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Chlorpheniramine + Phenylephrine

Uses of Chlorpheniramine + Phenylephrine

  • Chlorpheniramine + Phenylephrine is used primarily for the relief of symptoms associated with common colds, flu, allergies, and other respiratory conditions. This combination belongs to the group of antihistamine and decongestant medicines.

Side effects of Chlorpheniramine + Phenylephrine

  • Drowsiness and dizziness

  • Dry mouth, nose, and throat

  • Headache

  • Nausea and vomiting

  • Constipation

How Chlorpheniramine + Phenylephrine works

  • Chlorpheniramine + Phenylephrine is a combination antihistamine and decongestant.

  • Chlorpheniramine, the antihistamine, works by blocking the action of histamine, a chemical released in the body during an allergic reaction. Blocking histamine helps to reduce allergy symptoms like itching, sneezing, a runny nose, and watery eyes. It also helps to dry up nasal secretions and improve a post-nasal drip (excess mucus dripping down the back of the throat).

  • Phenylephrine, the decongestant, works by constricting (narrowing) blood vessels in the nasal passages. This reduces swelling and inflammation in the nasal passages. In turn, this can relieve nasal congestion and sinus pressure, making it easier to breathe.

  • When used together, these two components help reduce symptoms associated with conditions like the common cold, flu, allergies and other respiratory conditions.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Chlorpheniramine + Phenylephrine is available for oral use in various forms, including tablets, extended-release tablets, capsules, syrups, and liquids.

  • It is also available as dissolving strips and chewable tablets.

Age and Dose Restrictions

  • This combination is meant for use in adults and children 12 years and above.

Contraindications

  • This combination is contraindicated in patients with known hypersensitivity to any component of the formulation.

  • It is also contraindicated in those currently using or having used monoamine oxidase inhibitors (MAOIs) within the last 14 days.

  • Contraindicated in patients with severe hypertension or coronary artery disease, narrow-angle glaucoma, and urinary retention.

Other Medications to Avoid

  • This combination may interact with MAOIs (such as phenelzine and tranylcypromine), antidepressants (like amitriptyline and fluoxetine), beta-blockers (including atenolol and propranolol), digitalis glycosides (such as digoxin), diuretics (including furosemide and hydrochlorothiazide), antihypertensives (like lisinopril), and CNS depressants (such as diazepam).

Overdose and Missed Dose

  • An overdose might result in severe dizziness, confusion, elevated blood pressure, or an irregular heartbeat. Immediate medical attention is advisable if overdose symptoms occur.

  • If you miss a dose, take it as soon as you remember, unless it is close to the time for your next dose. Do not double the dose to catch up.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage dry mouth or throat caused by this combination, try chewing sugar-free gum or sucking on sugar-free hard candies.

  • If experiencing constipation due to anticholinergic effects of Chlorpheniramine, consider increasing your intake of water and fibre-rich foods.

Use in Driving and Operating Machinery

  • Chlorpheniramine + Phenylephrine may cause drowsiness or dizziness. It is advisable to avoid driving or operating heavy machinery if these symptoms occur.

Use in Pregnancy and Lactation

  • Consult your doctor before using this combination if you are pregnant or breastfeeding. The safety of this combination during pregnancy and lactation has not been firmly established.

Caution in Other Conditions

  • Caution is advised for patients with diabetes as it can affect blood sugar levels.

  • Those suffering from thyroid disorders should consult their doctor due to potential interactions and side effects related to metabolism regulation.

Special Dietary and Lifestyle Recommendations

  • For those using this combination to manage cold and allergy symptoms, increasing fluid intake can help thin nasal secretions and relieve congestion.

  • Avoid smoking or exposure to secondhand smoke as it can worsen respiratory symptoms.

  • Ensure regular washing of hands to prevent the spread of infections that could exacerbate cold symptoms.

  • Consider using a humidifier in your room to ease breathing, especially during nighttime, when symptoms can worsen.

Frequently asked questions

No, it is not a steroid. It is a combination medication that contains an antihistamine (Chlorpheniramine) and a decongestant (Phenylephrine).

It could potentially affect your mood as one of its side effects is restlessness or excitement, especially in children.

There is no evidence to suggest that it affects fertility. However, every individual’s body response varies; so, it is always advisable to consult your doctor if you have any concerns.

There are no specific diet restrictions required while taking it, but taking this combination with food may help reduce the chances of stomach upset.

It should be taken as per the recommended dosage and duration prescribed by your doctor. It is generally used for short-term relief of cold and allergy symptoms and is not intended for long-term daily use.

The time taken for it to start showing its effects can vary depending on the individual’s body response, but it generally starts working within 30 minutes to an hour after consumption.

