Pefloxacin is a broad-spectrum fluoroquinolone antibiotic used to treat a range of bacterial infections.
Pefloxacin is commonly used for:
• Respiratory tract infections: Treats bacterial infections of the lungs and airways.
• Urinary tract infections: Manages infections of the bladder, urethra, and kidneys caused by bacteria.
• Skin and soft tissue infections: Treats bacterial infections affecting the skin and underlying tissue.
• Bone and joint infections: Manages bacterial infections affecting the bones and joints.
• Gastrointestinal infections: Treats certain bacterial infections of the digestive tract.
Nausea and vomiting
Diarrhoea
Headache and dizziness
Skin rash and itching
Pefloxacin belongs to the fluoroquinolone class of antibiotics.
It works by blocking two enzymes that bacteria need, called DNA gyrase and topoisomerase IV. These enzymes are essential for bacteria to replicate, repair, and organise their DNA.
By interfering with these processes, Pefloxacin prevents bacteria from multiplying and spreading, which leads to their death and helps control the infection.

Doctor of Medicine

BAMS, FMC, MD Resident
Pefloxacin is available via oral route (tablets). It can also be administered intravenously (injection).
Pefloxacin is meant for adults above 18 years of age.
This medicine is contraindicated in patients with known allergies to Pefloxacin or other quinolones. It is also contraindicated in patients taking tizanidine.
Pefloxacin may interact with antacids (such as aluminium hydroxide, sucralfate, ferrous sulfate, and zinc sulfate), anticoagulants (such as warfarin), and NSAIDs (like ibuprofen and naproxen).
If you miss a dose of Pefloxacin, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose. Completing the full prescribed course is important to prevent the infection from returning or becoming resistant to antibiotics.
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If you experience nausea or vomiting, taking your medicine with food might help.
If you become dizzy or lightheaded, sit or lie down until the symptoms pass.
Pefloxacin may make you feel dizzy or lightheaded. Avoid driving or operating heavy machinery if you experience these symptoms.
Pefloxacin is not recommended during pregnancy and breastfeeding unless your doctor advises it. Always consult your doctor before using this medicine if you are pregnant or breastfeeding.
Patients with kidney disease should use Pefloxacin cautiously, as dosage adjustments may be required.
Individuals with a history of seizures should also exercise caution while taking this medicine due to the risk of seizure exacerbation.
To avoid photosensitivity reactions, limit exposure to sunlight and UV light, such as tanning beds. Wear protective clothing and use sunscreen with a high SPF when outdoors.
Regular hand washing and avoiding close contact with people with infections can help prevent catching or spreading infections.
Frequently asked questions
While it is not common, some people taking Pefloxacin have reported experiencing mood changes or disturbances such as agitation, anxiety, depression, and even hallucinations. If you notice any changes in your mood or if you start to feel anxious or depressed while taking this medicine, consult your doctor immediately.
There are no natural alternatives that can replace the antibacterial action of Pefloxacin in managing bacterial infections. If you prefer a more holistic approach to healthcare, discuss this with your doctor who can guide you accordingly while ensuring you receive effective treatment for your infection.
Pefloxacin can be taken at any time of the day but should ideally be taken at the same time each day to maintain a constant level in the body. Always follow your doctor's instructions regarding the timing and frequency of doses.
No, Pefloxacin is not a steroid. Pefloxacin is a broad-spectrum fluoroquinolone antibiotic.
Yes, Pefloxacin can make your skin more sensitive to sunlight leading to sunburn more easily. You should avoid excessive exposure to sunlight or UV light and use sunscreen while taking this medicine.
Yes, Pefloxacin is generally safe for daily use as per your doctor's prescription. It is important to follow the prescribed dosage and duration meticulously.
Generally, Pefloxacin does not directly affect sleep patterns. However, side effects such as insomnia or dizziness may impact your sleep. If you experience these symptoms persistently, it is recommended to consult your doctor for advice.
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