Metformin + Vildagliptin
AntidiabeticUses of Metformin + Vildagliptin
Metformin + Vildagliptin is a combination medicine used to manage blood sugar levels in adults with type 2 diabetes.
This combination is commonly used for:
- Type 2 diabetes mellitus: Helps lower and control blood glucose levels alongside diet and exercise.
- Insulin resistance: Improves the body's sensitivity to insulin and reduces glucose production by the liver.
- Combined blood sugar management: Used when both improved insulin action and increased incretin hormone activity are needed to control blood sugar
Side effects of Metformin + Vildagliptin
- Hypoglycemia
- Dizziness
- Headache
- Nausea
How Metformin + Vildagliptin works
- Metformin + Vildagliptin works through two different mechanisms to help control blood sugar levels in people with type 2 diabetes.
- Metformin is a biguanide. It reduces the amount of glucose produced by the liver and improves the body's sensitivity to insulin, helping cells absorb glucose from the blood more effectively.
- Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It blocks the enzyme that breaks down natural hormones called incretins, which help the body release insulin after meals and reduce the amount of glucagon, a hormone that raises blood sugar.
- Together, Metformin lowers the background glucose produced by the liver while Vildagliptin improves the body's own insulin response after meals, providing more complete blood sugar control
Certified content
Written By
MBBS
Reviewed By
MBBS, DNB (OBGY)
Expert Advice
Dosage Forms Available
- Metformin + Vildagliptin can be combined orally (tablet).
Age And Dose Restrictions
- This combination is not intended to be used by children below 18 years.
Contraindications
- This combination is contraindicated in patients with a history of hypersensitivity to metformin or vildagliptin.
Other Medications To Avoid With This Medicine
- Avoid taking antifungals (ketoconazole), antidepressants (fluoxetine), antihypertensives (amlodipine), diuretics (furosemide), thyroid medications (levothyroxine), corticosteroids (prednisolone), phenothiazines (serentil), estrogens (estradiol), oral contraceptives (norethindrone), anticonvulsants (phenytoin), and antiepileptics. These medications may alter the safety and effectiveness of Metformin + Vildagliptin.
Overdose And Missed Dose
- Taking more than the prescribed dose may cause lactic acidosis, a serious condition that requires immediate medical attention. Strict adherence to the prescribed dose is essential.
- If you miss a dose of Metformin + Vildagliptin, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.
Management Of Side Effects
- To manage hypoglycemia (low blod sugar), eat or drink a source of sugar such as fruit juice, candy, crackers, raisins, or non-diet soda. Once your blood sugar stabilises, have a balanced snack or meal to prevent another drop. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.
Use In Driving And Operating Machinery
- This combination can make you feel dizzy. It is not recommended to drive, operate machinery, or do other activities that require mental alertness or coordination till you know how the combination affects you.
Use In Pregnancy And Lactation
- This combination is not recommended during pregnancy and breastfeeding.
Caution In Other Conditions
- Caution is advised in older adults and patients with diabetic ketoacidosis, pancreatitis, joint pain, irregular heartbeat, hypoglycaemia (low blood sugar), vitamin B12 deficiency and kidney and liver impairment.
Special Dietary And Lifestyle Recommendation
- Incorporate foods with low glycemic index, such as green leafy vegetables, whole grains, berries, citrus fruits, chia seeds, bitter gourd and extra virgin olive oil.
- Engage in regular physical activity, which can help improve insulin sensitivity and blood sugar control.
- Watch your sodium intake and not exceed 5 gm daily to avoid heart conditions with diabetes.
- Monitor your blood sugar levels regularly and stay connected with your doctor to adjust your treatment plan.
Frequently asked questions
1. How much time does Metformin + Vildagliptin take to work?
This combination typically shows its effect within a few hours after ingestion. However, individual responses may vary.
2. Is Metformin + Vildagliptin a habit-forming medicine?
This combination is not habit-forming and is generally safe when used as directed.
3. Does Metformin + Vildagliptin affect fertility?
The use of this combination is not known to impair female fertility.
4. Is Metformin + Vildagliptin available over the counter, or do I need a prescription?
This combination usually requires a prescription and is not available over the counter.
5. Is Metformin + Vildagliptin safe?
This combination is generally considered safe when used as prescribed and monitored by a doctor. However, individuals with diabetic ketoacidosis, pancreatitis, joint pain, irregular heartbeat, and hypoglycaemia (low blood sugar) should consult a doctor before taking this tablet.
6. Does Metformin + Vildagliptin cause constipation?
This combination may cause constipation as an uncommon side effect. However, individual responses may vary. If you have persistent constipation while taking this combination, consult your doctor.
7. Can Metformin + Vildagliptin be used for type 1 diabetes?
This combination is not recommended to manage type 1 diabetes. It is used only for type 2 diabetes.
8. What is the use of Metformin + Vildagliptin?
This combination is used to manage type 2 diabetes mellitus when diet and exercise alone are insufficient. It improves insulin sensitivity and increases incretin activity to help control blood glucose levels.
List of medicines for Metformin + Vildagliptin
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