Artesunate + Mefloquine

Dosage Forms Available

• Artesunate + Mefloquine is available via the oral route (tablet), intravenous or intramuscular route (injection).

Age and Dose Restrictions

• This combination medicine is meant for both adults and children. However, for children, dose adjustments are necessary based on body weight.

Contraindications

• Artesunate + Mefloquine is contraindicated in patients with known hypersensitivity to either Artesunate or Mefloquine.

• It is also contraindicated in patients with a history of psychiatric disorders or seizures associated with Mefloquine use.

• Lastly, it is not recommended for patients with severe hepatic impairment.

Other Medications to Avoid

• Artesunate + Mefloquine may interact with strong CYP3A4 inducers (such as rifampin and phenytoin), and strong CYP3A4 inhibitors (like ketoconazole and ritonavir), and medications that prolong the QTc interval (like quinolones, macrolides, and tricyclic antidepressants).

Overdose and Missed Dose

• Taking more than the prescribed dose may cause severe effects such as seizures or heart-related complications. If you suspect an overdose, seek medical attention immediately.

• If you miss a dose of Artesunate + Mefloquine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• Drinking plenty of fluids can help manage some gastrointestinal side effects like diarrhoea and abdominal pain.

• Rest and relaxation techniques can help manage the side effects of the nervous system, such as headaches and dizziness.

Use in Driving and Operating Machinery

• Artesunate + Mefloquine may cause dizziness or fatigue in some individuals. If affected, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• Artesunate + Mefloquine should only be used during pregnancy if clearly needed and the benefits outweigh potential risks. It is advised that breastfeeding mothers should avoid this medication. Always consult your doctor before using this medicine during pregnancy or lactation.

Caution in Other Conditions

• Individuals with cardiac conduction abnormalities or arrhythmias should exercise caution when taking Artesunate + Mefloquine.

• This medicine should also be used cautiously by individuals with electrolyte disturbances (like hypokalaemia, and hypomagnesaemia) and renal impairment.

Special Dietary and Lifestyle Recommendations

• Drink plenty of fluids to stay hydrated, which can help with the management of diarrhoea.

• Avoid alcohol consumption, as it may enhance the sedative effect of this medicine.

• Get adequate rest to help manage fatigue or sleep disturbances.