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Metronidazole + Nalidixic Acid

Uses of Metronidazole + Nalidixic Acid

  • Metronidazole + Nalidixic Acid is primarily used to manage a variety of bacterial infections. This combination belongs to the group of antibiotics.

  • It is also used in diagnosing and managing conditions such as diarrhoea, dysentery, vaginal infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, dental infections as well as parasitic infections like amoebiasis and giardiasis.

Side effects of Metronidazole + Nalidixic Acid

  • Nausea

  • Vomiting

  • Abdominal pain or cramps

  • Headache

  • Dark-coloured urine

How Metronidazole + Nalidixic Acid works

  • Metronidazole + Nalidixic Acid is a combination of two antibiotics.

  • Metronidazole is a type of antibiotic known as a nitroimidazole. It works by entering bacterial cells and stopping the production of some of the bacteria's key genetic materials. This results in the death of the bacteria and helps to get rid of the infection.

  • Nalidixic Acid is a quinolone antibiotic. It manages bacterial infections by blocking an enzyme called DNA-gyrase, which is needed by the bacteria to reproduce and repair themselves. If this enzyme does not work, the bacteria cannot reproduce or repair themselves and this leads to their death.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Metronidazole + Nalidixic Acid is available for oral administration in the form of tablets and suspension form.

Age and Dose Restrictions

  • This medicine is meant for use in adults and children above 12 years of age.

Contraindications

  • Metronidazole + Nalidixic Acid is contraindicated in patients with known allergies to either metronidazole or nalidixic acid.

  • The combination is also contraindicated in patients with a history of blood disorders, liver disease, or neurological conditions.

Other Medications to Avoid

  • Metronidazole + Nalidixic Acid may interact with anticoagulants (such as warfarin, heparin), antiepileptics (like phenytoin, phenobarbital), certain gastrointestinal medications (like cimetidine, ranitidine) and immunosuppressants (like cyclosporine, tacrolimus ).

Overdose and Missed Dose

  • An overdose of Metronidazole + Nalidixic Acid may cause nausea, vomiting, dizziness and neurological symptoms. If you suspect an overdose, seek immediate medical attention.

  • If you miss a dose of Metronidazole + Nalidixic Acid, you should take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and return to your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage nausea or upset stomach, try taking this medication with or after a meal or snack.

  • Drinking small amounts of ginger tea or adding fresh ginger to food may help relieve nausea and vomiting.

  • Staying well hydrated may help manage diarrhoea, dark-coloured urine or other fluid-related side effects.

Use in Driving and Operating Machinery

  • Dizziness is a known side effect of Metronidazole + Nalidixic Acid. If you experience dizziness or any other side effect that could affect your ability to concentrate and react, you should avoid driving or operating machinery.

Use in Pregnancy and Lactation

  • The use of Metronidazole + Nalidixic Acid during pregnancy, particularly during the first trimester, is not recommended due to potential risks to the foetus.

  • Breastfeeding mothers should also consult their doctor before using this medication.

Caution in Other Conditions

  • Patients with liver disease or kidney disease should use Metronidazole + Nalidixic Acid with caution as these conditions may alter the effectiveness and safety of this medication.

Special Dietary and Lifestyle Recommendations

  • Regular hand hygiene can reduce the risk of bacterial and parasitic infections.

  • Safe food handling and cooking practices can help prevent gastrointestinal infections.

  • For infections of the female reproductive system, maintaining good personal hygiene is important.

  • Regular dental check-ups can help prevent dental infections.

Frequently asked questions

No, Metronidazole + Nalidixic Acid is not a steroid. It is a combination of two antibiotics.

Metronidazole + Nalidixic Acid is not associated with affecting sleep disturbances. However, individual reactions to medicines can vary, and if you experience changes in your sleep patterns while taking this medicine, consult your doctor.

Metronidazole + Nalidixic Acid is not directly associated with affecting fertility. If you have concerns about fertility related issues, consult your doctor.

Metronidazole + Nalidixic Acid should be taken as recommended by your doctor. The duration and frequency of use depend on the type and severity of the infection being managed.

The exact time for Metronidazole + Nalidixic Acid to start showing its effects may vary depending on the type and severity of the infection. For specific information, consult your doctor.

Metronidazole + Nalidixic Acid is usually prescribed by a doctor and is not available over the counter.

The best time to take Metronidazole + Nalidixic Acid is as directed by your doctor. Following the prescribed schedule accurately helps ensure the effectiveness of the medication.

Terms & Conditions


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