Chlorpheniramine is an antihistamine used to relieve allergy symptoms and cold-related symptoms.
It is commonly used for:
• Allergic rhinitis: Relieves sneezing, a runny nose, and itchy, watery eyes caused by allergies.
• Urticaria (hives): Reduces itching and skin welts caused by allergic reactions.
• Common cold symptoms: Helps relieve sneezing and a runny nose associated with colds.
• Insect bite and sting reactions: Eases itching and swelling caused by allergic reactions to bites and stings.
• Allergic conjunctivitis: Helps relieve itching and watering of the eyes caused by allergens.
Drowsiness
Dizziness
Dry mouth, nose, and throat
Headache
Nausea and vomiting
Chlorpheniramine works by blocking histamine, a chemical the body releases during an allergic reaction.
When the body encounters an allergen, immune cells release histamine, which binds to receptors in the nose, eyes, and skin, triggering symptoms such as sneezing, itching, and swelling.
By blocking these histamine (H1) receptors, chlorpheniramine prevents or reduces the severity of allergy symptoms. As an older, first-generation antihistamine, it can cross into the brain more readily than newer antihistamines, which is why drowsiness is a common effect.

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BAMS, FMC, MD Resident
Chlorpheniramine is available in oral tablets, capsules, syrups, and oral suspensions, and can also be administered as an injectable solution.
This medicine is meant for adults and children. Specific age and dose restrictions apply, particularly concerning the use of certain formulations in younger children.
Chlorpheniramine is contraindicated in patients with known hypersensitivity to the medicine or any of its components.
This medicine may interact with antidepressants (such as amitriptyline and sertraline), sedatives (like diazepam and lorazepam), anticholinergics (including atropine and scopolamine), and MAO inhibitors (such as phenelzine and tranylcypromine).
Before starting any new medications, consulting a doctor is essential to avoid potentially harmful interactions.
An overdose of Chlorpheniramine may lead to symptoms such as extreme drowsiness, confusion, or agitation. It is critical to seek medical attention immediately if an overdose is suspected.
If you miss a dose of this medicine, take it as soon as you remember unless it is nearly time for your next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
For dry mouth or throat, sipping water regularly may help.
If experiencing drowsiness, adjusting the times when you take the medication may be beneficial – avoid taking it before activities requiring alertness.
Chlorpheniramine may cause drowsiness or dizziness, affecting your ability to drive or operate heavy machinery. Avoid these activities if you experience these side effects.
Pregnant or breastfeeding women should consult their doctor before using Chlorpheniramine. The safety of this medicine during pregnancy or breastfeeding has not been fully established.
Patients with conditions like glaucoma, difficulty urinating due to an enlarged prostate, or those with asthma should exercise caution when using Chlorpheniramine.
Individuals with high blood pressure or heart disease should consult their doctor before starting this medicine due to the potential risks associated with its use.
To manage allergies effectively, it is recommended to avoid known allergens in both diet and environment.
Maintaining a clean environment by regularly cleaning dust-prone areas in the house can reduce allergy symptoms.
For those with respiratory allergies, using an air purifier in living spaces can help remove airborne allergens.
Staying hydrated by drinking plenty of water can assist in thinning mucus secretions associated with some allergic reactions.
Frequently asked questions
No, Chlorpheniramine is not a steroid. It is an antihistamine medication that belongs to the class of first-generation antihistamines.
Yes, one of the common side effects of Chlorpheniramine is drowsiness. This could potentially affect sleep by causing an individual to feel sleepy or drowsy after taking the medicine.
There is currently no evidence or scientific research to suggest that Chlorpheniramine has any effect on fertility. However, if you have any concerns about this, it is recommended you consult your doctor.
No particular dietary restrictions are required for patients taking Chlorpheniramine. However, it is always advisable to maintain a balanced and healthy diet whilst taking any medicine.
Chlorpheniramine should be taken as per the instructions and dosage prescribed by your doctor. Daily usage will depend on the individual's medical condition and their body's response to the medicine.
The onset of action for Chlorpheniramine is typically within 30 minutes to 1 hour, with effects lasting 4 to 6 hours for regular formulations and 8 to 12 hours for extended-release formulations.
The best time to take Chlorpheniramine will largely depend on the individual's schedule and the specifics of their medical condition. Your doctor will be able to provide more personalised advice in this regard.
Chlorpheniramine in other salts
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