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Ranolazine

Antianginal

Uses of Ranolazine

  • Ranolazine is prescribed for the management of a specific type of persistent chest pain known as stable angina.

Side effects of Ranolazine

  • Dizziness
  • Headache
  • Feeling sick
  • Constipation

How Ranolazine works

  • Ranolazine works by reducing the influx of sodium ions into the heart muscle cells. This process interferes with the function of specialised channels on the cell surface, known as sodium-dependent calcium channels, which are responsible for allowing calcium ions to enter the cells under normal conditions. By limiting the entry of calcium ions, Ranolazine helps decrease heart muscle cell contraction. Since calcium ions are crucial in triggering muscle contractions, reducing their flow enables the heart to relax more efficiently. This improved relaxation enhances blood flow to the heart muscle, alleviating the symptoms of angina pectoris and contributing to better heart function.

Certified content

Written By

docImg
Amit SharmaClinical Health & Medical Writer| 4 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Ranolazine is available in the form of tablets or granules to be taken orally.

Age and Dose Restrictions

  • This medicine is meant for adults.

Contraindications

  • The medication is not recommended in patients with a known allergy to Ranolazine and preexisting liver and kidney issues.

Other Medications to Avoid

  • Ranolazine is known to have contraindications when used alongside certain medications prescribed for various conditions. These include antibiotics used to treat bacterial infections, such as clarithromycin and telithromycin; lipid-lowering drugs like simvastatin and atorvastatin; and antifungal medications, including itraconazole, ketoconazole, voriconazole, and posaconazole. Additionally, it may interact with protease inhibitors used in the treatment of HIV infection. Ranolazine is also contraindicated with certain antipsychotic medications, such as haloperidol and nefazodone, along with medications used for heart rhythm disorders, including quinidine, dofetilide, and sotalol.

Overdose and Missed Dose

  • An overdose of this medication may cause symptoms like dizziness, nausea, and vomiting. If you observe these symptoms, inform your doctor and follow the advice accordingly.
  • If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

Use in Driving and Operating Machinery

  • This medication will not impair your ability to drive and operate heavy machinery. 

Use in Pregnancy and Lactation

  • Ranolazine is not recommended for use in pregnancy and breastfeeding unless recommended by your doctor.

Caution in Other Conditions

  • Patients with long QT intervals or who are using other QT-prolonging medicines.
  • Avoid alcohol when taking Ranolazine.

Special Dietary and Lifestyle Recommendations

  • Maintain a healthy lifestyle by engaging in regular physical exercise, keeping your body weight within a healthy range, and following a well-balanced, nutritious diet to support overall well-being.
  • If you have a history of kidney disease or liver disease, it is essential to inform your doctor before starting Ranolazine, as these conditions may affect how the medication is processed in your body.
  • Avoid consuming alcohol while taking Ranolazine, as it can lead to excessive drowsiness and may also increase the risk of muscle pain, which can further impact your overall health.
  • As a precautionary measure, refrain from consuming junk food or processed meals from outside sources. Instead, prioritize freshly prepared, home-cooked meals to aid in a speedy recovery and promote better treatment outcomes.

Frequently asked questions

Ranolazine does not provide immediate relief from chest pain but helps reduce the frequency of angina episodes over time. It may take a few hours to days to show effects, with maximum benefits appearing after a few weeks of regular use.

Avoid alcohol, grapefruit juice, and certain medications that may interact with Ranolazine. Inform your doctor if you have a history of kidney, liver, or heart rhythm disorders. Do not exceed the prescribed dose, as it may increase the risk of side effects.

No, do not stop taking Ranolazine without consulting your doctor. Abrupt discontinuation may worsen angina symptoms or increase the risk of complications. Always follow your doctor’s instructions regarding dosage adjustments.

Ranolazine should be used with caution in patients with kidney or liver disease, as impaired organ function may lead to increased drug accumulation, raising the risk of side effects. Severe liver disease patients should avoid Ranolazine entirely.

There is no significant evidence suggesting that Ranolazine affects fertility in men or women. However, if you are planning to conceive, consult your doctor for personalised advice.

Terms & Conditions

List of Medicines for Ranolazine

Ranozed 500 Tablet 10
Ranozed 500 Tablet 10
Jagsonpal Pharmaceuticals Ltd
Pack of 10 Units
₹114.72
MRP ₹229.9
50.1% OFF
Ranogard Tablet 10
Ranogard Tablet 10
Abbott Healthcare Pvt. Ltd
Pack of 10 Units
₹84.89
MRP ₹106.11
20% OFF
Rancv 500 Tablet 10
Rancv 500 Tablet 10
Msn Laboratories Ltd
Pack of 10 Units
₹102.64
MRP ₹128.3
20% OFF
Rancad Tablet 15
Rancad Tablet 15
Lupin Ltd
Pack of 15 Units
₹276.68
MRP ₹345.85
20% OFF
Ranozex Tablet 10
Ranozex Tablet 10
Sun Pharma Laboratories Ltd.
Pack of 10 Units
₹159.2
MRP ₹199
20% OFF
Rolazin Tablet 10
Rolazin Tablet 10
Macleods Pharmaceuticals Pvt.ltd
Pack of 10 Units
₹134.23
MRP ₹165
18.65% OFF
Ranolaz Tablet 15
Ranolaz Tablet 15
Torrent Pharmaceuticals Ltd.
Pack of 15 Units
₹252.8
MRP ₹316
20% OFF
Ranx 500 Tablet 15
Ranx 500 Tablet 15
Torrent Pharmaceuticals Ltd.
Pack of 15 Units
₹274.8
MRP ₹343.5
20% OFF

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