Riociguat

Dosage Forms Available

• Riociguat is available in film-coated tablet form for oral administration.

Age and Dose Restrictions

• Riociguat is meant for adults.

Contraindications

• This medicine is contraindicated in patients with idiopathic interstitial pneumonia. It is also contraindicated in patients who are hypersensitive to Riociguat.

Other Medications to Avoid

• This medicine can interact with certain antifungals (e.g., itraconazole, ketoconazole), HIV protease inhibitors (e.g., ritonavir), medications for seizures (e.g., carbamazepine, phenobarbital, phenytoin), and medications for high blood pressure.

Overdose and Missed Dose

• Overdosing on Riociguat may induce symptoms like severe hypotension and fainting. If you suspect an overdose, it is important to seek immediate medical attention.

• If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

• For mild cases of dizziness or lightheadedness resulting from low blood pressure, try to stand up slowly when rising from a sitting or lying position.

• If you experience nausea or vomiting, try eating smaller frequent meals throughout the day instead of larger ones.

• Increase your water intake if you experience diarrhoea to prevent dehydration.

Use in Driving and Operating Machinery

• Riociguat may cause side effects like dizziness or lightheadedness which can affect your ability to drive or operate machinery. It is advised to avoid such tasks until you know how the medicine affects you.

Use in Pregnancy and Lactation

• This medicine is not recommended during pregnancy and breastfeeding unless recommended by a healthcare professional. It is advised to consult your doctor before using this medicine during these periods.

Caution in Other Conditions

• Patients with renal or hepatic impairment should exercise caution when taking Riociguat. Dose adjustments may be necessary based on the severity of the impairment.

• Patients with pulmonary veno-occlusive disease should also exercise caution, as Riociguat may worsen this condition.

Special Dietary and Lifestyle Recommendations

• Regular monitoring of blood pressure is advised for patients taking Riociguat.

• Limiting salt intake may help manage symptoms of pulmonary arterial hypertension.

• Regular walking and low-intensity aerobic exercises can help improve cardiovascular fitness and vascular health.