There is no evidence to suggest that it has a direct effect on the menstrual cycle. However, each individual may react differently to medication and if you notice any changes in your menstrual cycle while taking this combination, consult your doctor.

Terms & Conditions


Chlorpheniramine + Phenylephrine in other salts

CHLORPHENIRAMINE MALEATECETIRIZINE + PARACETAMOL + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDECHLORPHENIRAMINE MALEATE + PARACETAMOL + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PHENYLEPHRINE HYDROCHLORIDECHLORPHENIRAMINE + DEXTROMETHORPHAN + PHENYLEPHRINECPM + DEXTROMETHORPHAN + PHENYLEPHRINECAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINE HYDROCHLORIDECAFFEINE + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEBECLOMETHASONE DIPROPIONATE + LIDOCAINE / LIGNOCAINE + PHENYLEPHRINECALCIUM DOBESILATE + HYDROCORTISONE + LIDOCAINE / LIGNOCAINE + PHENYLEPHRINE + TROXERUTIN + ZINC OXIDEPHENYLEPHRINECETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDECHLORPHENIRAMINE + NAPHAZOLINECARBOXY METHYL CELLULOSE + NAPHAZOLINE + PHENYLEPHRINENAPHAZOLINE + PHENYLEPHRINECHLORPHENIRAMINE + CODEINEAMBROXOL + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORBUTOL + PHENYLEPHRINE + TROPICAMIDECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEAMBROXOL + CHLORPHENIRAMINE + DEXTROMETHORPHAN + MENTHOL + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + CODEINEAMMONIUM CHLORIDE + CHLORPHENIRAMINE MALEATE + SODIUM CITRATEBROMHEXINE + GUAIFENESIN + PHENYLEPHRINEBROMHEXINE + PHENYLEPHRINE + SALBUTAMOLBROMHEXINE + CHLORPHENIRAMINE MALEATE + GUAIFENESINBENZALKONIUM CHLORIDE + PHENYLEPHRINE + TROPICAMIDEPHENYLEPHRINE + TROPICAMIDECAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + CAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + MENTHOLCHLORPHENIRAMINE MALEATE + DEXTROMETHORPHANAMBROXOL + CHLORPHENIRAMINE + GUAIFENESIN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATELEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PHENYLEPHRINE HYDROCHLORIDEBROMHEXINE + CHLORPHENIRAMINE + DEXTROMETHORPHANCHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEAMBROXOL + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + PHENYLEPHRINECHLORPHENIRAMINE + LEVODROPROPIZINECHLORPHENIRAMINE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINECETIRIZINE + DEXTROMETHORPHAN + PHENYLEPHRINEBROMHEXINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + GUAIFENESIN + PHENYLEPHRINEDEXTROMETHORPHAN + PHENYLEPHRINE + TRIPROLIDINECHLORPHENIRAMINE + DIETHYLCARBAMAZINEAMBROXOL + CHLORPHENIRAMINE + GUAIFENESIN + MENTHOL + PHENYLEPHRINELEVOCETIRIZINE + PHENYLEPHRINEAMBROXOL + GUAIFENESIN + LEVOCETIRIZINE + PHENYLEPHRINEBROMHEXINE + DEXTROMETHORPHAN + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + PHENYLEPHRINE HYDROCHLORIDECHLORPHENIRAMINE + DEXTROMETHORPHAN + GUAIFENESINDEXCHLORPHENIRAMINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLPROPANOLAMINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PHENYLPROPANOLAMINECETIRIZINE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINE HYDROCHLORIDECETIRIZINE + DEXTROMETHORPHAN + PHENYLEPHRINE HYDROCHLORIDECAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEAMBROXOL + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + MENTHOL + PHENYLEPHRINEAMBROXOL + CETIRIZINE + GUAIFENESIN + PHENYLEPHRINEAMMONIUM CHLORIDE + CHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + GUAIFENESINBROMHEXINE + CHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + GUAIFENESINCAFFEINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECETIRIZINE + PHENYLEPHRINECHLORPHENIRAMINECAFFEINE + DIPHENHYDRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECAFFEINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEFEXOFENADINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECAFFEINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHENBROMHEXINE + CPM + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DIETHYLCARBAMAZINEBROMHEXINE + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEAMBROXOL + LEVOCETIRIZINE + PHENYLEPHRINECAFFEINE + CETIRIZINE + NIMESULIDE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECAFFEINE + CETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDELEVOCETIRIZINE + NIMESULIDE + PHENYLEPHRINEAMBROXOL + CETIRIZINE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECAFFEINE + CETIRIZINE + NIMESULIDE + PHENYLEPHRINE
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