Hydrochlorothiazide + Quinapril is used to manage high blood pressure (hypertension). It combines a diuretic with an ACE inhibitor to help control blood pressure more effectively than either medicine alone.
This combination is commonly used for:
• Hypertension: Lowers high blood pressure and helps reduce the risk of complications such as heart attack and stroke.
• Fluid retention (oedema) associated with hypertension: Reduces excess fluid build-up, thereby supporting blood pressure control.
• Long-term blood pressure control: Used as part of ongoing management to keep blood pressure within a healthy range.
Dizziness or lightheadedness
Fatigue or weakness
Dry cough
Nausea or vomiting
Increased urination

Doctor of Medicine

BAMS, FMC, MD Resident
Hydrochlorothiazide + Quinapril is available for use as tablets, which are taken orally.
This medicine is meant for adults only.
This medicine is contraindicated in patients with known allergies to quinapril, hydrochlorothiazide, or other ACE inhibitors or sulfa medicines.
This medicine is contraindicated in patients with severe kidney or liver disease and in those with anuria (complete absence of urine production).
This combination may interact with potassium supplements or potassium-sparing diuretics (such as spironolactone and triamterene), lithium, nonsteroidal anti-inflammatory drugs (NSAIDs like ibuprofen and naproxen), insulin, or oral diabetes medications (such as metformin and glyburide).
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If experiencing dizziness or lightheadedness, try sitting or lying down until the feeling passes.
Stay well hydrated to help manage minor side effects such as dry mouth or thirst.
This medication may impair your ability to drive or operate machinery. Avoid such activities until you know how Hydrochlorothiazide + Quinapril affects you, especially if you feel dizzy or sleepy.
Hydrochlorothiazide + Quinapril is not recommended during pregnancy or while breastfeeding. It could potentially cause harm to the baby. It is crucial to consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before using this medication.
Patients with renal (kidney) conditions should approach the use of Hydrochlorothiazide + Quinapril with caution due to potential worsening of kidney function.
Patients with liver conditions should also be cautious, as dose adjustments might be needed due to slow medicine metabolism.
Regular monitoring of electrolytes is important due to potential imbalances caused by the diuretic effect.
Maintain a diet low in sodium. Aim for less than 2 grams of sodium per day.
Include potassium-rich foods like bananas, oranges, and spinach, but do so under guidance from your doctor since potassium levels need careful management when taking this medication.
Engage in regular physical activity such as walking, jogging, or swimming for at least 30 minutes most days of the week.
Limit intake of alcohol as it can increase blood pressure and may reduce the effectiveness of this medicine.
Frequently asked questions
No, Hydrochlorothiazide + Quinapril is not a steroid. It is a combination medication that includes a diuretic (hydrochlorothiazide) and an angiotensin-converting enzyme (ACE) inhibitor (quinapril).
The side effects of Hydrochlorothiazide + Quinapril can vary from person to person. Some people might experience dizziness or lightheadedness, which could potentially affect sleep. However, this is not a commonly reported effect.
Hydrochlorothiazide + Quinapril is generally safe for long-term use if taken as directed by your doctor. It is important to monitor your health and consult your doctor regularly while on this medication.
If you have kidney disease, Hydrochlorothiazide + Quinapril should be used with caution. This is because the medication can potentially worsen kidney function. Always consult your doctor before starting any new medication.
Weight gain is not a common side effect of Hydrochlorothiazide + Quinapril. However, if you experience sudden weight gain or swelling in the hands, ankles, or feet, it could be a sign of fluid retention, and you should contact your doctor.
You should only take potassium supplements while on Hydrochlorothiazide + Quinapril under the direction of your doctor, as this combination can lead to dangerously high levels of potassium.
While it's uncommon, Hydrochlorothiazide + Quinapril could potentially cause mood changes in some individuals. If you experience any unusual changes in mood or behavior, contact your doctor immediately.
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