Enclomiphene
Uses of Enclomiphene
The main use of Enclomiphene is in the management of infertility in women who are not ovulating properly or have polycystic ovary syndrome (PCOS). It belongs to the group of non-steroidal selective oestrogen receptor modulators (SERMs).
Enclomiphene is also used to manage secondary hypogonadism in men, a condition where the body does not produce enough testosterone.
Side effects of Enclomiphene
Hot flashes
Headache
Nausea and vomiting
Breast tenderness
Visual disturbances
How Enclomiphene works
- Enclomiphene works by influencing the hormonal signalling pathway that controls reproduction and testosterone production in the body.
- It attaches to oestrogen receptors in the hypothalamus, a region of the brain that regulates hormone release. By blocking these receptors, the hypothalamus is prompted to release Gonadotropin-Releasing Hormone (GnRH). This signal travels to the pituitary gland, which then releases two important hormones Follicle Stimulating Hormone (FSH) and Luteinising Hormone (LH).
- In women, FSH and LH work together to stimulate the ovaries to mature and release an egg, supporting natural ovulation.
- In men, LH signals the testes to produce testosterone, helping restore healthy hormone levels without directly suppressing the body's own production unlike external testosterone therapy.
Certified content
Written By
MSc (Applied Genetics)
Reviewed By
BAMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Enclomiphene can be taken orally (tablet, capsule, powder, and solution).
Age and Dose Restrictions
Enclomiphene is commonly prescribed to adults.
Contraindications
Enclomiphene is contraindicated in patients with known hypersensitivity to Enclomiphene or any of its components. It is also contraindicated in patients with undiagnosed abnormal uterine bleeding, ovarian cysts or enlargement not due to PCOS, liver dysfunction or disease, and hormone-dependent tumours like breast, uterine, or ovarian cancer.
Other Medications to Avoid
Enclomiphene may interact with oestrogens, oral contraceptives (such as ethinyl estradiol), lipid-lowering medicines (like statins), thyroid hormone replacement medication (such as levothyroxine), and immunosuppressants (such as cyclosporine).
Overdose and Missed Dose
- An overdose of Enclomiphene may cause symptoms such as nausea, vomiting, hot flushes, visual disturbances, or signs of ovarian hyperstimulation syndrome (OHSS) in women, which may include bloating and pelvic discomfort. If any of these symptoms are observed after taking more than the prescribed dose, contact your doctor or visit the nearest hospital immediately.
If you miss a dose of Enclomiphene, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses together to make up for a missed one.
Management of Side Effects
Most side effects of Enclomiphene are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage side effects, patients should avoid spicy foods to reduce nausea and abdominal discomfort.
If hot flashes occur, wear light clothing and stay in a cool environment.
Use in Driving and Operating Machinery
Enclomiphene can cause visual disturbances like blurred vision or spots. This may affect your ability to drive or operate heavy machinery. It is advisable to avoid these activities if you experience any such side effects.
Use in Pregnancy and Lactation
Enclomiphene is not recommended for use during pregnancy or breastfeeding unless advised by the doctor. If you are pregnant or breastfeeding, consult your doctor before starting this medicine.
Caution in Other Conditions
Caution is advised when using Enclomiphene in patients with liver disease, abnormal uterine bleeding, or ovarian cysts. It's important that these patients are closely monitored for any complications during treatment.
Special Dietary and Lifestyle Recommendations
Ensure adequate rest and manage stress through relaxation techniques like meditation or yoga.
Frequently asked questions
Is Enclomiphene a steroid?
No, Enclomiphene is not a steroid. It is a non-steroidal selective oestrogen receptor modulator (SERM) used in the management of infertility and hypogonadism.
Does Enclomiphene have any effect on mood?
There is no known impact of Enclomiphene on mood. However, hormonal changes induced by the medicine might indirectly influence mood in some individuals.
Will Enclomiphene affect fertility?
Yes, Enclomiphene is primarily used to manage infertility in both men and women by stimulating hormone production, which leads to the release of eggs from the ovaries in women and testosterone production in men.
Is it safe to take Enclomiphene daily?
It is recommended to take Enclomiphene as prescribed by your doctor. The medication is generally taken for 5 days starting from the 5th day of the menstrual cycle.
How much time does Enclomiphene take to work?
Ovulation typically occurs 5-12 days after the last dose of Enclomiphene. Most women will ovulate within the first three cycles of treatment.
What is the best time to take Enclomiphene?
The best time to take Enclomiphene should be decided as per your doctor’s recommendation. It can be taken with or without food.
Can one become dependent on Enclomiphene?
There is no known risk of dependency or addiction with Enclomiphene. However, it should always be taken under the supervision of a doctor, and one should not exceed the prescribed dosage or duration of treatment.
List of medicines for Enclomiphene
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