Mifepristone
Uses of Mifepristone
Mifepristone is a hormone-receptor blocker whose use depends on its strength and formulation.
It is commonly used for:
- Medical termination of early intrauterine pregnancy: The 200 mg formulation is used with misoprostol through 70 days of gestation under medical supervision.
- Hyperglycaemia due to endogenous Cushing's syndrome: Specific higher-dose formulations are used in selected adults with type 2 diabetes or glucose intolerance when surgery has failed or is not suitable.
Side effects of Mifepristone
Uterine cramping
Heavy bleeding
Nausea
Vomiting
Diarrhoea.
How Mifepristone works
- Mifepristone blocks different hormone receptors depending on the clinical use.
- For medical termination of pregnancy, it blocks progesterone receptors, causing the uterine lining to break down and increasing the uterus's response to misoprostol.
- For hyperglycaemia caused by endogenous Cushing's syndrome, higher-dose mifepristone blocks glucocorticoid receptors and reduces the effects of excess cortisol on blood sugar.
- The exact formulation and regimen must be prescribed and monitored by a doctor.
Certified content
Written By
BDS, MDS
Reviewed By
BAMS, FMC, MD Resident
Expert Advice
Dosage Forms Available
Mifepristone can be taken orally (tablet).
Age and Dose Restrictions
This medicine is meant for use by adults and adolescents aged 16 years and above.
Contraindications
This medicine is contraindicated in patients with confirmed or suspected ectopic pregnancy. Patients with chronic adrenal failure should avoid this medication. Those suffering from inherited porphyria are advised not to use this medicine. An uncontrolled seizure disorder also makes this medication contraindicated. If a patient has an intrauterine device (IUD) in place, Mifepristone is contraindicated. Individuals undergoing concurrent anticoagulant therapy or those with haemorrhagic disorders should avoid this medicine.
Other Medications to Avoid
This medicine can interact with CYP3A4 inducers (such as rifampin, carbamazepine, phenytoin, and St. John's Wort), CYP3A4 inhibitors (like ketoconazole, erythromycin, and grapefruit juice) and corticosteroids (such as prednisone and hydrocortisone).
Overdose and Missed Dose
An overdose of this medication can possibly result in serious complications. If you suspect an overdose, seek immediate medical attention.
If you miss a dose of Mifepristone, take it as soon as you remember. However, if it is near the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Management of Side Effects
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Drinking plenty of water can help manage some of the gastrointestinal side effects like nausea and diarrhoea.
Resting and avoiding strenuous activity may help manage fatigue and dizziness.
Use in Driving and Operating Machinery
This medication can cause dizziness or fatigue, which can affect your ability to drive or operate heavy machinery.
Use in Pregnancy and Lactation
Mifepristone should not be taken during pregnancy and breastfeeding unless advised by a doctor.
Caution in Other Conditions
Patients with anaemia are advised to use this medication with caution.
Individuals suffering from cardiovascular disease or inflammatory bowel disease should also exercise caution while taking this medication.
Caution should be exercised in patients with hepatic or renal impairment, as well as those with asthma.
Special Dietary and Lifestyle Recommendations
Regular check-ups with your doctor are essential to monitor your health while using this medication.
Maintain good hydration to promote better health while on this medication.
Frequently asked questions
Is Mifepristone a steroid?
Yes, Mifepristone is a synthetic steroid medication. It functions as an anti-progestogen, which means it blocks the effects of the hormone progesterone.
Can Mifepristone affect menstruation?
Mifepristone can cause heavy menstrual bleeding and cramping as it causes the uterine lining to break down. This is an expected reaction when the medicine is used for medical abortion.
Is it safe to consume alcohol while taking Mifepristone?
It is always advisable to consult your doctor about consuming alcohol while taking Mifepristone.
Does Mifepristone have any effect on mood?
Some people may experience mood changes after taking Mifepristone, although this is not a common side effect. If you experience any significant mood changes, you should inform your doctor.
Can Mifepristone be used for contraception?
Mifepristone is not a regular contraceptive and should not be used to prevent pregnancy. However, it can be used as an emergency contraceptive within 120 hours of unprotected intercourse.
Are there any natural alternatives to Mifepristone?
There are no known natural alternatives that can perform the same medical functions as Mifepristone.
Can I take Mifepristone if I have allergies?
If you are allergic to Mifepristone or any other prostaglandins, you should not take this medicine. Always inform your doctor about any allergies before starting a new medication.
Is the baby still alive after taking Mifepristone?
Mifepristone is mainly used for medical abortion, working by blocking the hormone progesterone to end a pregnancy. While it is generally effective, there is a chance that the pregnancy may continue after taking it. If the pregnancy does persist, there is a risk that the developing baby could be born with birth defects.
What does Mifepristone do to the baby?
Mifepristone is used to terminate an early pregnancy. It works by lowering the levels of progesterone, a hormone essential for maintaining pregnancy, thereby preventing its continuation.
Mifepristone in other salts
List of medicines for Mifepristone
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