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Ofloxacin + Metronidazole

Antibiotic

Uses of Ofloxacin + Metronidazole

Ofloxacin + Metronidazole is a combination medicine used for selected gastrointestinal infections caused by susceptible bacteria, anaerobic organisms, or protozoa.
This combination is commonly used for:
• Infectious diarrhoea: May be prescribed for acute diarrhoea caused by susceptible bacteria or protozoa when antimicrobial treatment is needed.
• Dysentery: Treats selected cases of bacterial or amoebic dysentery, as directed by a doctor.
• Mixed gastrointestinal infections: Targets susceptible aerobic bacteria, anaerobic bacteria, and protozoa when more than one type of organism is involved.
• Amoebiasis with suspected bacterial co-infection: May be used when both amoebic and bacterial causes require treatment.
• Giardiasis with suspected bacterial co-infection: May be used in selected mixed infections under medical supervision.
• Other confirmed mixed infections: Used only when a clinician determines that both components are appropriate for the likely or confirmed organisms.

Side effects of Ofloxacin + Metronidazole

  • Low blood sugar 
  • Disturbance in attention
  • Disorientation
  • Agitation
  • Nervousness 

How Ofloxacin + Metronidazole works

Ofloxacin + Metronidazole works through two complementary actions against susceptible bacteria, anaerobic organisms, and protozoa in selected infections.
Ofloxacin is a fluoroquinolone antibiotic. It blocks bacterial DNA gyrase and topoisomerase IV, enzymes that susceptible bacteria need to copy and repair their DNA. This stops bacterial multiplication.
Metronidazole is a nitroimidazole antibacterial and antiprotozoal agent. Inside anaerobic bacteria or protozoa, it forms active compounds that damage DNA and prevent replication.
Together, these medicines provide antibacterial and antiprotozoal activity when a mixed infection has been diagnosed or is strongly suspected.

Certified content

Written By

docImg
Dr. Sachin SinghMedical Team Lead & Reviewer| 7 years

MBBS

Reviewed By

Dr. Mandeep Chadha
Dr. Mandeep ChadhaLead Medical Content Reviewer| 12 years

MBBS, DNB (OBGY)

Expert Advice

Dosage Forms Available 

  • Ofloxacin + Metronidazole can be taken orally (suspension).

Age And Dose Restrictions

  • It can be used by adults above 18 years of age.

Contraindications 

  • It is contraindicated in patients with a history of hypersensitivity to ofloxacin or metronidazole.

Other Medications To Avoid With This Medicine 

  • Avoid taking nutritional supplements, anti-inflammatory medications (theophylline, fenbufen), uricosurics (probenecid), antiarrhythmics (quinidine), antidepressants (sertraline) and anticoagulants (warfarin) with Ofloxacin + Metronidazole. These medications may alter the safety and effectiveness of Ofloxacin + Metronidazole.

Overdose And Missed Dose

  • Taking more than the prescribed amount may cause symptoms such as nausea, vomiting, dizziness, headache, confusion, or tingling in the hands and feet. In rare cases, seizures may occur. If you accidentally take an overdose, stop using the medicine and seek medical help immediately. Strict adherence to the prescribed dose is essential.
  • If you miss a dose of Ofloxacin + Metronidazole, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not take two doses together to make up for a missed dose. It is important to complete the full course of antibiotics as prescribed to ensure the infection is fully treated.

Management Of Side Effects

  • The side effects resolve after the combination is discontinued. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

  • It is not recommended to drive, operate machinery, or do other activities that require mental alertness or coordination after taking this medicine. 

Use In Pregnancy And Lactation

  • Caution is advised in pregnant and breastfeeding women.

Caution In Other Conditions

  • Caution should be taken in older patients especially with kidney dysfunction, liver impairment, heart problems, and patients on corticosteroids.

Special Dietary And Lifestyle Recommendation

  • Make sure you drink plenty of water or other fluids every day.
  • Exercise regularly for the best physical and mental health.
  • Take a balanced diet to nourish the body and the brain.
  • Maintain proper hygiene to avoid bacterial infections.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, such as grapefruit and grapefruit juice, as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.
  • Antibiotics can alter the useful bacteria in the stomach, which can cause indigestion. Therefore, you are advised to take foods rich in probiotics, such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.

Frequently asked questions

Ofloxacin + Metronidazole is used to treat bacterial and parasitic infections in the gastrointestinal and genitourinary tracts. Ofloxacin targets bacterial infections, while Metronidazole is effective against anaerobic bacteria and parasites. This combination is commonly prescribed for conditions like diarrhea, dysentery, bacterial vaginosis, pelvic infections, and certain urinary tract infections, helping clear infections and relieve symptoms.

No, it is not an antifungal medication. It is an antibiotic and antiprotozoal combination that works against bacterial and parasitic infections.

Yes, this combination is good for bacterial infections. 

This combination takes more than 2-4 days to show the complete effect. The immediate effect of the medicine is seen within 1-2 hours. However, the response varies from one individual to another individual.

Yes, the use of Ofloxacin + Metronidazole can cause diarrhoea as a side effect due to its impact on gut bacteria.

Ofloxacin + Metronidazole is  not classified as a very strong antibiotic, but it’s effective against certain infections.  

It is generally safe to take Ofloxacin + Metronidazole for 7-10 days, as prescribed by a doctor.  The duration of use depends on the specific condition and your doctor’s recommendation.

Individuals with a history of allergic reactions to quinolones or nitroimidazoles should avoid using Ofloxacin + Metronidazole. People with irregular heart rhythms or certain allergies should avoid it.

It typically takes a few days to a week for Ofloxacin + Metronidazole to effectively clear an infection, depending on its severity.

Terms & Conditions


List of medicines for Ofloxacin + Metronidazole

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Telephone:09240250346

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