Alfuzosin + Dutasteride
Uses of Alfuzosin + Dutasteride
Alfuzosin + Dutasteride is used to manage symptoms of benign prostatic hyperplasia (BPH), a non-cancerous enlargement of the prostate gland in men. Alfuzosin is an alpha-blocker that relaxes muscles around the bladder and prostate, and Dutasteride is a 5-alpha reductase inhibitor that helps shrink the prostate over time.
This combination is commonly used for:
• Benign prostatic hyperplasia (BPH): Relieves symptoms such as difficulty urinating, weak urine stream, and a frequent urge to urinate.
• Reduced urine flow associated with benign prostatic hyperplasia: Helps improve urine flow in men with an enlarged prostate.
• Long-term prostate size management: Helps reduce prostate size over time, lowering the risk of acute urinary retention and the need for BPH-related surgery.
• Night-time urinary frequency: Eases the need to urinate frequently during the night caused by prostate enlargement.
Side effects of Alfuzosin + Dutasteride
Impotence (erectile dysfunction)
Decreased libido
Ejaculation disorders (decreased volume of ejaculate)
Breast enlargement or tenderness
Dizziness
How Alfuzosin + Dutasteride works
Alfuzosin + Dutasteride works through two separate actions that together relieve urinary symptoms caused by an enlarged prostate.
Alfuzosin is an alpha-blocker. It works by relaxing the smooth muscle in the prostate and bladder neck, which makes it easier for urine to flow and relieves symptoms such as a weak stream and difficulty starting urination.
Dutasteride is a 5-alpha reductase inhibitor. It works by blocking an enzyme that converts testosterone into a more potent hormone called dihydrotestosterone (DHT), which is responsible for prostate growth. By reducing DHT levels, Dutasteride helps shrink the prostate over time.
Together, Alfuzosin provides faster relief from urinary symptoms while Dutasteride addresses the underlying prostate enlargement, offering both immediate and long-term benefits.
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Written By
Doctor of Medicine
Reviewed By
BAMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
- Alfuzosin + Dutasteride is available in the form of oral tablets.
Age and Dose Restrictions
- Alfuzosin + Dutasteride is used by adult men and is not meant for use in women or children.
Contraindications
- This medicine should not be used in patients who have a known allergy to either alfuzosin, dutasteride, or any other components of this medication.
Other Medications to Avoid With This Medicine
- Alfuzosin + Dutasteride may interact with potent inhibitors of cytochrome P4503A4 (such as ketoconazole, itraconazole, and ritonavir), other alpha-blockers (like prazosin and tamsulosin), and erectile dysfunction medications (such as sildenafil and tadalafil).
Overdose and Missed Dose
- Taking more than the prescribed dose of Alfuzosin + Dutasteride may cause symptoms such as dizziness, low blood pressure, or fainting. If you suspect an overdose, seek medical attention immediately.
- If you miss a dose of Alfuzosin + Dutasteride, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve after stopping this medicine. However, if you experience any severe side effects or worsening symptoms, please consult your doctor.
- To manage dry mouth, stay well hydrated, chew sugar-free gum, or suck on sugar-free hard candies.
- If the medication causes insomnia, avoid taking it close to bedtime.
Use in Driving and Operating Machinery
- Alfuzosin + Dutasteride can cause dizziness, especially when starting the medication. Therefore, caution should be taken when driving or operating machinery until you know how this medicine affects you.
Use in Pregnancy and Lactation
- Alfuzosin + Dutasteride is not recommended for use in women. It can pose significant risks to a developing foetus when used during pregnancy and is therefore contraindicated.
Caution in Other Conditions
- People with a history of liver disease should be cautious while using this medication due to the potential for increased side effects.
- Caution is also advised for individuals known to have orthostatic hypotension (a sudden fall in blood pressure when standing).
Special Dietary and Lifestyle Recommendation
- Regular physical activity can help increase urinary flow and relieve some symptoms of BPH.
- Limiting beverages in the evening can help reduce the need for frequent urination during the night.
- Avoiding or limiting caffeine and alcohol may help reduce symptoms, as they can increase urine production and irritate the bladder.
Frequently asked questions
Is Alfuzosin + Dutasteride a steroid?
No, it is not a steroid. It consists of two active ingredients - Alfuzosin, which is an alpha-blocker, and Dutasteride, which is a 5-alpha reductase inhibitor.
Does Alfuzosin + Dutasteride have any effect on sleep?
This medicine usually does not affect sleep. However, if you experience sleep disturbances after starting this medication, consult your doctor promptly.
Will Alfuzosin + Dutasteride affect fertility?
One of the common side effects of this medication is decreased libido. However, there is no direct evidence of an impact on long-term fertility. If you have any concerns about this matter, it would be best to consult your doctor.
Are there any particular diet restrictions while taking Alfuzosin + Dutasteride?
There are no specific dietary restrictions that need to be followed while taking this medicine.
Is it safe to take Alfuzosin + Dutasteride daily?
Yes, it is usually safe to take the medicine daily as per your doctor's prescribed dosage.
How much time does Alfuzosin + Dutasteride take to work?
The time taken for this medicine to show its effect may vary depending on individual body responses. Your doctor would be the best person to provide this information based on your specific situation.
Is Alfuzosin + Dutasteride available over the counter, or do I need a prescription?
This medicine requires a doctor's prescription and is not typically available over the counter.
Alfuzosin + Dutasteride in other salts
List of medicines for Alfuzosin + Dutasteride
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