Naphazoline + Phenylephrine is an eye medicine used to relieve redness, puffiness, itching, and watering caused by minor eye irritation.
This combination is commonly used for:
• Minor eye irritation: Relieves redness and discomfort caused by dust, smoke, smog, pollen, or animal dander.
• Eye irritation from contact lens use or swimming: Eases redness and irritation linked to these activities.
• Allergic eye symptoms: Relieves itching and watering associated with hay fever or other upper respiratory allergies.
Temporary burning or stinging of the eye
Increased redness of the eye
Blurred vision
Headache or dizziness
Nervousness or drowsiness
Naphazoline + Phenylephrine works through two similar mechanisms to relieve eye redness and irritation.
Naphazoline acts on alpha receptors in the blood vessels of the conjunctiva, the clear membrane covering the eye. This causes the blood vessels to narrow, which reduces redness and eases minor irritation.
Phenylephrine also acts on alpha receptors, narrowing blood vessels in the eye. It additionally acts on the muscle that controls the pupil, causing mild pupil dilation.
Together, Naphazoline and Phenylephrine reduce redness and provide relief from minor eye irritation.

MSc (Applied Genetics)

BAMS, FMC, MD Resident
Naphazoline + Phenylephrine is available in the form of a sterile ophthalmic solution for use via the topical route, to be applied directly to the eyes.
This medicine is designed for use by adults and children who are 6 years of age or older.
Naphazoline + Phenylephrine is contraindicated in patients with narrow-angle glaucoma or known hypersensitivity or allergy to any of the ingredients in this medication.
This combination may interact with monoamine oxidase inhibitors (such as selegiline, isocarboxazid), tricyclic antidepressants (like amitriptyline, nortriptyline), beta-blockers (including atenolol, propranolol), anti-hypertensives (such as amlodipine, lisinopril), and cardiac glycosides (such as digoxin).
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Try to take the medicine at a time when you can rest and recover from the side effects, such as before bedtime.
Drink plenty of fluids to help ease the side effects and keep your body hydrated.
Naphazoline + Phenylephrine may cause CNS depression, including drowsiness or dizziness. As such, it is advisable to avoid driving or operating heavy machinery while using this medication.
This combination should be used only if prescribed by a doctor during pregnancy
Nursing mothers should use this medication only after medical consultation.
Naphazoline + Phenylephrine should be used with caution in patients with heart disease, high blood pressure, diabetes or hyperthyroidism due to the potential for increased cardiovascular toxicity.
Maintain clean eyes by avoiding touching them with dirty hands or exposing them to dust and irritants.
Regularly clean your contact lenses as per the manufacturer's instructions.
Try to avoid exposure to allergens known to trigger your symptoms such as dust, pollen, animal hair and dander.
Practice good eye hygiene by washing your eyes with clean water regularly.
If you are prone to allergies, wearing protective eyewear outdoors could help reduce eye irritation.
Frequently asked questions
No, Naphazoline + Phenylephrine is not a steroid. It consists of two decongestant medications known for their efficacy in relieving minor eye irritations.
Although Naphazoline + Phenylephrine is primarily used for eye relief, it can potentially cause central nervous system depression, which may result in drowsiness or nervousness.
There is no specific contraindication for using Naphazoline + Phenylephrine during menstruation. However, if you experience any discomfort or unusual side effects, consult your doctor.
There is no clear information about the vegan status of Naphazoline + Phenylephrine. It is recommended to check the product packaging or consult your doctor or pharmacist for detailed information.
Naphazoline + Phenylephrine is not known to cause addiction or dependence. However, prolonged use may lead to rebound congestion or chronic eye redness.
As Naphazoline + Phenylephrine is not an addictive substance, stopping its use suddenly should not trigger withdrawal symptoms. Nevertheless, always consult your doctor before making changes to your medication regimen.
Naphazoline + Phenylephrine should be used with caution in patients with high blood pressure. Although it is primarily used for eye conditions, it can potentially impact blood pressure levels.
Naphazoline + Phenylephrine in other salts
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