Empagliflozin + Linagliptin
AntidiabeticUses of Empagliflozin + Linagliptin
- Empagliflozin + Linagliptin combines two antidiabetic medicines used as a combination therapy for managing Type 2 Diabetes along with diet and exercise.
- This combination functions to augment postprandial insulin secretion and diminish endogenous glucose production in the body.
Side effects of Empagliflozin + Linagliptin
- Nasopharyngitis
- Urinary tract infection
- Nausea
- Vomiting
- Constipation
- Hypoglycemia
- Cough
- Genital Fungal Infection
How Empagliflozin + Linagliptin works
- Empagliflozin functions as an inhibitor of SGLT2, the primary transporter responsible for reabsorbing glucose from the glomerular filtrate into the circulation. Its action involves the inhibition of SGLT2, leading to reduced renal reabsorption of filtered glucose and decreased renal threshold for glucose. Consequently, empagliflozin enhances urinary glucose excretion. Beyond its impact on glucose dynamics, it also diminishes sodium reabsorption, promoting increased delivery of sodium to the distal tubule. This modulation of sodium handling may exert various physiological effects, including the reduction of both pre- and afterload on the heart and the downregulation of sympathetic activity.
- Linagliptin is an inhibitor of DPP-4, an enzyme that breaks down incretin hormones, namely glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Consequently, it elevates the concentrations of active incretin hormones, promoting insulin release in a glucose-dependent manner and reducing circulating glucagon levels. GLP-1 and GIP play vital roles in the physiological regulation of glucose homeostasis. Incretin hormones are continuously secreted at basal levels throughout the day, with levels surging immediately after a meal consumption. GLP-1 and GIP enhance insulin biosynthesis and secretion from pancreatic beta cells, particularly in the presence of normal and elevated blood glucose levels. Additionally, GLP-1 diminishes glucagon secretion from pancreatic alpha cells, leading to a decrease in hepatic glucose output.
Certified content
Written By
B. Pharm
Reviewed By
B. Pharm, MSc.
Expert Advice
Dosage Forms Available
- Empagliflozin + Linagliptin is available for use via the oral route (tablets).
Age and Dose Restrictions
- This combination is meant for use in adults and children above 18 years of age.
Contraindications
- This combination is contraindicated in patients with allergies to empagliflozin or linagliptin or in case of severe renal dysfunction and heart problems.
Other Medications To Avoid With This Medicine
- The simultaneous use of medications, including beta-blockers (such as metoprolol, propranolol, and glaucoma eye drops like timolol), antidiabetic medications (such as glimepiride and insulin glargine), and antimanic agents (lithium), alongside [unspecified medication], is not recommended. Prior consultation with a doctor is essential before considering the use of any prescription or over-the-counter medications to ensure the safety of the combined treatment plan.
Overdose and Missed Dose
- In case of an overdose of this combination, consult your doctor if you experience severe side effects or worsening of any of the symptoms and follow the advice accordingly.
- If you forget to take this combination, take it as soon as you remember. However, avoid repeating the dose.
Use In Driving And Operating Machinery
- This combination does not directly impact your ability to drive or operate machinery. However, they may lead to hypoglycemia, which can cause dizziness. Taking precautions to prevent low blood sugar while driving or handling machinery is essential.
Use in Pregnancy and Lactation
- This combination is not recommended in pregnant and breastfeeding women.
Special Dietary & Lifestyle Recommendation
- Making lifestyle changes, including dietary modifications and regular exercise, is essential when taking this combination to control blood sugar levels properly.
- After initiating treatment with this combination, it's recommended to have your blood sugar levels reassessed after 15 days and, subsequently, at regular intervals every 3-6 months. This monitoring helps track the progress of the disease and allows for dose adjustments as needed.
- If hypoglycemia occurs, it's essential to have a quick source of sugar readily available. Carry sugar candies, glucose tablets, or sugary foods and drinks without fat or protein, such as fruit juice, to promptly address low blood sugar episodes.
Frequently asked questions
1. How much does Empagliflozin + Linagliptin take to work?
This combination may start to work within a few hours, but it may take some time to see the full effects. It's important to continue taking it as your doctor prescribes, even if you start feeling better.
2. What warnings and precautions should I take while taking Empagliflozin + Linagliptin?
While taking this combination, be cautious to avoid hypoglycemia (low blood sugar). Avoid taking it if you are allergic to empagliflozin or linagliptin.
3. Should I stop taking Empagliflozin + Linagliptin if I feel healthy?
Do not stop taking this combination without consulting your doctor, even if you feel healthy. Abruptly discontinuing this medication can lead to uncontrolled blood sugar levels.
4. Does Empagliflozin + Linagliptin affect fertility?
No, this combination typically does not affect fertility. However, if you have concerns about fertility and its impact on diabetes management, discuss them with your doctor.
Empagliflozin + Linagliptin in other salts
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