Monosulfiram
Uses of Monosulfiram
- Monosulfiram is primarily used to treat parasitic skin infections like scabies and belongs to the antiscabietic and anthelmintic group of medicines.
- In addition to treating scabies, Monosulfiram's antibacterial and antifungal properties help manage secondary bacterial and fungal infections that may arise from scabies. It is available in solutions or soaps and may also be combined with benzyl benzoate.
Side effects of Monosulfiram
- Mild burning sensation
- Itching
- Skin redness
- Dryness
- Skin irritation
How Monosulfiram works
- Monosulfiram is an antiscabietic and anthelmintic.
- It acts by disrupting the nervous system of parasites, particularly the scabies mite (Sarcoptes scabiei). It achieves this by interfering with an enzyme named acetylcholinesterase in the parasites, which eventually leads to their paralysis and death. This ingredient also has antibacterial and antifungal properties that aid in managing secondary bacterial and fungal infections that may occur due to scabies.
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Written By
BAMS, FMC, MD Resident
Reviewed By
Doctor of Medicine
Expert Advice
Dosage Forms Available
- Monosulfiram is available as a topical formulation. The most commonly used product is a medicated soap. The soap is applied on the body and scalp to manage parasitic skin infections.
Age and Dose Restrictions
- Monosulfiram medicated soap is safe for use by both adults and children. It is not recommended for infants below 2 months of age unless advised by a doctor.
Contraindications
- Monosulfiram soap should not be used by individuals who have a known allergy to Monosulfiram or any of the other ingredients in the soap.
- It is also contraindicated in individuals with severe skin conditions or very sensitive skin.
Other Medications to Avoid
- No significant interactions have been reported between Monosulfiram and other medications. However, using other topical products at the same time as Monosulfiram may reduce its effectiveness and increase the risk of side effects.
Overdose and Missed Dose
- Overdose of Monosulfiram is unlikely as it is intended for external use only. Using the prescribed dosage is recommended to avoid any side effects.
- If a scheduled application of the soap is missed, it should be done as soon as remembered. Regular use helps ensure optimal results from the treatment.
Management of Side Effects
Most side effects associated with Monosulfiram are temporary and resolve once the therapy is discontinued. However, if you experience any severe side effects or worsening of symptoms, please consult your doctor.
- If you experience skin dryness, applying a moisturiser can help.
- In case of mild burning sensation or itching, try not to scratch as it could worsen the condition.
Use in Driving and Operating Machinery
- Monosulfiram does not have any known effects on an individual's ability to drive or operate machinery.
Use in Pregnancy and Lactation
- Monosulfiram should be used under medical supervision in pregnant and breastfeeding women.
Caution in Other Conditions
- Individuals with severe skin conditions or very sensitive skin should use Monosulfiram with caution. It is best to consult your doctor before starting use.
- It should not be used on inflamed or broken skin as it may worsen irritation.
Special Dietary and Lifestyle Recommendations
- Maintain good personal hygiene to prevent the spread of scabies.
- Wash all clothing, bedding, and towels used by the affected individual in hot water to kill the mites.
- Vacuum the entire home, including furniture and rugs, to remove any mites or eggs.
Frequently asked questions
Is Monosulfiram a steroid?
No, Monosulfiram is not a steroid. It is an antiscabietic and anthelmintic.
Does Monosulfiram have any effect on sleep?
Monosulfiram is not associated with affecting sleep. However, its use can provide relief from intense itching associated with scabies, which may indirectly improve sleep quality.
Will Monosulfiram affect fertility?
Monosulfiram is not directly associated with affecting fertility. If you have any concerns, it is best to consult your doctor.
Is it safe to use Monosulfiram daily?
Yes, it is safe to use Monosulfiram daily for the prevention of infection and general hygiene. For managing active scabies infection, it should be used as per the recommendation of your doctor.
How much time does Monosulfiram take to work?
The relief from itching and rash due to scabies may start within a few days of using Monosulfiram soap. However, the entire course of treatment should be completed as directed by the doctor to ensure complete eradication of mites causing the infection.
What is the best time to use Monosulfiram?
Monosulfiram soap can be used at any time of the day for prevention of infection and general hygiene. For managing active scabies infection, follow your doctor's advice regarding its timing and frequency.
What happens if I accidentally get Monosulfiram soap in my eyes?
If Monosulfiram soap comes into contact with eyes or other mucous membranes, rinse thoroughly with water immediately. If symptoms persist, seek medical assistance.
What is Monosulfiram?
Monosulfiram is a drug used topically in the treatment of scabies and works by producing effects similar to those of disulfiram, a medication used in alcohol aversion therapy. It inhibits the enzyme aldehyde dehydrogenase, causing discomfort when alcohol is consumed and helping to discourage alcohol consumption. Additionally, it helps in treating scabies by targeting the skin infestation.
What is Monosulfiram used for?
Monosulfiram is an antiparasitic medication used to treat scabies and lice infestations.
List of Medicines for Monosulfiram
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