Home/Drugs By Ailments / L Methyl Folate + Methylcobalamin + Pyridoxal 5 Phosphate

L Methyl Folate + Methylcobalamin + Pyridoxal 5 Phosphate


Uses of L Methyl Folate + Methylcobalamin + Pyridoxal 5 Phosphate

  • L Methyl Folate + Methylcobalamin + Pyridoxal 5 Phosphate is mainly indicated in patients to protect nerve cell health in diabetic cells neuropathy.
  • This combination is also used to treat endothelial dysfunction and hyperhomocysteinemia with lower extremity ulcers.
  • It is also used to promote general well-being.

Side effects of L Methyl Folate + Methylcobalamin + Pyridoxal 5 Phosphate

  • Nausea
  • Stomach upset
  • Diarrhoea 
  • Abdominal pain
  • Itching
  • Loss of appetite

How L Methyl Folate + Methylcobalamin + Pyridoxal 5 Phosphate works

  • L Methyl Folate is responsible for neurotransmitter synthesis and plays an essential role in the critical enzymatic reactions of the body. It reduces the levels of excess homocysteine and confers cardiovascular health and nervous system function.
  • Methylcobalamin plays a crucial role in nerve function and repair. It helps form and maintain myelin sheath, which is essential for healthy nerve function.
  • Pyridoxal 5-phosphate plays an essential role in synthesising RNA and DNA, helps maintain the sodium-potassium balance, promotes red blood cell formation, and provides nutrition to nerve cells. 

Certified content

Written By

Amit SharmaClinical Health & Medical Writer| 3 Years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 12 Years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • L Methyl Folate + Methylcobalamin + Pyridoxal 5 Phosphate can be taken orally (available as tablet, capsule, and syrup).

Age And Dose Restrictions

  • This combination is meant to be used for adults only. It is not recommended for children.


  • It is contraindicated in patients with a history of hypersensitivity to L Methyl Folate or Methylcobalamin or Pyridoxal 5 Phosphate.

Medications To Avoid With This Drug 

  • Avoid taking anticonvulsants (carbamazepine), medications for Parkinson’s disease (levodopa), antibiotics (amoxicillin), bile acid sequestrants (cholestyramine), anti-diabetic medications (metformin), anticoagulants (warfarin), and antimetabolites (methotrexate). These medications may alter the safety and effectiveness of this combination.

Overdose And Missed Dose

  • If an overdose occurs and leads to severe side effects or worsening of any of the symptoms, it needs to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
  • If you miss a dose of this combination, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.

Use In Driving And Operating Machinery

  • It is unlikely to impair the mental alertness or coordination required while driving.

Use In Pregnancy And Lactation

  • Caution is advised during pregnancy and breastfeeding.

Caution In Other Conditions

  • Caution is advised in older adults and in patients having liver or kidney disease, coronary artery disease, and malabsorption syndrome.

Special Dietary And Lifestyle Recommendation

  • Keep your blood sugar levels within the target range for preventing and managing neuropathy.
  • Limit your sugary and processed foods intake, as they can spike your blood sugar levels.
  • Alcohol can cause further damage to nerves, so limit your alcohol consumption or avoid it.
  • Check your feet daily for wounds, cuts, or blisters, as neuropathy can reduce sensation and increase the risk of foot problems. 

Frequently asked questions

This combination is not a painkiller. It is used to manage neuropathic pain associated with diabetic peripheral neuropathy.

Abruptly stopping this medication may lead to withdrawal symptoms such as rebound neuropathic pain, dizziness, headache, or anxiety. 

No, this combination is not a sleeping medication. 

Caution should be advised in patients with liver issues while giving this combination. 

The dosage and frequency is usually determined based on the patient's medical condition and the severity of disease.

This combination can have potential side effects on the heart, and individuals with pre-existing heart conditions should use it with caution and under the supervision of a doctor. 

No, this combination is not a habit-forming medication.

Terms & Conditions

Sorry we currently were not able to find medicines related to L METHYL FOLATE + METHYLCOBALAMIN + PYRIDOXAL 5 PHOSPHATE.


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