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Acebrophylline + Doxofylline

Uses of Acebrophylline + Doxofylline

  • Acebrophylline + Doxofylline is primarily used for the symptomatic management of chronic obstructive pulmonary disease (COPD) and bronchial asthma and belongs to the group of bronchodilators.

  • It is also indicated for prophylaxis and symptomatic treatment of bronchospasm as well as adjunct therapy for respiratory conditions with bronchospasm like chronic bronchitis.

Side effects of Acebrophylline + Doxofylline

  • Nausea and vomiting

  • Abdominal discomfort

  • Headache

  • Palpitations

  • Skin rash

How Acebrophylline + Doxofylline works

  • Acebrophylline + Doxofylline is a bronchodilating combination.

  • Acebrophylline is an airway mucoregulator and an anti-inflammatory. It works by decreasing the thickness and stickiness of lung secretions, making them easier to cough up. It also has anti-inflammatory and antioxidant properties that help reduce inflammation in the airways.

  • Doxofylline is a type of chemical called a xanthine derivative, which has muscle-relaxing effects on the bronchial tubes in the lungs. By blocking certain enzymes (phosphodiesterases), it raises the levels of another chemical called cyclic AMP inside cells, resulting in relaxation and widening of airways. This leads to improved airflow in the lungs. It is less likely to cause side effects because it has minimal activity on receptors for another chemical called adenosine.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Acebrophylline + Doxofylline can be taken orally (tablets and syrups).

Age and Dose Restrictions

  • This medicine is suitable for adults and children aged 12 years and above.

Contraindications

  • Acebrophylline + Doxofylline is contraindicated in patients with known hypersensitivity to acebrophylline or doxofylline, as well as other xanthine derivatives.

  • It should not be used by patients who have suffered an acute myocardial infarction, have an arrhythmia, or hemodynamic instability.

Other Medications to Avoid

  • This combination may interact with antibiotics (such as ciprofloxacin, erythromycin, and clarithromycin), corticosteroids (like prednisone), diuretics (including furosemide), beta-2 agonists (such as salbutamol), and monoamine oxidase inhibitors (like selegiline).

  • Before starting any new medications, consult a doctor to manage the risk of potential interactions.

Overdose and Missed Dose

  • An overdose of Acebrophylline + Doxofylline might lead to severe symptoms such as seizures, arrhythmias, or severe vomiting. Immediate medical attention should be sought in case of overdose.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If experiencing nausea, try taking the medicine with or after food.

  • For headaches, ensure you are well-hydrated by drinking sufficient water throughout the day.

  • If palpitations occur, rest and avoid caffeine-containing products.

Use in Driving and Operating Machinery

  • Acebrophylline + Doxofylline may cause dizziness or blurred vision. It is advised to avoid driving or operating heavy machinery until you know how this medication affects you.

Use in Pregnancy and Lactation

  • The safety of Acebrophylline + Doxofylline during pregnancy and lactation has not been established. It should be used only if clearly needed and prescribed by a doctor.

  • Consult your doctor before using this medicine if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Caution is advised when using Acebrophylline + Doxofylline in patients with peptic ulcer disease, seizure disorders, cardiovascular diseases such as hypertension, hyperthyroidism, or conditions affecting liver or kidney function.

  • Patients with these conditions should discuss their health status with their doctor to ensure safe use of this medication.

Special Dietary and Lifestyle Recommendations

  • Avoid caffeine-containing foods and beverages as they can increase the side effects of Acebrophylline + Doxofylline.

  • Smoking cessation is crucial, as smoking can decrease the efficacy of the medication.

  • Engage in gentle physical activities like walking or stretching which can help improve lung function over time.

  • Maintain a healthy diet rich in fruits and vegetables to support overall health and potentially reduce inflammation.

  • Practice breathing exercises regularly to help improve lung capacity and ease respiratory symptoms.

Frequently asked questions

Yes, one of the side effects associated with Acebrophylline + Doxofylline includes dizziness and blurred vision. Therefore, it is advised to avoid tasks requiring mental alertness, such as driving or operating machinery, until you understand how the medicine affects you.

Yes, in rare cases, Acebrophylline + Doxofylline can cause severe allergic reactions. If you experience symptoms such as rash, itching, difficulty breathing, or swelling of the face, lips, or throat, seek immediate medical attention.

It is recommended to avoid caffeine-containing foods and beverages while on this medication as it can increase the risk of side effects.

Apart from COPD and asthma, this combination is also used as an adjunct therapy for respiratory conditions with bronchospasm like chronic bronchitis.

Yes, smoking may decrease the efficacy of this medication by increasing its clearance.

This medication is contraindicated in neonates, infants and children under 12 years of age.

For natural alternatives to this medication, please consult your doctor as they would best advise you based on your specific condition and medical history.

Terms & Conditions


Available medicines for ACEBROPHYLLINE + DOXOFYLLINE
Spirodin Ab Tablet 10
Spirodin Ab Tablet 10
Koye Pharmaceuticals Pvt. Ltd.
Pack of 10 Units
₹121.36
MRP ₹148.00
18.00% OFF
Acebrofon Dx Tablet 10
Acebrofon Dx Tablet 10
Knoll Healthcare Pvt. Ltd.
Pack of 10 Units
₹131.20
MRP ₹160.00
18.00% OFF
S Phyllin Dx Tablet 10
S Phyllin Dx Tablet 10
Steris Healthcare
Pack of 10 Units
₹73.85
MRP ₹148.00
50.10% OFF

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