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Metronidazole + Norfloxacin

Uses of Metronidazole + Norfloxacin

  • The primary use of Metronidazole + Norfloxacin is to manage a broad range of bacterial and parasitic infections. This combination medication belongs to the class of antibiotics.

  • Furthermore, they are used in managing bacterial diarrhoea and dysentery, intestinal amebiasis, giardiasis, bacterial vaginosis, anaerobic bacterial infections, and urinary tract infections among others.

Side effects of Metronidazole + Norfloxacin

  • Nausea

  • Vomiting

  • Metallic taste

  • Diarrhoea

  • Headache

How Metronidazole + Norfloxacin works

  • Metronidazole, a nitroimidazole antimicrobial, infiltrates bacterial cells and damages their DNA. This blocks the production of nucleic acids in these cells, thus preventing their growth. Metronidazole is particularly effective against anaerobic bacteria and certain parasites.

  • Norfloxacin, part of the fluoroquinolone class of antibiotics, works by impeding two critical bacterial enzymes: DNA gyrase and topoisomerase IV. These enzymes play key roles in the replication and repair of bacterial DNA. By hindering these enzymes, Norfloxacin stalls bacterial cell division and growth. The combination of Metronidazole and Norfloxacin works in synergy to provide wide-ranging antimicrobial coverage against diverse bacterial and parasitic infections that neither could manage on its own.

Certified content

Written By

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Dr. Osama AhmedDental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Reviewed By

Ashmita Borgohain
Ashmita BorgohainMedical Content Writer & Editor| 12 years

MSc (Applied Genetics)

Expert Advice

Dosage Forms Available

  • Metronidazole + Norfloxacin can be taken orally (tablets, capsules, and suspension).

Age and Dose Restrictions

  • This medicine is intended for use by adults and children over the age of 12 years.

Contraindications

  • The medicine is contraindicated in patients with known hypersensitivity to either Metronidazole or Norfloxacin. It should not be used in patients with severe hepatic impairment. The combination medication should not be given to patients who have taken disulfiram within the last two weeks.

Other Medications to Avoid

  • Metronidazole + Norfloxacin may interact with class Ia/III antiarrhythmics (such as quinidine and amiodarone), anticoagulants (like warfarin), and oral hypoglycemics (like glibenclamide).

Overdose and Missed Dose

  • An overdose of Metronidazole + Norfloxacin can lead to symptoms such as nausea, vomiting, dizziness, tremors, and seizures. If you suspect an overdose, seek immediate medical help.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular schedule.

Management of Side Effects

Most side effects are temporary, generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For gastrointestinal issues such as nausea or vomiting, it may help to take Metronidazole + Norfloxacin with food.

  • Drinking plenty of water can help manage side effects such as thirst or dry mouth.

  • Resting and avoiding strenuous activity may alleviate fatigue.

Use in Driving and Operating Machinery

  • Metronidazole + Norfloxacin may cause dizziness or sleepiness. If you experience these symptoms, avoid driving or operating machinery.

Use in Pregnancy and Lactation

  • Metronidazole + Norfloxacin are not recommended for use during pregnancy, especially during the first trimester, or while breastfeeding. Always consult your doctor before using this medicine during these periods.

Caution in Other Conditions

  • Patients with kidney disease or liver disease should use Metronidazole + Norfloxacin with caution, as dosage adjustments may be necessary.

  • Similarly, those with neurological conditions, including seizures or peripheral neuropathy should also exercise caution while on this medication.

Special Dietary and Lifestyle Recommendations

  • Regular handwashing and hygiene practices can help prevent the spread of infections for which Metronidazole + Norfloxacin are prescribed.

  • Avoid excessive exposure to the sun to prevent photosensitivity reactions related to Norfloxacin.

Frequently asked questions

Every person's reaction to a medicine may vary, and if you observe any unusual mood swings or changes while taking this medication, you should consult your doctor.

Weight gain is not typically associated with the use of Metronidazole + Norfloxacin. However, if you do notice any unexpected weight changes while taking this medicine, you should consult your doctor.

Metronidazole + Norfloxacin are antibiotic medication and there is no evidence to suggest that they poses a risk of addiction.

If you have a history of allergies to Metronidazole, Norfloxacin, or other similar medications, you should not take this combination without discussing it with your doctor.

While there are natural remedies that may help support a healthy immune system, they should not be used as a substitute for prescribed antibiotic treatment such as Metronidazole + Norfloxacin. Always consult your doctor for appropriate treatment.

Metronidazole has a half-life of approximately 8 hours and Norfloxacin has a half-life of about 3–4 hours. This means that half of the medicine leaves the body within these time frames.

Metronidazole + Norfloxacin might cause insomnia in some individuals. If you experience difficulty falling asleep or maintaining sleep, consult your doctor.

Terms & Conditions


Available medicines for METRONIDAZOLE + NORFLOXACIN
Nor Metrogyl 400/500 MG Tablet 10
Nor Metrogyl 400/500 MG Tablet 10
Lekar Pharma Ltd
Pack of 10 Units
₹13.47
MRP ₹16.43
18.00% OFF
Bacigyl N 100/100 MG Suspension 30 ML
Bacigyl N 100/100 MG Suspension 30 ML
Aristo Pharmaceuticals Pvt.ltd
Pack of 30 ML
₹13.12
MRP ₹16.00
18.00% OFF
Bacigyl N 100/100 MG Suspension 60 ML
Bacigyl N 100/100 MG Suspension 60 ML
Aristo Pharmaceuticals Pvt.ltd
Pack of 60 ML
₹21.61
MRP ₹26.35
18.00% OFF
Nor Metrogyl 100/100 MG Suspension 30 ML
Nor Metrogyl 100/100 MG Suspension 30 ML
Lekar Pharma Ltd
Pack of 30 ML
₹12.45
MRP ₹15.18
18.00% OFF
Powergyl Oz 100/100 MG Tablet 10
Powergyl Oz 100/100 MG Tablet 10
Cipla Ltd.
Pack of 10 Units
₹52.89
MRP ₹106.00
50.10% OFF
Power Stop 100/200 MG Syrup 30 ML
Power Stop 100/200 MG Syrup 30 ML
Psychotropics India Ltd
Pack of 30 ML
₹36.90
MRP ₹45.00
18.00% OFF
Nor Metrogyl 100/100 MG Syrup 60 ML
Nor Metrogyl 100/100 MG Syrup 60 ML
Lekar Pharma Ltd
Pack of 60 ML
₹29.66
MRP ₹36.17
18.00% OFF

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