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Pregabalin + Nortriptyline + Methylcobalamin

Drugs For Peripheral Neuropathy

Uses of Pregabalin + Nortriptyline + Methylcobalamin

Pregabalin + Nortriptyline + Methylcobalamin is a triple combination used to treat nerve pain (neuropathic pain) caused by conditions such as diabetes, shingles, and nerve damage.

This combination is commonly used for:

  • Diabetic peripheral neuropathy: Relieves pain, burning, tingling, and numbness in the hands and feet caused by nerve damage from long-standing diabetes.
  • Post-herpetic neuralgia: Manages persistent nerve pain that continues after the skin rash of shingles (herpes zoster) has healed.
  • Fibromyalgia: Helps manage widespread musculoskeletal pain and tenderness associated with this chronic condition.
  • Generalised neuropathic pain: Used for other conditions involving chronic nerve-related pain, helping reduce pain intensity and associated symptoms.
  • Vitamin B12-related nerve symptoms: Supports nerve health in patients whose nerve symptoms may be associated with low Vitamin B12 levels.

This triple combination addresses pain relief, neuropathic symptom management, and nerve health support together, and may also help improve sleep quality and mobility with regular, prescribed use.

Side effects of Pregabalin + Nortriptyline + Methylcobalamin

The side effects of Pregabalin + Nortriptyline + Methylcobalamin are:

  • Constipation
  • Weight gain
  • Orthostatic
  • Hypotension
  • Increased heart rate
  • Dizziness
  • Sleepiness
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Difficulty in urination
  • Uncoordinated body movements

How Pregabalin + Nortriptyline + Methylcobalamin works

  • Pregabalin + Nortriptyline + Methylcobalamin works through three complementary mechanisms that together provide more comprehensive relief from neuropathic pain than any single medicine alone.
  • Pregabalin binds to calcium channels (alpha-2-delta subunits) on nerve cells. This reduces the release of neurotransmitters involved in transmitting pain signals, calming overactive nerve activity and decreasing the intensity of pain messages reaching the brain.
  • Nortriptyline is a tricyclic antidepressant that works by blocking the reuptake of serotonin and norepinephrine in the brain. Higher levels of these neurotransmitters strengthen the body's own pain-modulating pathways, providing additional pain relief and may help improve mood in some patients, which is often affected by chronic pain.
  • Methylcobalamin is the active, neurologically available form of Vitamin B12. It supports nerve health and myelin maintenance, helping maintain normal nerve function, particularly in individuals with Vitamin B12 deficiency.
  • Together, these three components reduce pain signal transmission, enhance the brain's natural pain control, and support nerve health.

Certified content

Written By

docImg
Dr. Sachin SinghMedical Team Lead & Reviewer| 7 years

MBBS

Reviewed By

Dr. Mandeep Chadha
Dr. Mandeep ChadhaLead Medical Content Reviewer| 12 years

MBBS, DNB (OBGY)

Expert Advice

Dosage Forms Available

  • Pregabalin + Nortriptyline + Methylcobalamin is taken orally (tablet).

Age and Dose Restrictions

  • This combination can be used for adults only. 

Contraindications

  • This medicine is contraindicated in patients with known allergies to methylcobalamin,  nortriptyline or pregabalin.

Other Medications to Avoid

  • Avoid taking other antidepressants, antihypertensives, antidiabetics (pioglitazone, rosiglitazone), any narcotic pain medicine (such as oxycodone), tranquillisers or medicines for anxiety (such as lorazepam), muscle relaxants, antiarrhythmic (quinidine), sedatives, selective serotonin reuptake inhibitors (SSRIs) (citalopram (Celexa), escitalopram) and antihistamines. The concomitant use may reduce the effectiveness of Methylcobalamin + Nortriptyline + Pregabalin.

Overdose and Missed Dose

  • An overdose of this combination requires immediate medical attention from your doctor or the nearest hospital. Symptoms of an overdose may include drowsiness, confusion, agitation, restlessness, rapid heartbeat, low blood pressure, seizures, or difficulty breathing. Strict adherence to the prescribed dose is essential.
  • If you miss a dose of this combination, take it as soon as you remember. If it is close to the time for your next dose, skip the missed one and resume your regular dosing schedule. Do not double the dose to make up for a missed one.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.

Use in Driving and Operating Machinery

  • This combination may cause dizziness and drowsiness and impair your ability to drive or operate machinery.

Use in Pregnancy and Lactation

  • This combination is not recommended during pregnancy. Caution is advised before using this combination during breastfeeding.

Caution in Other Conditions

  • Caution is advised in older adults and in patients with angioedema, kidney and heart failure, a bleeding problem or a low blood platelet count, diabetes, thyroid gland, and angle-closure glaucoma. 

Special Dietary and Lifestyle Recommendations

  • Keep your blood sugar levels within the target range for preventing and managing neuropathy.
  • Alcohol can cause further damage to nerves, so limit your alcohol consumption or avoid it.
  • Check your feet daily for wounds, cuts, or blisters, as neuropathy can reduce sensation and increase the risk of foot problems.
  • Follow your prescribed medication regimen consistently.  
  • Avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Nortriptyline may make your skin sensitive to sunlight.

