Tegaserod is a gut-motility medicine used to treat irritable bowel syndrome with constipation (IBS-C) in selected women younger than 65 years who have a low risk of cardiovascular disease.
Tegaserod is commonly used for:
• Irritable bowel syndrome with constipation (IBS-C): Relieves constipation, bloating, and abdominal discomfort associated with this condition.
• Chronic idiopathic constipation: Manages long-term constipation of unknown cause in women below 55 years of age.
Tegaserod is prescribed with caution and is generally avoided in people with a history of heart disease or stroke.
Diarrhoea
Headache
Abdominal pain
Nausea
Flatulence
Dizziness
Tegaserod acts on serotonin receptors, specifically the 5-HT4 receptors, found in the gastrointestinal tract.
By stimulating these receptors, Tegaserod enhances the natural muscle movements of the bowel, helping stool pass through the intestines more easily. This improves bowel motility and relieves symptoms such as constipation and bloating.
Tegaserod also reduces the sensitivity of nerves in the gut that transmit pain signals, which helps ease the abdominal pain and discomfort often experienced with IBS-C.

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Tegaserod can be taken orally (tablets).
This medicine is predominantly meant for adult women under the age of 65 years.
This medicine is contraindicated in patients with a history of ischemic colitis, stroke, heart attack, or transient ischemic attacks.
It is also contraindicated in patients with moderate or severe renal impairment or end-stage renal disease.
Additionally, it should not be used by those with moderate or severe liver impairment.
Tegaserod may interact with CYP3A4 inhibitors (such as ketoconazole and clarithromycin), CYP3A4 inducers (like rifampin and carbamazepine), certain cardiac medications (like digoxin) and oral contraceptives.
If you miss a dose of Tegaserod, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the one you missed.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
In case of diarrhoea, ensure to stay hydrated by drinking plenty of water.
If you experience a headache or dizziness, rest and avoid sudden movements.
Tegaserod may cause dizziness. Therefore, it is advised to avoid driving or operating heavy machinery until you know how this medicine affects you.
It is not known whether Tegaserod is safe for use during pregnancy or breastfeeding. Therefore, it is advisable to consult your doctor before taking this medicine if you are pregnant or breastfeeding.
Patients with a history of cardiovascular issues or bowel obstruction, kidney or liver disease should exercise caution when using Tegaserod.
Incorporating a diet high in fibre can help manage the symptoms of irritable bowel syndrome.
Regular light exercises like walking or yoga may be beneficial.
It's also advisable to maintain a regular eating schedule and avoid skipping meals to help regulate bowel function.
Frequently asked questions
No, Tegaserod is not a steroid. It falls under the class of medications known as selective serotonin type 4 receptor agonists.
There is no mention of Tegaserod causing sleep disturbances in the provided references. However, if you experience any adverse effects such as sleep problems while taking this medicine, consult your doctor.
If you are planning to conceive or are concerned about fertility, discuss this with your doctor.
Tegaserod requires a prescription from a doctor and is not available over the counter.
Tegaserod should be taken as prescribed by your doctor. The dosage will depend on your personal medical condition.
Tegaserod may start to show its effect within a few days of treatment, but the full effect can take up to 4-6 weeks.
The ideal time to take Tegaserod will be recommended by your doctor. It is usually taken 30 minutes before meals.
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