specific diet and lifestyle adjustments can complement their gastrointestinal health. Firstly, adopting a mindful eating approach, characterised by smaller and more frequent meals, can ease digestive strain. It's advisable to steer clear of trigger foods, such as spicy or acidic items, and to maintain a balanced diet high in fibre to promote regular bowel movements. Additionally, staying adequately hydrated supports overall digestive function. Considering lifestyle, practising stress management techniques, such as mindfulness or yoga, can positively impact gastrointestinal well-being, as stress can exacerbate digestive issues.

Frequently asked questions

This combination takes effect within a few hours after consumption.

Exercise caution if you are allergic to esomeprazole or levosulpiride and have a history of Parkinson's disease, severe renal or hepatic insufficiency, epilepsy, porphyrias, breast cancer, or hypokalemia.

Do not stop taking this combination without consulting your doctor, even if you feel healthy.

 Consult your doctor before taking this combination if you have kidney or liver issues to ensure its safety and proper dosage.

Terms & Conditions


Available medicines for Esomeprazole + Levosulpiride
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