Metformin + Teneligliptin
AntidiabeticUses of Metformin + Teneligliptin
Metformin + Teneligliptin is used to manage blood sugar levels in adults with type 2 diabetes mellitus. Metformin reduces the amount of sugar produced by the liver, while Teneligliptin helps the body release more insulin after meals.
This combination is commonly used for:
• Type 2 diabetes mellitus: Helps control high blood sugar levels when diet and exercise alone are not enough.
• Blood sugar management alongside other diabetes medicines: Used in combination with other treatments when a single medicine does not adequately control blood sugar.
• Long-term glycaemic control: Supports sustained control of blood sugar levels to help reduce the risk of diabetes-related complications.
Side effects of Metformin + Teneligliptin
- Hypoglycemia
- Constipation
- Fatigue
- Headache
- Dizziness
- Bloating
- Abdominal discomfort
- Nausea
- Vomiting
- Loss of appetite
How Metformin + Teneligliptin works
Metformin + Teneligliptin works through two different actions that together help control blood sugar levels.
Metformin belongs to a class of medicines called biguanides. It works by reducing the amount of glucose produced by the liver and improving the body's sensitivity to insulin, helping muscles use glucose more effectively.
Teneligliptin belongs to a class of medicines called DPP-4 inhibitors. It works by blocking an enzyme called dipeptidyl peptidase-4, which normally breaks down hormones that stimulate insulin release after meals. By blocking this enzyme, Teneligliptin increases insulin release and decreases glucagon secretion, thereby reducing glucose production by the liver, particularly after eating.
Together, Metformin and Teneligliptin work through complementary pathways to lower blood sugar more effectively than either medicine alone.
Certified content
Written By
MBBS
Reviewed By
MBBS, DNB (OBGY)
Expert Advice
Dosage Forms Available
- Metformin and Teneligliptin can be combined orally (tablet).
Age And Dose Restrictions
- This combination is not intended to be used by children.
Contraindications
- This combination is contraindicated in patients with a history of hypersensitivity to Metformin and Teneligliptin.
Medications To Avoid With This Drug
- Avoid taking antifungals (ketoconazole), antidepressants, antihypertensives, steroids, diuretics, thyroid medications, corticosteroids, phenothiazines, estrogens, oral contraceptives, anticonvulsants (phenytoin), and antiepileptics (ranolazine). These medications may alter the safety and effectiveness of Metformin and Teneligliptin.
Overdose And Missed Dose
- Taking more than the prescribed dose of Metformin + Teneligliptin may cause nausea, vomiting, diarrhoea, dizziness, or, in severe cases, lactic acidosis associated with metformin overdose. Although low blood sugar is uncommon with this combination when used alone, it may occur when taken with other antidiabetic medicines. If you suspect an overdose, seek medical attention immediately.
- If you miss a dose of Metformin + Teneligliptin, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.
Management Of Side Effects
- Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. To combat hypoglycemia, eat or drink a source of sugar such as fruit juice, candy, crackers, raisins, or non-diet soda. Once your blood sugar stabilises, have a balanced snack or meal to prevent another drop. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.
Use In Driving And Operating Machinery
- Metformin and Teneligliptin can make you feel dizzy. It is not recommended to drive, operate machinery, or do other activities that require mental alertness or coordination till you know how the combination affects you.
Use In Pregnancy And Lactation
- Caution is advised while taking this combination during pregnancy. This combination is not recommended for breastfeeding.
Caution In Other Conditions
- Caution is advised in older adults and patients with diabetic ketoacidosis, pancreatitis, joint pain, irregular heartbeat, hypoglycaemia (low blood sugar), vitamin B12 deficiency and kidney and liver impairment.
Special Dietary And Lifestyle Recommendation
- Incorporate foods with low glycemic index, such as green leafy vegetables, whole grains, berries, citrus fruits, chia seeds, bitter gourd and extra virgin olive oil.
- Engage in regular physical activity, which can help improve insulin sensitivity and blood sugar control.
- Watch your sodium intake and not exceed 5g daily to avoid heart conditions with diabetes.
- Monitor your blood sugar levels regularly and stay connected with your doctor to adjust your treatment plan.
Frequently asked questions
1. How much time do Metformin and Teneligliptin take to work?
Metformin and Teneligliptin typically show their effects within a few hours after ingestion. However, individual responses may vary.
2. Is the combination of Metformin and Teneligliptin a habit-forming medicine?
The combination of Metformin and Teneligliptin is not habit-forming and is generally safe when used as directed.
3. Does the combination of Metformin and Teneligliptin affect fertility?
The use of this combination is not known to impair female fertility.
4. Is the Metformin and Teneligliptin combination available over the counter, or do I need a prescription?
The combination of Metformin and Teneligliptin usually requires a prescription and is not available over the counter.
5. What is the best time to take Metformin and Teneligliptin combination?
The best time to take this combination is typically with your meal to reduce the risk of stomach upset. However, always follow your doctor’s specific instructions while prescribing this tablet.
6. Is Metformin and Teneligliptin combination safe?
This combination is generally considered safe when used as prescribed and monitored by a doctor. However, individuals with diabetic ketoacidosis, pancreatitis, joint pain, irregular heartbeat, and hypoglycaemia (low blood sugar) should consult a doctor before taking this tablet.
7. Does Metformin and Teneligliptin combination reduce weight?
This combination may lead to modest weight loss in some individuals. Consult your doctor if you have any concerns.
8. Does Metformin and Teneligliptin combination cause constipation?
This combination may cause constipation as a side effect. However, individual responses may vary. If you have persistent constipation while taking this combination, consult your doctor.
9. Can Metformin and Teneligliptin combination be used for type 1 diabetes?
This combination is not recommended to manage type 1 diabetes. It is used only for type 2 diabetes.
10. Can the use of Metformin + Teneligliptin lead to hypoglycemia?
The combination of Metformin and Teneligliptin typically has a low risk of causing hypoglycemia (low blood sugar) when used alone. However, the risk may increase if taken with other antidiabetic medications, insulin, or if meals are skipped.
11. Can the use of Metformin + Teneligliptin cause lactic acidosis?
Yes, Metformin, when combined with Teneligliptin, can potentially cause lactic acidosis, a rare but serious condition. This risk is higher in patients with kidney problems, liver disease, or excessive alcohol consumption.
12. Can the use of Metformin + Teneligliptin lead to Vitamin B12 deficiency?
Yes, long-term use of Metformin, including in combination with Teneligliptin, can lead to Vitamin B12 deficiency. Regular monitoring and supplementation, if necessary, may be recommended by your healthcare provider.
13. What is Metformin + Teneligliptin used for?
Metformin + Teneligliptin is used to manage Type 2 Diabetes by helping control blood sugar levels. Metformin works by reducing sugar production in the liver and improving the body's sensitivity to insulin, while Teneligliptin increases insulin secretion and reduces glucose production by affecting incretin hormones. Together, they help keep blood sugar levels stable, reduce the risk of complications, and improve overall diabetes management. This combination is commonly prescribed when diet and exercise alone are not enough.
List of medicines for Metformin + Teneligliptin
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