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Ofloxacin + Ornidazole

Antibiotic

Uses of Ofloxacin + Ornidazole

Ofloxacin + Ornidazole is a combination medicine used for selected gastrointestinal infections caused by susceptible bacteria, anaerobic organisms, or protozoa.
This combination is commonly used for:
• Infectious diarrhoea: May be prescribed for acute diarrhoea caused by susceptible bacteria or protozoa when antimicrobial treatment is needed.
• Dysentery: Treats selected cases of bacterial or amoebic dysentery, as directed by a doctor.
• Mixed gastrointestinal infections: Targets susceptible aerobic bacteria, anaerobic bacteria, and protozoa when more than one type of organism is involved.
• Amoebiasis with suspected bacterial co-infection: May be used when both amoebic and bacterial causes require treatment.
• Giardiasis with suspected bacterial co-infection: May be used in selected mixed infections under medical supervision.
• Other confirmed mixed infections: Used only when a clinician determines that both components are appropriate for the likely or confirmed organisms.

Side effects of Ofloxacin + Ornidazole

The  side effects of Ofloxacin + Ornidazole are:

  • Nausea and vomiting
  • Abdominal pain
  • Headache
  • Dizziness
  • Insomnia (difficulty in sleeping)
  • Itching
  • Vaginal inflammation
  • Diarrhoea

How Ofloxacin + Ornidazole works

Ofloxacin + Ornidazole works through two separate actions against susceptible bacteria, anaerobic organisms, and protozoa in selected infections.

Ofloxacin is a fluoroquinolone antibiotic. It blocks bacterial DNA gyrase and topoisomerase IV, enzymes that susceptible bacteria need to copy and repair their DNA. This stops bacterial multiplication.

Ornidazole is activated inside anaerobic bacteria and protozoa and forms compounds that damage their DNA. This prevents the organisms from reproducing and leads to their destruction.

Together, these medicines provide antibacterial and antiprotozoal activity when a mixed infection has been diagnosed or is strongly suspected."

Together, Ofloxacin and Ornidazole cover a broader range of infections than either medicine alone. Ofloxacin targets aerobic bacteria, while Ornidazole targets anaerobic bacteria and certain protozoa, making this a useful treatment for mixed infections.

Certified content

Written By

docImg
Dr. Sachin SinghMedical Team Lead & Reviewer| 7 years

MBBS

Reviewed By

Dr. Mandeep Chadha
Dr. Mandeep ChadhaLead Medical Content Reviewer| 12 years

MBBS, DNB (OBGY)

Expert Advice

Dosage Forms Available for Ofloxacin + Ornidazole

  • Ofloxacin + Ornidazole can be taken orally (tablet).

Age And Dosage Restrictions for Ofloxacin + Ornidazole

  • This combination is intended for adults and children. 

Contraindications of Ofloxacin + Ornidazole

  • This combination is contraindicated in patients with a history of hypersensitivity to ofloxacin or ornidazole. It is also contraindicated in patients having central nervous system disease, peripheral nervous system disease, liver and kidney impairment. 

Medications To Avoid With Ofloxacin + Ornidazole 

  • Avoid taking antidiabetics (insulin), stomach acid reducers (cimetidine), bronchodilators (theophylline), anticoagulants (warfarin), medicines or dietary supplements containing iron or zinc, antacids (aluminium hydroxide), corticosteroids (prednisone), and anti-inflammatory medications (ibuprofen) with Ofloxacin + Ornidazole. These medications may alter the safety and effectiveness of Ofloxacin + Ornidazole.

Overdose And Missed Dose

  • Taking more than the prescribed dose may cause nausea, vomiting, dizziness, headache, or seizures. If you accidentally take an overdose and notice any worsening of symptoms, contact your doctor or visit the nearest hospital without delay. Strict adherence to the prescribed dose is essential.
  • If you miss a dose of Ofloxacin + Ornidazole, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time. Completing the full prescribed course is important to prevent the infection from returning or becoming resistant to antibiotics.

Management Of Side Effects

  • Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

  • This medicine can cause dizziness. It is not recommended to drive, operate machinery, or do other activities that require mental alertness or coordination after taking this medicine. 

Use In Pregnancy And Lactation

  • This combination is not recommended during pregnancy and breastfeeding.

Caution In Other Conditions

  • Caution is advised in older adults and patients with heart conditions, severe coagulation disorders and kidney and liver impairment.

Special Dietary And Lifestyle Recommendation

  • Take clear fluids like water, oral rehydration solutions, and diluted fruit juices. You can make an oral rehydration solution by mixing salt, sugar, and water to replenish electrolytes.
  • Dairy products and fatty foods can worsen diarrhoea. Avoid giving these until the symptoms improve.
  • Take foods with natural probiotics, like yoghurt, to help restore the balance of beneficial gut bacteria.
  • Give the smaller, more frequent meals to avoid stomach discomfort.
  • Emphasise the importance of keeping any cuts or wounds clean and properly covered to prevent skin infection from aggravating.

Frequently asked questions

Ofloxacin + Ornidazole is used to treat mixed infections caused by bacteria and parasites. It is commonly prescribed for conditions such as severe diarrhoea, dysentery, stomach and intestinal infections, and certain gynaecological infections. This combination works by stopping the growth of harmful germs, helping control the infection and supporting faster recovery.

Yes, Ofloxacin + Ornidazole treats loose motions.

It is advisable to avoid alcohol while on Ofloxacin + Ornidazole.

Store Ofloxacin + Ornidazole at room temperature below 30°C away from moisture. For disposal, follow the instructions on the package insert or contact your nearest pharmacist.

This suspension can be used to treat diarrhoea associated with mixed infections, providing a comprehensive approach to address both bacterial and protozoal causes.

This suspension should be taken with or immediately after a meal as per your doctor’s advice, as it will help minimise the risk of stomach upset and enhance medication absorption. Consistency in the timing of administration is essential for optimal effectiveness.

The duration of treatment with this combination varies based on the specific infection and severity, and it should be given for the full prescribed course as directed by your doctor even if symptoms improve before completion. Follow the recommended treatment duration for optimal effectiveness.

Patients with a history of severe neurological disorders, kidney and liver impairment should not be given this combination without a doctor’s prescription.

This combination may rarely cause severe liver damage.

Yes, Ofloxacin + Ornidazole treats loose motions.It Also used to treat infectious diarrhea. It helps control bowel movements, fight the infection, and prevent symptoms from coming back.

Terms & Conditions


List of medicines for Ofloxacin + Ornidazole

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