Amlodipine + Valsartan

Dosage Forms Available

• Amlodipine + Valsartan is available in the form of oral tablets.
• This combination medicine is meant to be taken by mouth.

Age and Dose Restrictions

• This medicine is intended for use by adults only.

Contraindications

• Amlodipine + Valsartan is contraindicated in patients with known hypersensitivity to amlodipine, valsartan, or any of the inactive components of the tablets.
• It is also contraindicated in patients with severe hepatic impairment, biliary cirrhosis, and cholestasis.

Other Medications to Avoid

• This combination may interact with aliskiren (such as Tekturna), ACE inhibitors (like lisinopril and ramipril), potassium-sparing diuretics (such as spironolactone and triamterene), NSAIDs (like ibuprofen and naproxen), simvastatin, CYP3A4 inhibitors (e.g., diltiazem, itraconazole, clarithromycin), and CYP3A4 inducers (e.g., rifampin, St. John's wort).

Overdose and Missed Dose

• Taking more than the prescribed dose of Amlodipine + Valsartan may cause a significant drop in blood pressure (severe hypotension), leading to dizziness, lightheadedness, fainting, rapid heartbeat, and in serious cases, acute kidney failure. If an overdose is suspected, seek emergency medical attention immediately. Do not attempt to manage symptoms at home.
• If you miss a dose of Amlodipine + Valsartan, take it as soon as you remember. If it is nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• To manage dizziness or lightheadedness, it may help to get up slowly from a sitting or lying position.
• Staying hydrated can help manage dizziness and fatigue associated with these medicines.

Use in Driving and Operating Machinery

• This medication may impair your ability to drive or operate machinery. You should avoid driving or engaging in activities requiring alertness if you experience dizziness or sleepiness after taking this medication.

Use in Pregnancy and Lactation

• Amlodipine + Valsartan is contraindicated during pregnancy due to the risk of harm to the foetus. It should not be used during breastfeeding as it is unknown if the components pass into breast milk.
• It is crucial to consult your doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

• Patients with renal impairment or those at risk for electrolyte imbalances should exercise caution when taking Amlodipine + Valsartan.
• Individuals with dehydration or those undergoing major surgery that involves substantial fluid shifts should also be cautious.

Special Dietary and Lifestyle Recommendations

• Maintain a low-sodium diet to help manage hypertension effectively. Avoid high-salt foods such as processed meats, canned soups, and fast foods.
• Incorporate potassium-rich foods like bananas, oranges, and leafy greens into your diet unless otherwise advised by your doctor.
• Regular physical activity such as walking, cycling, or swimming can help lower blood pressure.
• Monitor weight regularly to ensure healthy body weight maintenance which supports blood pressure management.
• Manage stress through relaxation techniques like yoga, meditation, or deep breathing exercises.