Metronidazole, classified as a nitroimidazole, exhibits antibacterial efficacy within anaerobic environments, particularly against most obligate anaerobes. It undergoes reduction following passive diffusion into the organism and subsequent activation in the cytoplasm of susceptible anaerobic bacteria. This reduction process involves intracellular electron transport proteins like ferredoxin, electron transfer to the nitro group of metronidazole, and the generation of a transient nitroso free radical. The reduced form of metronidazole and resultant free radicals can interact with DNA, inhibiting DNA synthesis and promoting DNA degradation, ultimately leading to bacterial death.
B. Pharm
B. Pharm, MSc.
Frequently asked questions
It starts showing its effects within a few hours after consumption.
Avoid using this medication in the presence of known hypersensitivity or allergic reactions to Metronidazole. Refrain from taking this medication if alcohol is consumed, as a potential interaction may elevate the risk of severe adverse effects. It is advisable to seek medical attention in such circumstances promptly.
Do not stop taking this medication without consulting your doctor, even if you feel healthy.
Consult your doctor before taking this medication if you have kidney or liver issues to ensure its safety and proper dosage.
This medication does not affect contraception.
Metronidazole in other salts
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