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Azelnidipine + Olmesartan Medoxomil

Uses of Azelnidipine + Olmesartan Medoxomil

Azelnidipine + Olmesartan Medoxomil is used to manage high blood pressure (hypertension), combining a calcium channel blocker with an angiotensin receptor blocker.
This combination is commonly used for:
• Hypertension: Lowers persistently high blood pressure through two complementary mechanisms.
• Long-term blood pressure control: Provides sustained management of blood pressure in patients who need more than one antihypertensive agent.
• Reducing cardiovascular risk: Helps lower the risk of complications associated with uncontrolled high blood pressure, such as stroke and heart disease, when used as prescribed.

Side effects of Azelnidipine + Olmesartan Medoxomil

  • Dizziness

  • Headache

  • Fatigue

  • Nausea

  • Ankle swelling

How Azelnidipine + Olmesartan Medoxomil works

Azelnidipine + Olmesartan Medoxomil works through two separate mechanisms to lower blood pressure.
Azelnidipine is a calcium channel blocker. It blocks calcium from entering the cells of blood vessel walls, causing the vessels to relax and widen. This reduces resistance to blood flow and lowers blood pressure.
Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB). It blocks the action of angiotensin II, a hormone that normally narrows blood vessels. By preventing this effect, olmesartan allows blood vessels to widen further, reducing blood pressure.
Together, both medicines provide more effective blood pressure control than either medicine used alone.

Certified content

Written By

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Dr Nikita LoboMedical Content Reviewer| 9 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi RoshaMedical Content Writer| 10 years

BAMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Azelnidipine + Olmesartan Medoxomil is available in tablet form for oral administration.

Age and Dose Restrictions

  • This medicine is meant for use in adults only.

Contraindications

  • Azelnidipine + Olmesartan Medoxomil is contraindicated in patients with severe kidney impairment or kidney failure.

  • The medicine should not be used by individuals with biliary obstruction.

  • It is also contraindicated for those with hypersensitivity to either azelnidipine, olmesartan, or any other component of the formulation.

Other Medications to Avoid

  • This combination may interact with diuretics (eg., furosemide and hydrochlorothiazide), potassium supplements or salt substitutes containing potassium (eg., potassium chloride), NSAIDs (eg., ibuprofen and naproxen), and medicines that increase lithium levels (eg., lithium carbonate).

Overdose and Missed Dose

  • Taking more than the prescribed dose may cause extreme dizziness, a rapid heartbeat, or severe gastrointestinal distress. If you suspect an overdose, seek medical attention immediately.

  • If you miss a dose of Azelnidipine + Olmesartan Medoxomil, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not take an extra dose to make up for a missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • If experiencing dizziness, try taking the medication at bedtime to help minimise the impact during waking hours.

  • For mild nausea or gastrointestinal upset, consider taking the medication with food, unless otherwise directed by your doctor.

  • To manage ankle swelling, elevate your feet when possible and reduce salt intake.

Use in Driving and Operating Machinery

  • This medicine may impair your ability to drive or operate heavy machinery. Avoid these activities if you experience dizziness or drowsiness after taking Azelnidipine + Olmesartan Medoxomil.

Use in Pregnancy and Lactation

  • This medicine is not recommended during pregnancy and breastfeeding unless recommended by a healthcare professional. Consult your doctor before taking this medicine during pregnancy and breastfeeding.

Caution in Other Conditions

  • Individuals with existing kidney diseases should exercise caution while taking this medicine. Regular monitoring of kidney function may be necessary.

  • Patients who experience dehydration should be cautious when using this medication due to increased risks related to blood pressure drops.

Special Dietary and Lifestyle Recommendations

To effectively manage hypertension, which Azelnidipine + Olmesartan Medoxomil helps control, consider adopting certain lifestyle and dietary changes:

  • Consume a diet low in salt and rich in fruits, vegetables, whole grains, and low-fat dairy products.

  • Engage regularly in moderate physical activities such as brisk walking, cycling, or swimming for at least 150 minutes per week.

  • Monitor your weight and aim for a healthy body weight to help lower blood pressure.

  • Reduce intake of high-cholesterol foods and avoid trans fats which can contribute to artery clogging.

  • Limit alcohol consumption as it can raise blood pressure.

  • Manage stress through relaxation techniques such as yoga, meditation, or deep breathing exercises.

Frequently asked questions

No, Azelnidipine + Olmesartan Medoxomil is not a steroid. It is a combination medication consisting of two active ingredients: Azelnidipine, which is a long-acting dihydropyridine calcium channel blocker, and Olmesartan medoxomil, which is an angiotensin II receptor blocker (ARB).

There is no direct evidence to suggest that Azelnidipine + Olmesartan Medoxomil causes sleep problems. However, if you experience any unusual symptoms after taking this medication, such as persistent insomnia or excessive sleepiness, it is recommended to consult your doctor.

There is currently no scientific data suggesting that Azelnidipine + Olmesartan Medoxomil adversely affects fertility in men or women. However, if you are planning to conceive or have encountered fertility issues, it would be best to discuss this with your doctor.

Generally, there are no specific dietary restrictions when taking Azelnidipine + Olmesartan Medoxomil. However, a healthy diet low in sodium and rich in fruits and vegetables can help manage hypertension.

Yes, Azelnidipine + Olmesartan Medoxomil is designed to be taken daily for managing hypertension. It should be consumed as directed by your doctor.

The blood pressure-lowering effect of Azelnidipine + Olmesartan Medoxomil is generally noticeable within 2 weeks of treatment commencement, with full effect usually achieved by 4 weeks.

Azelnidipine + Olmesartan Medoxomil can be taken at any time of the day, with or without food. However, it is often recommended to take it at the same time each day to help remember your dosage.

Terms & Conditions


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