Ursodeoxycholic Acid
HepatoprotectiveUses of Ursodeoxycholic Acid
Ursodeoxycholic Acid (UDCA) is a bile acid used to treat selected liver and gallbladder conditions caused by abnormal bile flow or composition.
It is commonly used for:
• Primary biliary cholangitis (PBC): Slows disease progression by improving bile flow and reducing bile-acid-related liver injury.
• Gallstone dissolution: Helps dissolve small, non-calcified cholesterol gallstones in selected patients who have a functioning gallbladder and are not suitable for surgery.
• Intrahepatic cholestasis of pregnancy: May relieve itching and lower bile acid levels under specialist obstetric supervision.
• Other cholestatic liver disorders: May be considered by a liver specialist in selected cases, but benefits vary and it is not an established treatment for every cholestatic condition.
Side effects of Ursodeoxycholic Acid
- Diarrhoea
How Ursodeoxycholic Acid works
- UDCA works by replacing harmful bile acids with a milder, less toxic one, reducing damage to liver cells.
- In certain liver conditions, toxic bile acids build up and damage liver cells. UDCA changes the overall make-up of bile, making it less damaging.
- It also increases the flow of bile from the liver into the intestine, helping clear toxic substances more efficiently.
- In gallstone disease, UDCA reduces the amount of cholesterol released into bile, making it less likely to form crystals. Over time, this can dissolve small existing gallstones and help prevent new ones from forming.
Certified content
Written By
MBBS
Reviewed By
MBBS, DNB (OBGY)
Expert Advice
Dosage Forms Available
- Tablet
Age and Dose Restrictions
- It is intended for adults and children above 6 years.
Contraindications
- It is contraindicated in patients with a history of hypersensitivity to Ursodeoxycholic Acid and patients with biliary obstructtion and liver impairment.
Other Medications To Avoid With This Medicine
- Avoid taking cholesterol lowering medications (colestyramine), immunosupressants (cyclosporin), antibiotics (ciprofloxacin), and oral contraceptives (ehinylestradiol). These medications may alter the safety and effectiveness of Ursodeoxycholic Acid.
Overdose and Missed Dose
- Ursodeoxycholic Acid is generally well tolerated, but taking more than the prescribed dose may cause diarrhoea. Serious side effects from overdose are uncommon. If you accidentally take a larger dose than prescribed and experience persistent or severe symptoms, consult your doctor promptly.
- If you miss a dose of Ursodeoxycholic Acid, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to compensate. As UDCA is often prescribed for long-term conditions, consistent daily use is important for best results.
Use In Driving And Operating Machinery
- It does not affect the ability to drive or operate machinery.
Use in Pregnancy and Lactation
- It is not recommended in pregnancy and breastfeeding.
Caution In Other Conditions
- Caution is advised in older adults and in liver diseases.
Special Dietary & Lifestyle Recommendation
- Include bell peppers, citrus fruits, leafy vegetables, and tomatoes in your daily meals. These are rich in essential nutrients.
- Integrate milk, fish, and low-fat dairy products into your diet to ensure an adequate calcium intake.
- Opt for plant-based protein sources like beans, nuts, lentils, tofu, and tempeh to contribute to gallbladder health.
- Consume foods rich in vitamins B and C, which benefit the gallbladder.
- Steer clear of high-fat, trans-fat, and processed foods that can harm gallbladder health.
- Eliminate white bread, white pasta, and sugars from your diet to support overall health.
- Minimize or avoid tobacco and alcohol consumption, as these habits can impact gallbladder function negatively.
Frequently asked questions
Does Ursodeoxycholic Acid cure fatty liver?
It is primarily prescribed for conditions like primary biliary cirrhosis and gallstone dissolution. Its effectiveness in treating fatty liver may vary, and it's crucial to consult a doctor for guidance on managing it.
Is Ursodeoxycholic Acid safe?
It is generally considered safe when used as a doctor prescribes. However, individual responses to medications may vary. It's important to discuss any concerns and side effects with your doctor.
How long can I take Ursodeoxycholic Acid?
The duration of use depends on the specific medical condition for which it is prescribed. Your doctor will determine the appropriate duration based on your case. Follow your doctor's instructions regarding the duration of treatment.
Is Ursodeoxycholic Acid good for constipation?
It is not typically used for treating constipation. If you are experiencing constipation, discussing this symptom with your doctor for appropriate management is advisable.
Can Ursodeoxycholic Acid dissolve gallstones?
Yes, it is often prescribed to dissolve certain types of gallstones, particularly cholesterol gallstones.
Ursodeoxycholic Acid in other salts
List of medicines for Ursodeoxycholic Acid
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