Disease/Condition Glossary

  • Neuropathic pain is a type of chronic pain that occurs due to nerve damage or dysfunction. Unlike other types of pain, it is often described as burning, shooting or electric-shock-like and usually occurs in the hands, feet, or along the spine. This pain can occur when you suffer from conditions such as diabetes, shingles, tests, or nerve injury. It can persist even after the initial injury has healed, and may be associated with numbness or tingling. It is managed with medications such as pregabalin, gabapentin, or antidepressants, and in more serious cases, physiotherapy and nerve blocks are used.

Frequently asked questions

No, using this medicine during pregnancy may not be safe. Although there is a lack of information in human research, there is evidence from animal studies that this is harmful to a fetus. Your doctor will consider the risks and benefits before a prescription is given. Please consult your physician.

Within 2 to 4 hours, you must experience the benefit of this medicine.

No, it's likely unsafe to take this medication during breastfeeding. According to human data, the medicine may enter the breast milk and damage the unborn baby.

It is not recommended to use any antidepressants (like duloxetine, sertraline, and escitalopram), pain relievers (like codeine, hydrocodone, morphine, oxycodone, tramadol, and acetaminophen), and anti-seizure drugs (like topiramate), anti-anxiety medications (like alprazolam), sedative-hypnotic medications (like zolpidem), antihistamine medications (like diphenhydramine, cetirizine), muscle relaxant medications (like cyclobenzaprine), antiemetic medications (like ondansetron), and herbal medications to treat depression (like St. John's wort). Before using any prescription or over-the-counter medications, you must consult with your doctor.

Do not use Pregabalin + Nortriptyline + Methylcobalamin if you have an allergic reaction (hypersensitivity) to any of its components. Do not take this medicine if you consume alcohol. Due to a possible interaction, this medicine may increase the chance of serious adverse effects. We recommend that you consult a doctor as soon as possible.

No, please do not stop taking this medication without first consulting your doctor. There is a chance that symptoms may return if Pregabalin + Nortriptyline + Methylcobalamin is suddenly stopped.

Yes, this medication may lead to weight gain because it stimulates appetite. However, continuous movement and a diet that balances low-calorie foods with balanced meals may help you maintain your weight. If you continue to have issues maintaining a healthy weight, you must consult with a doctor.

No, the use of Pregabalin + Nortriptyline + Methylcobalamin will not lead to the development of any habitual actions. There have been no reports that withdrawal symptoms may appear when it is stopped. People in this situation can develop a psychological dependence on the medication if they continue to use it.

Yes, taking Pregabalin + Nortriptyline + Methylcobalamin frequently can cause dry mouth. If this side effect continues to disturb you, make an appointment with your doctor.

No, avoid consuming alcohol while taking Pregabalin + Nortriptyline + Methylcobalamin because it could increase dizziness and drowsiness.

No, this medication is unlikely to affect fertility in either men or women. However, there is currently insufficient evidence to justify any clear conclusion. Consult your doctor for the most accurate information.

Yes, Pregabalin + Nortriptyline + Methylcobalamin should be used with precaution, specifically if you have a history of kidney disorders or problems. Some patients may need a dosage modification. If you have any problems, you should consult your doctor.

Yes, it's likely safe to take this medication in liver disease patients. No modification to the dosage is recommended. If you have any problems, you should consult your doctor.

Yes, this medication may cause dizziness. While using this medication, it is recommended that you should not drive or operate heavy machinery. It is suggested to relax until you feel better if you are experiencing sleep or dizziness.

Pregabalin + Nortriptyline + Methylcobalamin is used to manage nerve-related pain. It helps relieve pain caused by diabetic neuropathy, nerve injuries, post-herpetic neuralgia, and fibromyalgia. This combination helps reduce abnormal nerve pain signals and improve nerve function, thereby reducing burning, tingling, and shooting pain sensations.

Terms & Conditions


List of medicines for Pregabalin + Nortriptyline + Methylcobalamin

Pregaba Mnt Tablet 10
Pregaba Mnt Tablet 10
Torrent Pharmaceuticals Ltd.
Pack of 10 Units
₹169.13
MRP ₹206.25
18% OFF
Pregabanyl Ntm Tablet 10
Pregabanyl Ntm Tablet 10
Leeford Healthcare
Pack of 10 Units
₹53.44
MRP ₹66.8
20% OFF
Pregabid Mnt Tablet 10
Pregabid Mnt Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹135
MRP ₹168.75
20% OFF
Prelin Mnt Tablet 10
Prelin Mnt Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
₹216
MRP ₹240
10% OFF
Dubinor Tablet 10
Dubinor Tablet 10
Integrace Health
Pack of 10 Units
₹158.36
MRP ₹193.12
18% OFF
Neugaba Mn Tablet Pr 10
Neugaba Mn Tablet Pr 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹168.75
MRP ₹210.94
20% OFF
Resner Plus Tablet 10
Resner Plus Tablet 10
Lupin Ltd
Pack of 10 Units
₹135.01
MRP ₹160.73
16% OFF
Nortipan M Tablet 10
Nortipan M Tablet 10
Medley Pharmaceuticals
Pack of 10 Units
₹135
MRP ₹168.75
20% OFF

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Telephone:09240250346

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