Gliclazide

Dosage Forms Available

• Gliclazide is available as an oral tablet, usually in immediate-release and modified-release forms. 

Age and Dose Restrictions

• Gliclazide is not recommended for children below 18 years.

Contraindications

• This medication is contraindicated in individuals with type 1 diabetes, severe kidney or liver disease, diabetic ketoacidosis (DKA), or allergy to sulfonylureas. It should also be avoided by individuals who experience frequent episodes of hypoglycemia.

Other Medications to Avoid

• Avoid taking gliclazide with certain antibiotics (ciprofloxacin, clarithromycin), antifungals (fluconazole), beta-blockers (propranolol, atenolol), diuretics (furosemide), corticosteroids (prednisolone), and certain antidepressants (fluoxetine, sertraline), as they may increase or decrease blood sugar levels unpredictably. Always inform your doctor about any medications you are using.

Overdose and Missed Dose

• An overdose of gliclazide can lead to severe hypoglycemia, which may cause confusion, excessive sweating, blurred vision, or fainting. In case of an overdose, consume a source of quick-acting sugar such as fruit juice, sugar cubes, or candy and seek immediate medical help.
• If you miss a dose, take it as soon as you remember. If it is close to the next scheduled dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed one.

Management of Side Effects

• To manage hypoglycemia, consume a fast-acting sugar source such as fruit juice, glucose tablets, or a sugary snack. If symptoms persist or worsen, seek medical help immediately. If nausea or dizziness occurs, try taking the medication with food. Patients experiencing weight gain should follow a balanced diet and engage in regular physical activity.

Use in Driving and Operating Machinery

• Gliclazide may cause dizziness or drowsiness, particularly if blood sugar levels drop too low. It is advised to avoid driving or operating heavy machinery until you are sure how the medication affects you.

Use in Pregnancy and Lactation

• Gliclazide is not recommended during pregnancy or breastfeeding due to potential risks to the baby. Alternative diabetes management options should be discussed with a doctor.

Caution in Other Conditions

• This medication should be used with caution in individuals with kidney or liver disease, adrenal or pituitary disorders, heart problems, or those prone to frequent hypoglycemia. Patients should monitor their blood sugar levels regularly to prevent complications.

Special Dietary and Lifestyle Recommendations

• Consume a balanced diet with low-glycemic index foods, such as green vegetables, whole grains, and lean proteins.
• Limit sugary and processed foods to prevent blood sugar spikes.
• Engage in regular exercise, such as walking or yoga, to improve insulin sensitivity.