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Ondansetron

Antiemetic

Uses of Ondansetron

  • Ondansetron is mainly used to manage nausea and vomiting. It belongs to a class of medications known as serotonin 5-HT3 receptor antagonists.
  • In addition to its primary purpose, it can also be used to prevent nausea and vomiting in patient undergoing chemotherapy, radiation therapy, or post-surgery, effectively addressing these issues.

Side effects of Ondansetron

  • Constipation
  • Diarrhoea
  • Fatigue
  • Dizziness
  • Headache

How Ondansetron works

  • Ondansetron functions by blocking specific serotonin (5-HT3) receptors located in the brain and gastrointestinal tract, particularly in the chemoreceptor trigger zone. This blockade helps alleviate the feeling of nausea and prevents vomiting.

Certified content

Written By

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Amit SharmaMedical Content Writer| 4 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Medical Content Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Ondansetron is available for use via the oral route (tablet, dissolving tablet, oral solution (liquid and drops)).

Age and Dose Restrictions

  • This medicine is meant for adults and children above four years of age.

Contraindications

  • The medication is not recommended in patients with a known allergy to Ondansetron and severe liver and kidney disease.

Other Medications to Avoid

  • Ondansetron may interact with certain medications, including painkillers such as acetaminophen, tramadol, and ibuprofen. It may also interact with anti-anxiety medications like pregabalin and lorazepam, as well as antiparkinson medicine such as apomorphine. You must inform your doctor about all the medications you are taking to avoid potential adverse effects.

Overdose and Missed Dose

  • An overdose of this medication may cause symptoms like constipation, sudden vision loss, or an irregular heartbeat. If you observe these symptoms, inform your doctor and follow the advice accordingly.
  • If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

Use in Driving and Operating Machinery

  • This medication can cause dizziness; hence, avoid heavy activities. If this medicine is given to a child, keep them under supervision.

Use in Pregnancy and Lactation

  • Ondansetron is safe for use in pregnancy and breastfeeding.

Caution in Other Conditions

  • Patients with a history of hypokalemia (low potassium) should be cautious.

Special Dietary and Lifestyle Recommendations

  • A healthy diet plays a crucial role in maintaining overall well-being and reducing the chances of nausea and vomiting. 
  • Consuming a balanced diet that includes plenty of fruits, vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils, and low-fat dairy products can help support good health.
  • Greasy or oily foods should be avoided, as they can trigger nausea and vomiting. Opting for cool foods instead of hot and spicy meals may also help in managing symptoms.
  • To replenish fluids lost due to vomiting, it is beneficial to include clear broths, non-fat yogurt, fruit juice, sherbet, and sports drinks in the diet. These options help restore hydration and essential nutrients.

Frequently asked questions

Ondansetron usually starts working within 30 minutes to 2 hours after administration, depending on the form (tablet, injection, or oral solution). Its effect lasts for about 4 to 8 hours.

Avoid taking Ondansetron if you have a history of severe liver disease or allergic reactions to similar medications. 

You should only stop taking Ondansetron after consulting your doctor, especially if it was prescribed for ongoing nausea and vomiting, as stopping it abruptly may lead to symptom recurrence.

Patients with severe liver disease should use Ondansetron cautiously, as dosage adjustments may be required. It is generally safe for kidney patients, but a doctor's advice is recommended for proper monitoring.

There is no strong evidence suggesting that Ondansetron affects fertility in men or women. However, consult your doctor if you are trying to conceive or are pregnant.

Terms & Conditions


List of Medicines for Ondansetron

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