Nevirapine

Dosage Forms Available

• Nevirapine is available for oral administration in the form of tablets and an oral suspension (liquid).

Age and Dose Restrictions

• This medicine is meant for adults, and children 15 days of age and older.

Contraindications

• Nevirapine is contraindicated in patients with moderate to severe liver impairment (Child-Pugh Class B or C).
• It should not be used by patients who have experienced severe rash or hepatic events with prior Nevirapine treatment.

Other Medications to Avoid

• Nevirapine can interact with protease inhibitors (like lopinavir and ritonavir), antifungals (such as ketoconazole), opioids (like methadone), and medication for tuberculosis (like rifampin).

Overdose and Missed Dose

• An overdose of Nevirapine may cause symptoms such as severe skin rash, fever, nausea, or stomach pain. If these symptoms are observed, contact a doctor immediately.
• If you forget to take a dose of Nevirapine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed one.

Management of Side Effects

Most side effects of Nevirapine are temporary and generally harmless, and resolve when discontinuing this medicine. However:

• Drinking plenty of fluids can help manage side effects like nausea and diarrhoea.
• Resting and avoiding strenuous activities can help handle fatigue.
• Taking this medication with meals can minimise stomach discomfort.

Use in Driving and Operating Machinery

• Nevirapine may cause dizziness or tiredness. If these symptoms are experienced, avoid driving or operating heavy machinery.

Use in Pregnancy and Lactation

• The use of Nevirapine should be avoided during pregnancy and breastfeeding unless deemed necessary and recommended by a healthcare professional.

Caution in Other Conditions

• Caution is advised when using Nevirapine in patients with hepatitis B or C coinfection, as well as in those with mild liver impairment (Child-Pugh Class A).

Special Dietary and Lifestyle Recommendations

To improve overall health and well-being while managing HIV:

• Practise safe sex to prevent transmission of the virus.
• Regularly wash hands to prevent infections.
• Regular medical check-ups are crucial for monitoring the progress of the disease.