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Riluzole

Uses of Riluzole

Riluzole is a neuroprotective medicine used to slow disease progression and extend survival in patients with amyotrophic lateral sclerosis (ALS).

It is commonly used for:

  • Amyotrophic lateral sclerosis (ALS): Delays the progression of motor neuron degradation in ALS (a form of motor neuron disease), helping prolong overall survival and time until tracheostomy or mechanical ventilation is required.

Side effects of Riluzole

  • Fatigue and weakness

  • Nausea and vomiting

  • Decreased lung function

  • Abdominal pain

  • Dizziness

How Riluzole works

  • Riluzole belongs to a class of neurological medicines called benzothiazoles.
  • In patients with amyotrophic lateral sclerosis (ALS), excessive activity of glutamate—a chemical messenger in the central nervous system—causes toxicity and damage to motor nerve cells. Riluzole works by blocking voltage-gated sodium channels on nerve membranes, which inhibits the release of excess glutamate from nerve endings.
  • By decreasing glutamate release and promoting its reabsorption, Riluzole protects motor neurons from glutamate-induced excitotoxicity, thereby slowing the degeneration of nerve cells controlling muscle movement.

Certified content

Written By

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Dr Nikita LoboMedical Content Reviewer| 9 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi RoshaMedical Content Writer| 10 years

BAMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Riluzole is available in the form of tablets and can be taken orally.

  • This medicine also comes as an oral suspension, which is a liquid to be swallowed.

  • Additionally, Riluzole is available as an oral film that dissolves on the tongue.

Age and Dose Restrictions

  • Riluzole is generally meant for adults.

  • The safety and effectiveness of this medication in children have not been established.

Contraindications

  • Riluzole is contraindicated in patients who have had severe hypersensitivity reactions to Riluzole or any of its components in the past.

Other Medications to Avoid

  • Riluzole may interact with blood thinners (warfarin), respiratory medicines (such as theophylline), and antibiotics (quinolones), possibly leading to increased side effects.

  • Before starting any prescription or over-the-counter medications, it is crucial to consult a doctor, as using these medicines with Riluzole may not be recommended.

Overdose and Missed Dose

  • Symptoms of an overdose of Riluzole may include hypertension (high blood pressure), tachycardia (rapid heartbeat), nausea and vomiting, drowsiness, and confusion. If you experience these symptoms, seek immediate medical attention.

  • If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage side effects such as dry mouth.

  • Eating small, frequent meals instead of large ones can help manage nausea.

  • Standing up slowly from a sitting or lying position can help manage dizziness.

Use in Driving and Operating Machinery

  • Riluzole may cause side effects like dizziness. Thus, if you feel dizzy or sleepy after taking this medicine, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

  • The safety and effectiveness of Riluzole in pregnant women and breastfeeding mothers have not been established.

  • It is advised to consult your doctor before using this medicine during pregnancy and breastfeeding.

Caution in Other Conditions

  • Riluzole should be used with caution in patients with pre-existing liver disease, as it may worsen liver function.

  • Patients with neutropenia (low white blood cell count) or interstitial lung disease should also be closely monitored during treatment.

Special Dietary and Lifestyle Recommendations

  • Drink plenty of water throughout the day to stay hydrated.

  • Consume a balanced diet rich in fruits, vegetables, lean protein, and whole grains to support overall health.

  • Regularly visit your doctor for check-ups and follow the prescribed medication regimen strictly.

  • Smoking can decrease the effectiveness of Riluzole. Try to quit or cut down on smoking.

Frequently asked questions

No, Riluzole is not a painkiller. It is a medication used for managing amyotrophic lateral sclerosis (ALS) and belongs to the benzothiazole class of medicines.

Yes, Riluzole can be taken on an empty stomach.

It is not advisable to smoke while taking Riluzole. Cigarette smoking may decrease Riluzole levels in the body, which could potentially reduce the effectiveness of the medicine.

Weight gain is not listed as a common side effect of Riluzole. However, individual responses to medication may vary, and if you experience unexpected weight changes, it is advised to consult your doctor.

Yes, for patients who have difficulty swallowing, Riluzole is available as an oral suspension or oral film that dissolves on the tongue.

If you forget to take your dose of Riluzole, take it as soon as you remember, unless it is nearly time for your next dose. Do not double up doses to make up for a missed one. Always consult your doctor if you are unsure.

It is generally not recommended to stop taking any medication, including Riluzole, without consulting your doctor. Abruptly stopping Riluzole may cause unwanted effects or worsen your condition. Always discuss with your doctor before making any changes to your medication regimen.

Terms & Conditions

List of medicines for Riluzole

Rilutor 50 Mg Tablet 10
Rilutor 50 Mg Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹150
MRP ₹187.5
20% OFF

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