Esomeprazole + Levosulpiride is a combination medicine used to treat gastro-oesophageal reflux disease (GERD) that does not respond well to a single acid-reducing medicine.
This combination is commonly used for:
• Gastro-oesophageal reflux disease (GERD): Relieves heartburn, acid regurgitation, and chest discomfort caused by stomach acid flowing back into the food pipe.
• Poorly controlled acid reflux: Used when symptoms persist despite treatment with a proton pump inhibitor (PPI) alone.
• Associated digestive discomfort: Helps ease bloating, nausea, and a feeling of fullness linked to slow stomach emptying.
Esomeprazole + Levosulpiride works by reducing stomach acid production and improving the movement of food through the digestive tract.
Esomeprazole is a proton pump inhibitor. It blocks an enzyme in the stomach lining called the proton pump, which is responsible for producing acid. This reduces the amount of acid in the stomach, easing symptoms such as heartburn and acid regurgitation.
Levosulpiride works differently. It blocks dopamine (D2) receptors in the digestive tract, increasing the release of acetylcholine. This improves stomach emptying, strengthens the lower oesophageal sphincter, and reduces the backward flow of stomach acid. It also has a mild effect on nausea and vomiting.
Together, these two medicines reduce acid production while improving digestive movement, providing more complete relief from reflux symptoms.

MBBS

MBBS, DNB (OBGY)
Frequently asked questions
This combination takes effect within a few hours after consumption.
Exercise caution if you are allergic to esomeprazole or levosulpiride and have a history of Parkinson's disease, severe renal or hepatic insufficiency, epilepsy, porphyrias, breast cancer, or hypokalemia.
Do not stop taking this combination without consulting your doctor, even if you feel healthy.
Consult your doctor before taking this combination if you have kidney or liver issues to ensure its safety and proper dosage.
Esomeprazole + Levosulpiride is used to manage acid-related stomach problems, including gastroesophageal reflux disease (GERD). It helps reduce stomach acid, relieve heartburn, acidity, and pain, and improve digestion by supporting normal movement of the stomach and intestines.








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