Methoxsalen

Dosage Forms Available

• Methoxsalen is available for administration via oral (tablets and capsules) and topical (lotion, ointment) routes.

Age and Dose Restrictions

• Methoxsalen is indicated for use in adults and children over the age of 12 years.

Contraindications

• Methoxsalen should not be used in patients with known sensitivities or allergies to psoralen compounds. This medication is contraindicated in individuals with conditions like lupus erythematosus (inflammatory connective tissue disorder that occurs when the body's immune system attacks its own tissues), xeroderma pigmentosum (genetic disorder in which the ability to repair damaged DNA is decreased), and other diseases that increase sensitivity to UV light.

Other Medications to Avoid

• Methoxsalen may interact with anticoagulants (e.g., warfarin, jantoven), staining dyes (e.g., methylene blue, toluidine blue), coal tar (e.g., Neutrogena T/Gel, psoriasin) and certain antibiotics (e.g., tetracyclines, sulfonamides).

Overdose and Missed Dose

• Taking too much Methoxsalen - particularly before UVA exposure - significantly increases the risk of severe skin burns, painful blistering, and peeling. If you have taken more than the prescribed dose, avoid all sunlight and UVA light exposure immediately and seek urgent medical advice. Do not proceed with any scheduled PUVA session.
• If you miss a dose of Methoxsalen before a scheduled PUVA session, inform your treating doctor or specialist before proceeding. Do not take a double dose. Your doctor will advise whether the session should be rescheduled to ensure safe and effective treatment.

Management of Side Effects

Most side effects of Methoxsalen are temporary and resolve upon discontinuation of the medication. However, consult your doctor if symptoms persist or worsen.

• To reduce itching and dryness, apply a moisturiser frequently.

Use in Driving and Operating Machinery

• Methoxsalen can cause dizziness and blurred vision. Avoid driving or operating heavy machinery if you experience any of these side effects.

Use in Pregnancy and Lactation

• Consult your doctor before using Methoxsalen if you are pregnant or breastfeeding, as its safety in these conditions is not fully established.

Caution in Other Conditions

• Methoxsalen should be used with caution in patients with liver or kidney dysfunction, as it may affect the metabolism and excretion of the medicine. Patients with a history of skin cancer should use this medicine with caution due to the increased risk of skin damage from UV light.

Special Dietary and Lifestyle Recommendations

• Limit your exposure to sunlight since Methoxsalen increases sensitivity to UV light. Wear protective clothing and use sunscreen when outdoors.
• Keep your skin hydrated and moisturised to prevent dryness and peeling.